Understanding LAG-3 Signaling

Autor: Luisa Chocarro, Ester Blanco, Miren Zuazo, Hugo Arasanz, Ana Bocanegra, Leticia Fernández-Rubio, Pilar Morente, Gonzalo Fernández-Hinojal, Miriam Echaide, Maider Garnica, Pablo Ramos, Ruth Vera, Grazyna Kochan, David Escors

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 10, p 5282 (2021)

Lymphocyte activation gene 3 (LAG-3) is a cell surface inhibitory receptor with multiple biological activities over T cell activation and effector functions. LAG-3 plays a regulatory role in immunity and emerged some time ago as an inhibitory immune

Externí odkaz: https://doaj.org/article/33914f6bb11346f589343e400f8dfe06

PD-L1 in Systemic Immunity: Unraveling Its Contribution to PD-1/PD-L1 Blockade Immunotherapy

Autor: Ana Bocanegra, Ester Blanco, Gonzalo Fernandez-Hinojal, Hugo Arasanz, Luisa Chocarro, Miren Zuazo, Pilar Morente, Ruth Vera, David Escors, Grazyna Kochan

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 16, p 5918 (2020)

The use of monoclonal antibodies targeting PD-1/PD-L1 axis completely changed anticancer treatment strategies. However, despite the significant improvement in overall survival and progression-free survival of patients undergoing these immunotherapy t

Externí odkaz: https://doaj.org/article/8e9849ef77144f90831919628a3540ad

Immune Profiling Uncovers Memory T-Cell Responses with a Th17 Signature in Cancer Patients with Previous SARS-CoV-2 Infection Followed by mRNA Vaccination

Autor: Miriam Echaide, Ibone Labiano, Marina Delgado, Angela Fernández de Lascoiti, Patricia Ochoa, Maider Garnica, Pablo Ramos, Luisa Chocarro, Leticia Fernández, Hugo Arasanz, Ana Bocanegra, Ester Blanco, Sergio Piñeiro-Hermida, Pilar Morente, Ruth Vera, Maria Alsina, David Escors, Grazyna Kochan

Publikováno v: Cancers; Volume 14; Issue 18; Pages: 4464

It is unclear whether patients with cancer present inherently impaired responses to COVID-19 and vaccination due to their treatments, neoplastic diseases or both. To address this question, immune profiling was performed in three cohorts of healthy do

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f1adb90b36d4d2d0df9a52cfc22380
https://doi.org/10.3390/cancers14184464

17P PD-1 and LAG-3 immune checkpoints constitutive activators exhibit differential expression phenotypes

Autor: Miren Zuazo, Grazyna Kochan, David Escors, M.J. García-Granda, Ana Bocanegra, L. Fernández-Rubio, Gonzalo Fernandez-Hinojal, Hugo Arasanz, E.B. Palmeiro, R. Vera, Pilar Morente, Miriam Echaide, Maider Garnica, Luisa Chocarro, Pablo Ramos

Publikováno v: Annals of Oncology. 32:S365-S366

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c830e3e9fa128fd8b36c6a509f0fc5bc
https://doi.org/10.1016/j.annonc.2021.08.295

A Proteomic Atlas of Lineage and Cancer-Polarized Expression Modules in Myeloid Cells Modeling Immunosuppressive Tumor-Infiltrating Subsets

Autor: Maider Garnica, Ana Bocanegra, Joaquín Fernández-Irigoyen, Maria Gato, Karina Ausín, Martin R. Larsen, E. Blanco, David Escors, Gonzalo Fernandez-Hinojal, Xabier Martínez de Morentin, Hugo Arasanz, Pilar Morente, Enrique Santamaría, Luisa Chocarro, María Ibáñez-Vea, Miriam Echaide, Grazyna Kochan, Carlos Hernandez, Diana Llopiz, Leticia Fernandez, Cristian Smerdou, Pablo Ramos-Castellanos, Lylia Drici, Miren Zuazo

Publikováno v: Blanco, E, Ibañez-Vea, M, Hernandez, C, Drici, L, de Morentin, X M, Gato, M, Ausin, K, Bocanegra, A, Zuazo, M, Chocarro, L, Arasanz, H, Fernandez-Hinojal, G, Fernandez-Irigoyen, J, Smerdou, C, Garnica, M, Echaide, M, Fernandez, L, Morente, P, Ramos-Castellanos, P, Llopiz, D, Santamaria, E, Larsen, M R, Escors, D & Kochan, G 2021, ' A Proteomic Atlas of Lineage and Cancer-Polarized Expression Modules in Myeloid Cells Modeling Immunosuppressive Tumor-Infiltrating Subsets ', Journal of Personalized Medicine, vol. 11, no. 6, 542 . https://doi.org/10.3390/jpm11060542
Journal of Personalized Medicine, Vol 11, Iss 542, p 542 (2021)
Blanco, E, Ibañez-Vea, M, Hernandez, C, Drici, L, de Morentin, X M, Gato, M, Ausin, K, Bocanegra, A, Zuazo, M, Chocarro, L, Arasanz, H, Fernandez-Hinojal, G, Fernandez-Irigoyen, J, Smerdou, C, Garnica, M, Echaide, M, Fernandez, L, Morente, P, Ramos-Castellanos, P, Llopiz, D, Santamaria, E, Larsen, M R, Escors, D & Kochan, G 2021, ' A proteomic atlas of lineage and cancer-polarized expression modules in myeloid cells modeling immunosuppressive tumor-infiltrating subsets ', Journal of Personalized Medicine, vol. 11, no. 6, 542 . https://doi.org/10.3390/jpm11060542
Journal of Personalized Medicine
Volume 11
Issue 6
Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
instname

Monocytic and granulocytic myeloid-derived suppressor cells together with tumor-infiltrating macrophages constitute the main tumor-infiltrating immunosuppressive myeloid populations. Due to the phenotypic resemblance to conventional myeloid cells, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a41ce218112a3b29f97a96e6e67f1b17
https://curis.ku.dk/ws/files/273751320/jpm_11_00542.pdf