Hemin-induced platelet activation is regulated by the ACKR3 chemokine surface receptor and has implications for passivation of vulnerable atherosclerotic plaques.

Autor: Laspa Z; Department of Cardiology and Angiology, University Hospital Tübingen, University Tübingen, Germany., Dicenta-Baunach V; Department of Cardiology and Angiology, University Hospital Tübingen, University Tübingen, Germany., Schaale D; Department of Cardiology and Angiology, University Hospital Tübingen, University Tübingen, Germany., Sigle M; Department of Cardiology and Angiology, University Hospital Tübingen, University Tübingen, Germany., Hochuli R; Department of Cardiology and Angiology, University Hospital Tübingen, University Tübingen, Germany., Castor T; Department of Cardiology and Angiology, University Hospital Tübingen, University Tübingen, Germany., Bayrak A; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, University Tübingen, Germany., Harm T; Department of Cardiology and Angiology, University Hospital Tübingen, University Tübingen, Germany., Müller KAL; Department of Cardiology and Angiology, University Hospital Tübingen, University Tübingen, Germany., Pillaiyar T; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, University Tübingen, Germany.; Tübingen Center for Academic Drug Discovery & Development (TüCAD2), Germany., Laufer S; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, University Tübingen, Germany.; Tübingen Center for Academic Drug Discovery & Development (TüCAD2), Germany.; iFIT Cluster of Excellence EXC 2180 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, Germany., Rohlfing AK; Department of Cardiology and Angiology, University Hospital Tübingen, University Tübingen, Germany., Gawaz MP; Department of Cardiology and Angiology, University Hospital Tübingen, University Tübingen, Germany.

Publikováno v: The FEBS journal [FEBS J] 2024 Oct 10. Date of Electronic Publication: 2024 Oct 10.

Nonpeptidic Irreversible Inhibitors of SARS-CoV-2 Main Protease with Potent Antiviral Activity.

Autor: Oneto A; Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn D-53121, Germany.; PharmaCenter Bonn, University of Bonn, Brühler Straße 7, Bonn D-53121, Germany., Hamwi GA; Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn D-53121, Germany.; PharmaCenter Bonn, University of Bonn, Brühler Straße 7, Bonn D-53121, Germany., Schäkel L; Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn D-53121, Germany.; PharmaCenter Bonn, University of Bonn, Brühler Straße 7, Bonn D-53121, Germany., Krüger N; Platform Infection Models, German Primate Center, Leibniz Institute for Primate Research Göttingen, Kellnerweg 4, Göttingen 37077, Germany., Sylvester K; Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn D-53121, Germany.; PharmaCenter Bonn, University of Bonn, Brühler Straße 7, Bonn D-53121, Germany., Petry M; Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn D-53121, Germany.; PharmaCenter Bonn, University of Bonn, Brühler Straße 7, Bonn D-53121, Germany., Shamleh RA; Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn D-53121, Germany.; PharmaCenter Bonn, University of Bonn, Brühler Straße 7, Bonn D-53121, Germany., Pillaiyar T; Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn D-53121, Germany.; PharmaCenter Bonn, University of Bonn, Brühler Straße 7, Bonn D-53121, Germany., Claff T; Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn D-53121, Germany.; PharmaCenter Bonn, University of Bonn, Brühler Straße 7, Bonn D-53121, Germany., Schiedel AC; Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn D-53121, Germany.; PharmaCenter Bonn, University of Bonn, Brühler Straße 7, Bonn D-53121, Germany., Sträter N; Center for Biotechnology and Biomedicine, Leipzig University, Deutscher Platz 5, Leipzig 04103, Germany., Gütschow M; Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn D-53121, Germany.; PharmaCenter Bonn, University of Bonn, Brühler Straße 7, Bonn D-53121, Germany., Müller CE; Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn D-53121, Germany.; PharmaCenter Bonn, University of Bonn, Brühler Straße 7, Bonn D-53121, Germany.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Sep 12; Vol. 67 (17), pp. 14986-15011. Date of Electronic Publication: 2024 Aug 15.

Correction to "Cathepsin-Targeting SARS-CoV-2 Inhibitors: Design, Synthesis, and Biological Activity".

