Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Pilar Martinez Martinez"'
Autor:
Dongrui Li, Shenghua Zong, Yaobing Yao, Peter C. Molenaar, Jan G. M. C. Damoiseaux, Hui Li, Rob P. W. Rouhl, Pilar Martinez-Martinez
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionAnti-GABABR encephalitis is a rare disease reported to be often associated with tumors. The current study aims to summarize the clinical characteristics, imaging features, treatments, outcomes and explore the potential prognosis risk fact
Externí odkaz:
https://doaj.org/article/b34a6d8fb4414c7abfe07ed2a84501a6
Autor:
Inga Koneczny, Marina Mané-Damas, Shenghua Zong, Sander De Haas, Saif Huda, Daan van Kruining, Jan Damoiseaux, Anna De Rosa, Michelangelo Maestri, Melania Guida, Peter Molenaar, Philip Van Damme, Andreas Fichtenbaum, Thomas Perkmann, Marc De Baets, Konstantinos Lazaridis, Vasiliki Zouvelou, Socrates Tzartos, Roberta Ricciardi, Mario Losen, Pilar Martinez-Martinez
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionMuscle-specific kinase (MuSK)- myasthenia gravis (MG) is caused by pathogenic autoantibodies against MuSK that correlate with disease severity and are predominantly of the IgG4 subclass. The first-line treatment for MuSK-MG is general imm
Externí odkaz:
https://doaj.org/article/c2c004998c4f40fd8460fa0a2d8a4cfa
Autor:
Miriam L. Fichtner, Kenneth B. Hoehn, Easton E. Ford, Marina Mane-Damas, Sangwook Oh, Patrick Waters, Aimee S. Payne, Melissa L. Smith, Corey T. Watson, Mario Losen, Pilar Martinez-Martinez, Richard J. Nowak, Steven H. Kleinstein, Kevin C. O’Connor
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-16 (2022)
Abstract Myasthenia gravis (MG) is an autoantibody-mediated autoimmune disorder of the neuromuscular junction. A small subset of patients (
Externí odkaz:
https://doaj.org/article/8b2f0e5081c74f97a58e8de4171c3ffb
Autor:
Daan vanKruining, Mario Losen, Simone M. Crivelli, Joost J. A. deJong, Jacobus F. A. Jansen, Walter H. Backes, Jennifer Monereo‐Sánchez, Martin P. J. vanBoxtel, Sebastian Köhler, David E. J. Linden, Miranda T. Schram, Michelle M. Mielke, Pilar Martinez‐Martinez
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 15, Iss 3, Pp n/a-n/a (2023)
Abstract Introduction There is an urgent need for biomarkers identifying individuals at risk of early‐stage cognitive impairment. Using cross‐sectional data from The Maastricht Study, this study included 197 individuals with mild cognitive impair
Externí odkaz:
https://doaj.org/article/a188817f504247eb896e38e9abae158a
Autor:
Shenghua Zong, Anita M. Vinke, Peng Du, Carolin Hoffmann, Marina Mané-Damas, Peter C. Molenaar, Jan G. M. C. Damoiseaux, Mario Losen, Rob P. W. Rouhl, Pilar Martinez-Martinez
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
BackgroundAnti-GAD65 autoantibodies (GAD65-Abs) may occur in patients with epilepsy and other neurological disorders, but the clinical significance is not clear-cut. Whereas high levels of GAD65-Abs are considered pathogenic in neuropsychiatric disor
Externí odkaz:
https://doaj.org/article/62190aee9c6d4b1bba7be6382561a565
Autor:
Simone M. Crivelli, Qian Luo, Daan van Kruining, Caterina Giovagnoni, Marina Mané-Damas, Sandra den Hoedt, Dusan Berkes, Helga E. De Vries, Monique T. Mulder, Jochen Walter, Etienne Waelkens, Rita Derua, Johannes V. Swinnen, Jonas Dehairs, Erwin P.M. Wijnands, Erhard Bieberich, Mario Losen, Pilar Martinez-Martinez
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 152, Iss , Pp 113240- (2022)
The protection mediated by the bioactive sphingolipid sphingosine-1-phosphate (S1P) declines during Alzheimer’s disease (AD) progression, especially in patients carrying the apolipoprotein E ε4 (APOE4) isoform. The drug FTY720 mimics S1P bioactivi
Externí odkaz:
https://doaj.org/article/58772434b0eb4fa8b58df691f00ff518
Autor:
Simone M. Crivelli, Caterina Giovagnoni, Zhihui Zhu, Priyanka Tripathi, Ahmed Elsherbini, Zainuddin Quadri, Jian Pu, Liping Zhang, Branislav Ferko, Dusan Berkes, Stefka D. Spassieva, Pilar Martinez‐Martinez, Erhard Bieberich
Publikováno v:
Journal of Extracellular Vesicles, Vol 11, Iss 6, Pp n/a-n/a (2022)
Abstract The formation of extracellular vesicles (EVs) is induced by the sphingolipid ceramide. How this pathway is regulated is not entirely understood. Here, we report that the ceramide transport protein (CERT) mediates a non‐vesicular transport
Externí odkaz:
https://doaj.org/article/35b1989cf24d4976b8e5455fb4bc0a1f
Autor:
Simone M. Crivelli, Qian Luo, Jo A.A. Stevens, Caterina Giovagnoni, Daan van Kruining, Gerard Bode, Sandra den Hoedt, Barbara Hobo, Anna-Lena Scheithauer, Jochen Walter, Monique T. Mulder, Christopher Exley, Matthew Mold, Michelle M. Mielke, Helga E. De Vries, Kristiaan Wouters, Daniel L. A. van den Hove, Dusan Berkes, María Dolores Ledesma, Joost Verhaagen, Mario Losen, Erhard Bieberich, Pilar Martinez-Martinez
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-21 (2021)
Abstract Background Dysregulation of ceramide and sphingomyelin levels have been suggested to contribute to the pathogenesis of Alzheimer’s disease (AD). Ceramide transfer proteins (CERTs) are ceramide carriers which are crucial for ceramide and sp
Externí odkaz:
https://doaj.org/article/d634c5d563fa46608f8877609d288d6f
Autor:
Inga Koneczny, John Tzartos, Marina Mané-Damas, Vuslat Yilmaz, Maartje G. Huijbers, Konstantinos Lazaridis, Romana Höftberger, Erdem Tüzün, Pilar Martinez-Martinez, Socrates Tzartos, Frank Leypoldt
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Organ-specific autoimmunity is often characterized by autoantibodies targeting proteins expressed in the affected tissue. A subgroup of autoimmunopathies has recently emerged that is characterized by predominant autoantibodies of the IgG4 subclass (I
Externí odkaz:
https://doaj.org/article/78bc7e200402401ba9ded1519de3fce1
Autor:
Shenghua Zong, Carolin Correia-Hoffmann, Marina Mané-Damas, Nils Kappelmann, Peter C. Molenaar, Gerard van Grootheest, Brenda W. J. H. Penninx, Rob P. W. Rouhl, Mario Losen, Pilar Martinez-Martinez
Publikováno v:
Translational Psychiatry, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract Neuronal surface autoantibodies (NSAbs) against various antigens cause autoimmune encephalitis. Some of these antigens are also involved in the pathology of depression and anxiety. To study whether NSAbs are more common in plasma of individu
Externí odkaz:
https://doaj.org/article/240d500885514bb29fd914fbca3859eb