Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition.

Autor: Pilo CA; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA.; Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA 92037, USA., Baffi TR; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA., Kornev AP; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA., Kunkel MT; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA., Malfavon M; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA., Chen DH; Department of Neurology, University of Washington, Seattle, WA 98195, USA., Rossitto LA; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA.; Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA 92037, USA., Chen DX; Department of Neurology, University of Washington, Seattle, WA 98195, USA., Huang LC; Institute of Bioinformatics, University of Georgia, Athens, GA 30602, USA., Longman C; Queen Elizabeth University Hospital, Glasgow, Scotland G51 4TF, UK., Kannan N; Institute of Bioinformatics, University of Georgia, Athens, GA 30602, USA.; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA., Raskind WH; Department of Medicine/Medical Genetics, University of Washington, Seattle, WA 98195, USA.; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA.; Mental Illness Research, Education and Clinical Center, Department of Veterans Affairs, Seattle, WA 98108, USA., Gonzalez DJ; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA., Taylor SS; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA., Gorrie G; Queen Elizabeth University Hospital, Glasgow, Scotland G51 4TF, UK., Newton AC; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA.

Publikováno v: Science signaling [Sci Signal] 2022 Sep 27; Vol. 15 (753), pp. eabk1147. Date of Electronic Publication: 2022 Sep 27.

Genetic Variants at PRKCG Splice and UTR Sites Promote Cancer Susceptibility by Disrupting Epigenetic and miRNA Regulatory Network.

Autor: Abid, Fizzah¹, Khan, Khushbukhat¹, Ashraf, Naeem Mahmood¹, Badshah, Yasmin¹, Shabbir, Maria¹, Trembley, Janeen H.¹, Afsar, Tayyaba², Almajwal, Ali², Razak, Suhail²

Publikováno v: Journal of Cancer. 2024, Vol. 15 Issue 20, p6644-6657. 14p.

Receptor Protein Tyrosine Phosphatase α-Mediated Enhancement of Rheumatoid Synovial Fibroblast Signaling and Promotion of Arthritis in Mice.

Autor: Stanford SM; La Jolla Institute for Allergy and Immunology, La Jolla, California., Svensson MN; La Jolla Institute for Allergy and Immunology, La Jolla, California., Sacchetti C; La Jolla Institute for Allergy and Immunology, La Jolla, California., Pilo CA; La Jolla Institute for Allergy and Immunology, La Jolla, California., Wu DJ; La Jolla Institute for Allergy and Immunology, La Jolla, California., Kiosses WB; The Scripps Research Institute, La Jolla, California., Hellvard A; Broegelmann Research Laboratory and University of Bergen, Bergen, Norway., Bergum B; Broegelmann Research Laboratory and University of Bergen, Bergen, Norway., Muench GR; La Jolla Institute for Allergy and Immunology, La Jolla, California., Elly C; La Jolla Institute for Allergy and Immunology, La Jolla, California., Liu YC; La Jolla Institute for Allergy and Immunology, La Jolla, California., den Hertog J; Hubrecht Institute-Koninklijke Nederlands Akademie van Wetenschappen and University Medical Center Utrecht, Utrecht, The Netherlands, and Institute of Biology, Leiden, The Netherlands., Elson A; Weizmann Institute of Science, Rehovot, Israel., Sap J; Université Paris Diderot, Sorbonne Paris Cité, Paris, France., Mydel P; Broegelmann Research Laboratory and University of Bergen, Bergen, Norway., Boyle DL; University of California at San Diego School of Medicine, La Jolla., Corr M; University of California at San Diego School of Medicine, La Jolla., Firestein GS; University of California at San Diego School of Medicine, La Jolla., Bottini N; La Jolla Institute for Allergy and Immunology, La Jolla, California.

Publikováno v: Arthritis & rheumatology (Hoboken, N.J.) [Arthritis Rheumatol] 2016 Feb; Vol. 68 (2), pp. 359-69.

Does a rare mutation in PTPRA contribute to the development of Parkinson's disease in an Australian multi-incident family?

Autor: Hill, Melissa A.¹ (AUTHOR), Bentley, Steven R.¹ (AUTHOR), Walker, Tara L.² (AUTHOR), Mellick, George D.¹ (AUTHOR), Wood, Stephen A.¹ (AUTHOR), Sykes, Alex M.¹ (AUTHOR) a.sykes@griffith.edu.au

Publikováno v: PLoS ONE. 7/28/2022, Vol. 17 Issue 7, p1-17. 17p.

Signaling Pathways That Mediate Alveolar Macrophage Activation by Surfactant Protein A and IL-4.

Autor: García-Fojeda, Belén, Minutti, Carlos M., Montero-Fernández, Carlos, Stamme, Cordula, Casals, Cristina

Publikováno v: Frontiers in Immunology; 4/4/2022, Vol. 13, p1-16, 16p