Výsledky vyhledávání - "Pilar Negredo"

Akademický článek

Modulation of mechanosensory vibrissal responses in the trigeminocervical complex by stimulation of the greater occipital nerve in a rat model of trigeminal neuropathic pain

Autor: Nuria García-Magro, Pilar Negredo, Yasmina B. Martin, Ángel Nuñez, Carlos Avendaño

Publikováno v: The Journal of Headache and Pain, Vol 21, Iss 1, Pp 1-17 (2020)

Abstract Background Stimulation of the occipital or trigeminal nerves has been successfully used to treat chronic refractory neurovascular headaches such as migraine or cluster headache, and painful neuropathies. Convergence of trigeminal and occipit

Externí odkaz: https://doaj.org/article/4a23fb408a3847a89b0b8a0885fc4c9e

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Akademický článek

Implication of type 4 NADPH oxidase (NOX4) in tauopathy

Autor: Enrique Luengo, Paula Trigo-Alonso, Cristina Fernández-Mendívil, Ángel Nuñez, Marta del Campo, César Porrero, Nuria García-Magro, Pilar Negredo, Sergio Senar, Cristina Sánchez-Ramos, Juan A. Bernal, Alberto Rábano, Jeroen Hoozemans, Ana I. Casas, Harald H.H.W. Schmidt, Manuela G. López

Publikováno v: Redox Biology, Vol 49, Iss , Pp 102210- (2022)

Aggregates of the microtubule-associated protein tau are a common marker of neurodegenerative diseases collectively termed as tauopathies, such as Alzheimer's disease (AD) and frontotemporal dementia. Therapeutic strategies based on tau have failed i

Externí odkaz: https://doaj.org/article/b296e0e1f5164ab596b4e26bd355baf6

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Akademický článek

Protective role of microglial HO-1 blockade in aging: Implication of iron metabolism

Autor: Cristina Fernández-Mendívil, Enrique Luengo, Paula Trigo-Alonso, Nuria García-Magro, Pilar Negredo, Manuela G. López

Publikováno v: Redox Biology, Vol 38, Iss , Pp 101789- (2021)

Heme oxygenase-1 (HO-1) is an inducible enzyme known for its anti-inflammatory, antioxidant and neuroprotective effects. However, increased expression of HO-1 during aging and age-related neurodegenerative diseases have been associated to neurotoxic

Externí odkaz: https://doaj.org/article/dc6c307f580c455e9cc98ef7db32db44

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Akademický článek

Chronic administration of P2X7 receptor antagonist JNJ-47965567 delays disease onset and progression, and improves motor performance in ALS SOD1G93A female mice

Autor: Cristina Ruiz-Ruiz, Nuria García-Magro, Pilar Negredo, Carlos Avendaño, Anindya Bhattacharya, Marc Ceusters, Antonio G. García

Publikováno v: Disease Models & Mechanisms, Vol 13, Iss 10 (2020)

Neuroinflammation is one of the main physiopathological mechanisms of amyotrophic lateral sclerosis (ALS), produced by the chronic activation of microglia in the CNS. This process is triggered by the persistent activation of the ATP-gated P2X7 recept

Externí odkaz: https://doaj.org/article/366e327938e1491791efa02fb94b21d1

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Akademický článek

Multiple Morphometric Assessment of Microglial Cells in Deafferented Spinal Trigeminal Nucleus

Autor: Nuria García-Magro, Yasmina B. Martin, Alejandra Palomino-Antolin, Javier Egea, Pilar Negredo, Carlos Avendaño

Publikováno v: Frontiers in Neuroanatomy, Vol 13 (2020)

Microglia (MG) are the first cells to react to the abnormal incoming signals that follow an injury of sensory nerves and play a critical role in the development and maintenance of neuropathic pain, a common sequel of nerve injuries. Here we present p

Externí odkaz: https://doaj.org/article/454728db0ac4444eb09830d726669771

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Akademický článek

SENSORY INPUT-DEPENDENT CHANGES IN GLUTAMATERGIC NEUROTRANSMISSION- RELATED GENES AND PROTEINS IN THE ADULT RAT TRIGEMINAL GANGLION

Autor: Julia Fernandez-Montoya, Izaskun Buendia, Yasmina B Martin, Javier Egea, Pilar Negredo, Carlos Avendano

Publikováno v: Frontiers in Molecular Neuroscience, Vol 9 (2016)

Experience-dependent plasticity induces lasting changes in the structure of synapses, dendrites and axons at both molecular and anatomical levels. Whilst relatively well studied in the cortex, little is known about the molecular changes underlying ex

Externí odkaz: https://doaj.org/article/9956fee225754b2a87268044f05c9395

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Microglia and Inhibitory Circuitry in the Medullary Dorsal Horn: Laminar and Time-Dependent Changes in a Trigeminal Model of Neuropathic Pain

Autor: Nuria García-Magro, Pilar Negredo, Yasmina B. Martin, Carlos Avendaño, Francisco Zafra

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 4564, p 4564 (2021)
International Journal of Molecular Sciences
Digital.CSIC. Repositorio Institucional del CSIC
instname
DDFV: Repositorio Institucional de la Universidad Francisco de Vitoria
Universidad Francisco de Vitoria
Volume 22
Issue 9
DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
Biblos-e Archivo. Repositorio Institucional de la UAM

Craniofacial neuropathic pain affects millions of people worldwide and is often difficult to treat. Two key mechanisms underlying this condition are a loss of the negative control exerted by inhibitory interneurons and an early microglial reaction. B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d943f384bf7691e4e5fe849941efaa7
https://www.mdpi.com/1422-0067/22/9/4564

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Protective role of microglial HO-1 blockade in aging: Implication of iron metabolism

Autor: Nuria García-Magro, Cristina Fernández-Mendívil, Enrique Luengo, Paula Trigo-Alonso, Pilar Negredo, Manuela G. López

Publikováno v: Redox Biology, Vol 38, Iss, Pp 101789-(2021)
Redox Biology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43dfb34480f285e42eea2931b0cfeb92
http://www.sciencedirect.com/science/article/pii/S2213231720309940

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