Zobrazeno 1 - 10
of 178
pro vyhledávání: '"Pilar Roca"'
Autor:
Pere Miquel Morla-Barcelo, David Laguna-Macarrilla, Octavi Cordoba, Gabriel Matheu, Jordi Oliver, Pilar Roca, Mercedes Nadal-Serrano, Jorge Sastre-Serra
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-15 (2024)
Abstract Background Early-stage invasive ductal carcinoma displays high survival rates due to early detection and treatments. However, there is still a chance of relapse of 3–15% after treatment. The aim of this study was to uncover the distinctive
Externí odkaz:
https://doaj.org/article/60c9e0c1232b4443a482394dcb7e24a0
Autor:
Toni Martinez-Bernabe, Pere Miquel Morla-Barcelo, Lucas Melguizo-Salom, Margalida Munar-Gelabert, Alba Maroto-Blasco, Margalida Torrens-Mas, Jordi Oliver, Pilar Roca, Mercedes Nadal-Serrano, Daniel Gabriel Pons, Jorge Sastre-Serra
Publikováno v:
Biology, Vol 13, Iss 9, p 724 (2024)
Chemoresistance remains a major challenge in the treatment of breast and colorectal cancer. For this reason, finding reliable predictive biomarkers of response to chemotherapy has become a significant research focus in recent years. However, validati
Externí odkaz:
https://doaj.org/article/d70077e47d5b469c8ae82f9453e01eec
Autor:
Emilia Amengual-Cladera, Pere Miquel Morla-Barcelo, Andrea Morán-Costoya, Jorge Sastre-Serra, Daniel Gabriel Pons, Adamo Valle, Pilar Roca, Mercedes Nadal-Serrano
Publikováno v:
Biology, Vol 13, Iss 5, p 302 (2024)
Metformin, a widely used anti-diabetic drug, has garnered attention for its potential in cancer management, particularly in breast and colorectal cancer. It is established that metformin reduces mitochondrial respiration, but its specific molecular t
Externí odkaz:
https://doaj.org/article/e392b798743a44399db4ec0c4ab687ed
Autor:
Margalida Torrens-Mas, Alejandro Collado-Solé, Alberto Sola-Leyva, María Paz Carrasco-Jiménez, Jordi Oliver, Daniel Gabriel Pons, Pilar Roca, Jorge Sastre-Serra
Publikováno v:
Biology, Vol 12, Iss 12, p 1457 (2023)
Alkylphospholipids (APLs) have been studied as anticancer drugs that interfere with biological membranes without targeting DNA. Although their mechanism of action is not fully elucidated yet, it is known that they disrupt the intracellular traffickin
Externí odkaz:
https://doaj.org/article/d5c3f8ffe9064f3ab364273f9a661dca
Publikováno v:
Redox Biology, Vol 31, Iss , Pp - (2020)
Compared to other organs, the brain is especially exposed to oxidative stress. In general, brains from young females tend to present lower oxidative damage in comparison to their male counterparts. This has been attributed to higher antioxidant defen
Externí odkaz:
https://doaj.org/article/146fa794b77d4e05847a3d79bc273ab4
Autor:
Reyniel Hernández-López, Margalida Torrens-Mas, Daniel G. Pons, Maria M. Company, Esther Falcó, Teresa Fernández, Javier M. Ibarra de la Rosa, Pilar Roca, Jordi Oliver, Jorge Sastre-Serra
Publikováno v:
Biology, Vol 11, Iss 2, p 293 (2022)
Most colorectal cancer (CRC) patients die as a consequence of metastasis. Mitochondrial dysfunction could enhance cancer development and metastatic progression. We aimed to evaluate the adaptations associated with mitochondrial function in tumor tiss
Externí odkaz:
https://doaj.org/article/acf11de8e2f944ad9d4ba20aa48eded8
Autor:
Toni Martinez-Bernabe, Jorge Sastre-Serra, Nicolae Ciobu, Jordi Oliver, Daniel Gabriel Pons, Pilar Roca
Publikováno v:
Antioxidants, Vol 10, Iss 9, p 1371 (2021)
Obesity, a physiological situation where different proinflammatory cytokines and hormones are secreted, is a major risk factor for breast cancer. Mitochondrial functionality exhibits a relevant role in the tumorigenic potential of a cancer cell. In t
Externí odkaz:
https://doaj.org/article/72a023086b954718bf4714478208f239
Autor:
Marco Cordani, Elisa Oppici, Ilaria Dando, Elena Butturini, Elisa Dalla Pozza, Mercedes Nadal-Serrano, Jordi Oliver, Pilar Roca, Sofia Mariotto, Barbara Cellini, Giovanni Blandino, Marta Palmieri, Silvia Di Agostino, Massimo Donadelli
Publikováno v:
Molecular Oncology, Vol 10, Iss 7, Pp 1008-1029 (2016)
Mutations in TP53 gene play a pivotal role in tumorigenesis and cancer development. Here, we report that gain‐of‐function mutant p53 proteins inhibit the autophagic pathway favoring antiapoptotic effects as well as proliferation of pancreas and b
Externí odkaz:
https://doaj.org/article/14a1910fbc7d421085e4c2c750ac4766
Autor:
Margalida Torrens-Mas, Pilar Roca
Publikováno v:
Biology, Vol 9, Iss 12, p 427 (2020)
Phytoestrogens are a large group of natural compounds found in more than 300 plants. They have a close structural similarity to estrogens, which allow them to bind to both estrogen receptors (ER), ERα and ERβ, presenting a weak estrogenic activity.
Externí odkaz:
https://doaj.org/article/4ed990afb41748ddb8c96bced9da6c6f
Publikováno v:
Cellular Physiology and Biochemistry, Vol 36, Iss 1, Pp 221-232 (2015)
Background/Aims: Large-scale epidemiological studies support a correlation between obesity and breast cancer in postmenopausal women. Circulating leptin levels are increased in obese and it has been suggested to play a significant role in mammary tum
Externí odkaz:
https://doaj.org/article/da7dca110b2f4115b977c96fa09a0ddb