Autor: Flury P; Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry and Tübingen Center for Academic Drug Discovery, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, Tübingen 72076, Germany., Breidenbach J; PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn 53121, Germany., Krüger N; Infection Biology Unit, German Primate Center, Leibniz Institute for Primate Research Göttingen, Kellnerweg 4, Göttingen 37077, Germany., Voget R; PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn 53121, Germany., Schäkel L; PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn 53121, Germany., Si Y; PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn 53121, Germany., Krasniqi V; PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn 53121, Germany., Calistri S; Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry and Tübingen Center for Academic Drug Discovery, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, Tübingen 72076, Germany., Olfert M; Institute of Pharmacy, Pharmaceutical (Bio-)Analysis, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany., Sylvester K; PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn 53121, Germany., Rocha C; Infection Biology Unit, German Primate Center, Leibniz Institute for Primate Research Göttingen, Kellnerweg 4, Göttingen 37077, Germany., Ditzinger R; Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry and Tübingen Center for Academic Drug Discovery, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, Tübingen 72076, Germany., Rasch A; Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry and Tübingen Center for Academic Drug Discovery, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, Tübingen 72076, Germany., Pöhlmann S; Infection Biology Unit, German Primate Center, Leibniz Institute for Primate Research Göttingen, Kellnerweg 4, Göttingen 37077, Germany.; Faculty of Biology and Psychology, University Göttingen, Göttingen 37073, Germany., Kronenberger T; Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry and Tübingen Center for Academic Drug Discovery, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, Tübingen 72076, Germany.; Faculty of Health Sciences, School of Pharmacy, University of Eastern Finland, Kuopio 70211, Finland.; Excellence Cluster 'Controlling Microbes to Fight Infections' (CMFI), Tübingen 72076, Germany., Poso A; Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry and Tübingen Center for Academic Drug Discovery, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, Tübingen 72076, Germany.; Faculty of Health Sciences, School of Pharmacy, University of Eastern Finland, Kuopio 70211, Finland., Rox K; Department of Chemical Biology, Helmholtz Centre for Infection Research (HZI), Braunschweig 38124, Germany.; Partner Site Hannover-Braunschweig, German Center for Infection Research (DZIF), Braunschweig 38124, Germany., Laufer SA; Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry and Tübingen Center for Academic Drug Discovery, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, Tübingen 72076, Germany., Müller CE; PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn 53121, Germany., Gütschow M; PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn 53121, Germany., Pillaiyar T; Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry and Tübingen Center for Academic Drug Discovery, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, Tübingen 72076, Germany.

Publikováno v: ACS pharmacology & translational science [ACS Pharmacol Transl Sci] 2024 Mar 06; Vol. 7 (4), pp. 1195-1196. Date of Electronic Publication: 2024 Mar 06 (Print Publication: 2024).

Development of Ligands for the Super Conserved Orphan G Protein-Coupled Receptor GPR27 with Improved Efficacy and Potency.

Autor: Pillaiyar T; Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry and Tübingen Center for Academic Drug Discovery, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany., Wozniak M; Laboratory of Molecular Pharmacology, GIGA-Molecular Biology of Diseases, University of Liège, B-4000 Liège, Belgium., Abboud D; Laboratory of Molecular Pharmacology, GIGA-Molecular Biology of Diseases, University of Liège, B-4000 Liège, Belgium., Rasch A; Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry and Tübingen Center for Academic Drug Discovery, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany., Liebing AD; Rudolf Schönheimer Institute of Biochemistry, Faculty of Medicine, Leipzig University, Johannisallee 30, 04103 Leipzig, Germany., Poso A; Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry and Tübingen Center for Academic Drug Discovery, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided & Functionally Instructed Tumor Therapies', University of Tübingen, 72076 Tübingen, Germany.; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio, Finland., Kronenberger T; Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry and Tübingen Center for Academic Drug Discovery, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided & Functionally Instructed Tumor Therapies', University of Tübingen, 72076 Tübingen, Germany.; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio, Finland., Stäubert C; Rudolf Schönheimer Institute of Biochemistry, Faculty of Medicine, Leipzig University, Johannisallee 30, 04103 Leipzig, Germany., Laufer SA; Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry and Tübingen Center for Academic Drug Discovery, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided & Functionally Instructed Tumor Therapies', University of Tübingen, 72076 Tübingen, Germany., Hanson J; Laboratory of Molecular Pharmacology, GIGA-Molecular Biology of Diseases, University of Liège, B-4000 Liège, Belgium.; Laboratory of Medicinal Chemistry, Centre for Interdisciplinary Research on Medicines (CIRM), University of Liège, B-4000 Liège, Belgium.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2023 Dec 28; Vol. 66 (24), pp. 17118-17137. Date of Electronic Publication: 2023 Dec 07.

Progress of Section "Biochemistry" in 2022.

Autor: Supuran, Claudiu T.¹ (AUTHOR) claudiu.supuran@unifi.it

Publikováno v: International Journal of Molecular Sciences. Mar2023, Vol. 24 Issue 6, p5873. 5p.