Treg sensitivity to FasL and relative IL-2 deprivation drive idiopathic aplastic anemia immune dysfunction

Autor: Juan José Lozano, Linda Ariza-McNaughton, Jonathan M. Irish, Syed A Mian, Benedetta Costantini, Judith C. W. Marsh, Dominique Bonnet, Shahram Kordasti, Thanos P. Mourikis, Shok Ping Lim, Pilar Perez Abellan, Giovanni A M Povoleri, Ghulam J. Mufti, Susanne Heck, Giovanna Lombardi, Ander Abarrategi, Shreyans Gandhi, Marc Martinez Llordella, Rita Antunes Dos Reis

Publikováno v: Blood. 136:885-897

Idiopathic aplastic anemia (AA) has 2 key characteristics: an autoimmune response against hematopoietic stem/progenitor cells and regulatory T-cells (Tregs) deficiency. We have previously demonstrated reduction in a specific subpopulation of Treg in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c55ae0d92bc89d6a0015a27e7bff1ccb
https://doi.org/10.1182/blood.2019001347

Deep phenotyping of Tregs identifies an immune signature for idiopathic aplastic anemia and predicts response to treatment

Autor: N. Shaun B. Thomas, Shahram Kordasti, Farzin Farzaneh, Ghulam J. Mufti, Judith C. W. Marsh, Neal S. Young, Nedyalko Petrov, Alexander E. Smith, Kirsten E. Diggins, Jonathan M. Irish, Sun Sook Chung, Benedetta Costantini, Xingmin Feng, Pilar Perez Abellan, Richard Ellis, Cinzia Benfatto, Thomas Seidl, Marc Martinez Llordella, Rossella Melchiotti, Syed A Mian, Giovanni A M Povoleri, Emanuele de Rinaldis, Donal P. McLornan, Austin G. Kulasekararaj, Susanne Heck

Publikováno v: Kordasti, S, Costantini, B, Seidl, T, Perez Abellan, P, Martinez Llordella, M, Mclornan, D, Diggins, K E, Kulasekararaj, A, Benfatto, C, Feng, X, Smith, A, Mian, S A, Melchiotti, R, De Rinaldis, E D, Ellis, R, Petrov, N, Povoleri, G A M, Chung, S S, Thomas, N S B, Farzaneh, F, Irish, J M, Heck, S, Young, N S, Marsh, J C W & Mufti, G J 2016, ' Deep-phenotyping of Tregs identifies an immune signature for idiopathic aplastic anemia and predicts response to treatment ', Blood, vol. 128, no. 9, pp. 1193-1205 . https://doi.org/10.1182/blood-2016-03-703702

Idiopathic aplastic anemia (AA) is an immune-mediated and serious form of bone marrow failure. Akin to other autoimmune diseases, we have previously shown that in AA regulatory T-cells (Tregs) are reduced in number and function. The aim of this study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce76c670700366d15af9895335188199
https://pubmed.ncbi.nlm.nih.gov/27587862

Functional characterization of CD4+ T cells in aplastic anemia

Autor: Austin G. Kulasekararaj, Judith C. W. Marsh, Benedetta Costantini, Shahram Kordasti, Caroline Veen, Syed A Mian, Azim M Mohamedali, Ghulam J. Mufti, Thomas Seidl, Pilar Perez Abellan, Nana Benson-Quarm, Farzin Farzaneh, Jie Jiang, Alexander E. Smith, Sufyan Al-Khan

Publikováno v: Blood. 119:2033-2043

The role of CD4+ T cells in the pathogenesis of aplastic anemia (AA) is not well characterized. We investigate CD4+ T-cell subsets in AA. Sixty-three patients with acquired AA were studied. Th1 and Th2 cells were significantly higher in AA patients t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c1c8fff3c08c99c1bf9f3fae372b392
https://doi.org/10.1182/blood-2011-08-368308

The effects of 5-azacytidine on the function and number of regulatory T cells and T-effectors in myelodysplastic syndrome

Autor: Farzin Farzaneh, Azim M Mohamedali, Thomas Seidl, Benedetta Costantini, Pilar Perez Abellan, Austin G. Kulasekararaj, Nicolas Shaun B Thomas, Jie Jiang, Shahram Kordasti, Ghulam J. Mufti

Expansion of regulatory T cells occurs in high-risk myelodysplastic syndrome and correlates with a poor prognosis. DNA methyltransferase inhibitors, particularly 5-azacytidine, have been shown to increase the survival of patients with high-risk myelo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ccbf07a9c16aa2ee1f47d59c057cff3
https://europepmc.org/articles/PMC3729899/

Immunological Profile of Patients after HSCT Using the FCC Conditioning Regimen for Treatment of Severe Aplastic Anemia Shows Sustained Mixed T-Cell Chimerism Is Due to Persistence of Recipient CD8 T Cells and Indicates Potential Basis for Tolerance and Extremely Low Incidence of Graft Versus Host Disease

Autor: Muhammad Atif, Linda Barber, Austin G. Kulasekararaj, Judith C. W. Marsh, Nicholas Lea, Steven Best, Francesco Grimaldi, Ghulam J. Mufti, Rosemary Grain, Monica Sen, Victoria Potter, Pilar Perez-Abellan, Antonio Pagliuca, John P. Veluchamy

Publikováno v: Blood. 126:3129-3129

Mixed T-cell chimerism is frequent and persists despite discontinuation of immunosuppression after hematopoietic stem cell transplantation (HSCT) for severe aplastic anemia (SAA) using the fludarabine, cyclophosphamide and alemtuzumab/campath (FCC) c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::916d3c995905a884d18046ea1342d93c
https://doi.org/10.1182/blood.v126.23.3129.3129