Inhibition of PKCε induces primordial germ cell reprogramming into pluripotency by HIF12 upregulation and histone acetylation

Autor: Adrian, Moratilla, Diego, Sainz de la Maza, Marta, Cadenas Martin, Pilar, López-Iglesias, Pilar, González-Peramato, Maria P, De Miguel

Publikováno v: Am J Stem Cells

Historically, primordial germ cells (PGCs) have been a good model to study pluripotency. Despite their low numbers and limited accessibility in the mouse embryo, they can be easily and rapidly reprogrammed at high efficiency with external physicochem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c32c985499f9a02bb980847f5fdbeb2d
https://pubmed.ncbi.nlm.nih.gov/33815934

Hypoxia induces pluripotency in primordial germ cells by HIF1α stabilization and Oct4 deregulation

Autor: Hans R. Schöler, Yago Alcaina, Natalia Tapia, Analia Nunez O'Mara, Edurne Berra, Davood Sabour, Peter J. Donovan, Manuel Nistal, Pilar López-Iglesias, Marcos J. Araúzo-Bravo, Maria P. De Miguel, Diego Sainz de la Maza, Sagrario Ortega

Publikováno v: Antioxidantsredox signaling. 22(3)

To study the mechanisms of pluripotency induction, we compared gene expression in pluripotent embryonic germ cells (EGCs) and unipotent primordial germ cells (PGCs).We found 11 genes ≥1.5-fold overexpressed in EGCs. None of the genes identified was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71f58550f17419f01a0585998805ab14
https://pubmed.ncbi.nlm.nih.gov/25226357

Short and long term fate of human AMSC subcutaneously injected in mice

Autor: Pilar, López-Iglesias, Alejandro, Blázquez-Martínez, Jorge, Fernández-Delgado, Javier, Regadera, Manuel, Nistal, Maria P De, Miguel

Publikováno v: World journal of stem cells. 3(6)

To study the ability of human adipose-derived mesenchymal stem cells (AMSCs) to survive over the short and long term, their biodistribution and their biosafety in vivo in tumor-prone environments.We subcutaneously injected human AMSCs from different

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::db26de72491e99c0458854d6d38aae04
https://pubmed.ncbi.nlm.nih.gov/21860670

Short and long term fate of human AMSC subcutaneously injected in mice.

Autor: López-Iglesias P; Pilar López-Iglesias, Alejandro Blázquez-Martínez, Maria P De Miguel, Cell Engineering Laboratory, IdiPaz, La Paz Hospital Research Institute, Madrid 28046, Spain., Blázquez-Martínez A, Fernández-Delgado J, Regadera J, Nistal M, Miguel MP

Publikováno v: World journal of stem cells [World J Stem Cells] 2011 Jun 26; Vol. 3 (6), pp. 53-62.