Výsledky vyhledávání - "Pilar Ximénez‐Embún"

Akademický článek

A rewiring of DNA replication mediated by MRE11 exonuclease underlies primed-to-naive cell de-differentiation

Autor: Patricia Ubieto-Capella, Pilar Ximénez-Embún, Daniel Giménez-Llorente, Ana Losada, Javier Muñoz, Juan Méndez

Publikováno v: Cell Reports, Vol 43, Iss 4, Pp 114024- (2024)

Summary: Mouse embryonic stem cells (mESCs) in the primed pluripotency state, which resembles the post-implantation epiblast, can be de-differentiated in culture to a naive state that resembles the pre-implantation inner cell mass. We report that pri

Externí odkaz: https://doaj.org/article/de8baade3db844c4bea1848d82e199f9

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Akademický článek

Decoding protein methylation function with thermal stability analysis

Autor: Cristina Sayago, Jana Sánchez-Wandelmer, Fernando García, Begoña Hurtado, Vanesa Lafarga, Patricia Prieto, Eduardo Zarzuela, Pilar Ximénez-Embún, Sagrario Ortega, Diego Megías, Oscar Fernández-Capetillo, Marcos Malumbres, Javier Munoz

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)

Abstract Protein methylation is an important modification beyond epigenetics. However, systems analyses of protein methylation lag behind compared to other modifications. Recently, thermal stability analyses have been developed which provide a proxy

Externí odkaz: https://doaj.org/article/7354965a01904389904458d4abac3798

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Akademický článek

Phosphoproteomic analysis of neoadjuvant breast cancer suggests that increased sensitivity to paclitaxel is driven by CDK4 and filamin A

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)

Phosphoproteomics is a promising tool for identifying biomarkers of treatment response in cancer. Here, the authors analyse proteomics profiling of HER2-negative female breast cancer patients and identify potential predictors of paclitaxel response.

Externí odkaz: https://doaj.org/article/41967f5bfad84ad8ad25940b81837779

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Akademický článek

pTINCR microprotein promotes epithelial differentiation and suppresses tumor growth through CDC42 SUMOylation and activation

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)

Small proteins encoded by previously assumed non-coding RNAs can have cell regulatory functions. Here the authors report that TINCR lncRNA encodes pTINCR, a ubiquitin-like protein (UBL) that promotes epithelial differentiation through the SUMOylation

Externí odkaz: https://doaj.org/article/33af4f773e164ef482636020595123dd

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Akademický článek

Ubiquitin proteomics identifies RNA polymerase I as a target of the Smc5/6 complex

Autor: Eva Ibars, Joan Codina-Fabra, Gemma Bellí, Celia Casas, Marc Tarrés, Roger Solé-Soler, Neus P. Lorite, Pilar Ximénez-Embún, Javier Muñoz, Neus Colomina, Jordi Torres-Rosell

Publikováno v: Cell Reports, Vol 42, Iss 5, Pp 112463- (2023)

Summary: Ubiquitination controls numerous cellular processes, and its deregulation is associated with many pathologies. The Nse1 subunit in the Smc5/6 complex contains a RING domain with ubiquitin E3 ligase activity and essential functions in genome

Externí odkaz: https://doaj.org/article/08586301399e43cfaf4387f9dbb06f3c

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Akademický článek

Characterization of plasma circulating small extracellular vesicles in patients with metastatic solid tumors and newly diagnosed brain metastasis

Autor: Alberto Carretero-González, Marta Hergueta-Redondo, Sara Sánchez-Redondo, Pilar Ximénez-Embún, Luis Manso Sánchez, Eva Ciruelos Gil, Daniel Castellano, Guillermo de Velasco, Héctor Peinado

Publikováno v: OncoImmunology, Vol 11, Iss 1 (2022)

Nearly 40% of the advanced cancer patients will present brain metastases during the course of their disease, with a 2-year life expectancy of less than 10%. Immune system impairment, including the modulation of both STAT3 and PD-L1, is one of the hal

Externí odkaz: https://doaj.org/article/abc9d2f726114963ae9a80538f61a02d

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Akademický článek

Dissection of two routes to naïve pluripotency using different kinase inhibitors

Autor: Ana Martinez-Val, Cian J. Lynch, Isabel Calvo, Pilar Ximénez-Embún, Fernando Garcia, Eduardo Zarzuela, Manuel Serrano, Javier Munoz

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

Naïve pluripotency can be stabilized through different pharmacological approaches. Here, the authors profile temporal changes of protein phosphorylation, proteome and metabolome as mESCs transition to the naïve state in response to two pharmacologi

Externí odkaz: https://doaj.org/article/6dc7983421e549f8afada656ff5c28a3

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Akademický článek

Topical heparin as an effective and safe treatment for patients with capecitabine-induced hand-foot syndrome: results of a phase IIA trial supported by proteomic profiling of skin biopsies

Autor: Analia Rodríguez-Garzotto, Lara Iglesias-Docampo, C. Vanesa Díaz-García, Isabel Ruppen, Pilar Ximénez-Embún, Carlos Gómez, J. Luis Rodríguez-Peralto, Javier Ortiz de Frutos, Jose A. Lopez-Martin, Cristina Grávalos, Hernán Cortés-Funes, M. Teresa Agulló-Ortuño

Publikováno v: Therapeutic Advances in Medical Oncology, Vol 14 (2022)

Background: Hand-foot syndrome (HFS) is a common adverse reaction associated with capecitabine chemotherapy that significantly affects the quality of life of patients. This study evaluates the safety and effectiveness of a topical heparin (TH) treatm

Externí odkaz: https://doaj.org/article/db84b09780b040ebac8582665d7c2c82

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Akademický článek

Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)

Hundreds of mRNA binding proteins (mRBPs) have been described in mammalian cells. Here, the authors identify RBPs differentially regulated in melanoma, and show the RBP CELF1 controlling a distinct set of protumorigenic factors.

Externí odkaz: https://doaj.org/article/1340379aab9748ac8e9ce5a84d0a223c

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Akademický článek

Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3

Autor: Michela Borghesan, Juan Fafián-Labora, Olga Eleftheriadou, Paula Carpintero-Fernández, Marta Paez-Ribes, Gema Vizcay-Barrena, Avital Swisa, Dror Kolodkin-Gal, Pilar Ximénez-Embún, Robert Lowe, Belen Martín-Martín, Hector Peinado, Javier Muñoz, Roland A. Fleck, Yuval Dor, Ittai Ben-Porath, Anna Vossenkamper, Daniel Muñoz-Espin, Ana O’Loghlen

Publikováno v: Cell Reports, Vol 27, Iss 13, Pp 3956-3971.e6 (2019)

Summary: Senescence is a cellular phenotype present in health and disease, characterized by a stable cell-cycle arrest and an inflammatory response called senescence-associated secretory phenotype (SASP). The SASP is important in influencing the beha

Externí odkaz: https://doaj.org/article/b729ed53c3154141a7268dbbac8c71b2

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