Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Pille Säälik"'
Publikováno v:
Bioconjugate chemistry. 29(4)
Proficient transport vectors called cell-penetrating peptides (CPPs) internalize into eukaryotic cells mostly via endocytic pathways and facilitate the uptake of various cargo molecules attached to them. However, some CPPs are able to induce disturba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ebf8ec2e2cbd45e344c024ff08412c6
https://pubmed.ncbi.nlm.nih.gov/29510042
https://pubmed.ncbi.nlm.nih.gov/29510042
Autor:
Pablo Scodeller, Sergei Kopanchuk, Michele De Palma, Lorena Simón-Gracia, Mario Leonardo Squadrito, Venkata Ramana Kotamraju, Kalle Kilk, Pille Säälik, Tambet Teesalu, Kaarel Kurm, Ago Rinken, Allan Tobi, Erkki Ruoslahti
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports
Scientific Reports
Tumor-associated macrophages (TAMs) expressing the multi-ligand endocytic receptor mannose receptor (CD206/MRC1) contribute to tumor immunosuppression, angiogenesis, metastasis, and relapse. Here, we describe a peptide that selectively targets MRC1-e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12e17c4923b1a8f574d58d9dc2312d7d
https://doi.org/10.1038/s41598-017-14709-x
https://doi.org/10.1038/s41598-017-14709-x
Autor:
Aira Niinep, Pille Säälik, Margus Pooga, Ülo Langel, Janely Pae, Mats Hansen, Dmitri Lubenets
Publikováno v:
Journal of Controlled Release. 153:117-125
The cellular internalization of cell-penetrating peptides (CPPs) is proposed to take place by both endocytic processes and by a direct translocation across the plasma membrane. So far only scarce data is available about what determines the choice bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3069f6a6cc1dfd2982ccf2e9056f36a0
https://doi.org/10.1016/j.jconrel.2011.03.011
https://doi.org/10.1016/j.jconrel.2011.03.011
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1798:2240-2248
The growing number of reports on the effective cargo delivery by cell-penetrating peptides (CPPs) has extensively widened our knowledge about the mechanisms involved in CPP-mediated delivery. However, the data available on the internalization mode of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6acf014c6b2c34135533529834f1946
https://doi.org/10.1016/j.bbamem.2010.02.013
https://doi.org/10.1016/j.bbamem.2010.02.013
Publikováno v:
Journal of Peptide Science. 16:71-80
A 12-mer peptide nucleic acid (PNA) directed against the nociceptin/orphanin FQ receptor mRNA was disulfide bridged with various peptides without and with cell-penetrating features. The cellular uptake and the antisense activity of these conjugates w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e7d4aa5bdef19155ff5a3a692c07c82
https://doi.org/10.1002/psc.1198
https://doi.org/10.1002/psc.1198
Publikováno v:
Bioconjugate Chemistry. 16:1399-1410
Attempts to unravel the cell translocation mechanism of a growing number of cell-penetrating peptides (CPP) have revealed molecular determinants essential for internalization ability. The peptide sequence and the charge have been proposed to be the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c601125c9749143de1ad37af85b63b40
https://doi.org/10.1021/bc050125z
https://doi.org/10.1021/bc050125z
Autor:
Laura Liivamägi, Pille Säälik, Piret Arukuusk, Ülo Langel, Janely Pae, Dmitri Lubenets, Margus Pooga
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 192
Despite the extensive research in the field of CPPs' cell entry the exact mechanisms underlying their cellular uptake and the role of involved cell surface molecules in the internalization process have remained controversial. The present study focuse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bc91d28802669494a570e5780f90d5c
https://pubmed.ncbi.nlm.nih.gov/25016968
https://pubmed.ncbi.nlm.nih.gov/25016968
Autor:
Margot Hein, Asko Kriiska, Margus Pooga, Ülo Langel, Pille Säälik, Anders Florén, Helin Räägel
Publikováno v:
Cellular and molecular life sciences : CMLS. 70(24)
Since their discovery, cell-penetrating peptides (CPPs) have provided a novel, efficient, and non-invasive mode of transport for various (bioactive) cargos into cells. Despite the ever-growing number of successful implications of the CPP-mediated del
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac40a3dd0344994d1bd174b852b0526
https://pubmed.ncbi.nlm.nih.gov/23852439
https://pubmed.ncbi.nlm.nih.gov/23852439
Autor:
Pille Säälik, Hedi Hunt, Allan Tobi, Anne-Mari Anton Willmore, Kadri Toome, Shweta Sharma, Ramana Kotamraju, Gabriele Bergers, Rolf Bjerkvig, Erkki Ruoslahti, Tambet Teesalu
Publikováno v:
Cancer Research. 76:1343-1343
Targeted delivery of cancer therapeutics using affinity ligands can dramatically improve antitumor efficacy. Over the years a number of homing peptides that upon systemic injection accumulate in solid tumors have been identified by in vivo peptide ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29b1e078861f1253ff50318b4ef3a3a6
https://doi.org/10.1158/1538-7445.am2016-1343
https://doi.org/10.1158/1538-7445.am2016-1343
Publikováno v:
Cancer Research. 76:2164-2164
Extracellular matrix protein tenascin C (TNC) is strongly overexpressed in the stroma of many solid tumors. TNC expression is upregulated at the invasive front of tumors while being nearly undetectable in normal adult tissues. TNC-targeted humanized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcc73178168c90354b98354e2e3c193c
https://doi.org/10.1158/1538-7445.am2016-2164
https://doi.org/10.1158/1538-7445.am2016-2164