961 Preliminary results of a phase 2 study of intratumoral administration of BO-112 with pembrolizumab in patients with advanced melanoma that have progressive disease on anti-PD-1-based therapy

Autor: Roberto Martin Huertas, Stéphane Dalle, Juan Martin-Liberal, Sorilla Prey, Caroline Dutriaux, Henry Montaudie, Marisol Quintero, Philippe Saiag, Juan Francisco Rodriguez-Moreno, Enrique de Miguel, Julie Charles, Eva Muñoz Couselo, Alfonso Berrocal, Maria Gonzalez Cao, Elisa Funk-Brentano, Delvys Rodriguez Abreu, Eduardo Castanon Alvarez, Helena Escuin-Ordinas, Javier Sánchez López, Caroline Robert, Ana Arance, María Pilar López Criado, Luis Merino, Pablo Cerezuela-Fuentes, Ivan Marquez Rodas, Sonia Maciá, Marya F. Chaney, Miguel F. Sanmamed

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

BackgroundIntratumoral immunotherapies are being tested in different solid tumors. They trigger local and systemic responses.1 2 BO-112 is a double stranded RNA nanoplexed with polyethyleneimine (PEI), which mimics a viral infection and mobilizes the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e402ca5ac12d03a7ed527395e7f52c31
https://doaj.org/article/cfa232992c194eb9b490f0ff34e0deec

Abstract CT109: Radiomic features in tumor assessment, preliminary results from a phase 2 study of intratumoral administration of BO-112 with pembrolizumab in patients with anti PD1 refractory melanoma

Autor: Paula Moreno, Philippe Saiag, Luis de la Cruz Merino, Caroline Dutriaux, Eduardo Castanon Álvarez, Caroline Robert, Juan F. Rodríguez-Moreno, Pablo Cerezuela-Fuentes, Ana M. Arance, Henry Montaudié, Miguel F. Sanmamed, María González Cao, María Pilar López Criado, Julie Charles, Alfonso Berrocal, Enrique de Miguel, Elisa Funk-Brentano, Pablo Sau Llanas, Sorilla Prey, Eva Muñoz-Couselo, Delvys Rodríguez Abreu, Juan Martin-Liberal, Ángel Alberich-Bayarri, Javier Sánchez López, Sonia Macia, Marisol Quintero, Marya F. Chaney, Stéphane Dalle, Iván Márquez-Rodas

Publikováno v: Cancer Research. 82:CT109-CT109

Background: There is a lack of predictive biomarkers for immunotherapy in melanoma. Immunohistochemistry and gene sequencing are frequently assessed as part of clinical research. Radiomic signatures may also add valuable information, based on paramet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f29966c2df19670f816ad4c8c8d4e9e1
https://doi.org/10.1158/1538-7445.am2022-ct109

Efficacy and safety of lurbinectedin and doxorubicin in relapsed small cell lung cancer. Results from an expansion cohort of a phase I study

Autor: J.A. Lopez-Vilariño, Victor Moreno, Rafael Nuñez, Michael Flynn, Carmen Kahatt, Martin Forster, Irene Brana, Maria Eugenia Olmedo, Bernard Doger, Ali Zeaiter, Maria de Miguel, Emiliano Calvo, Martin Cullell-Young, María Pilar López-Criado

Publikováno v: Investigational New Drugs
Scientia

SummaryBackground A phase I study found remarkable activity and manageable toxicity for doxorubicin (bolus) plus lurbinectedin (1-h intravenous [i.v.] infusion) on Day 1 every three weeks (q3wk) as second-line therapy in relapsed small cell lung canc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::504713d6638c193ee1e101c7e76e1baf
https://pubmed.ncbi.nlm.nih.gov/33704620

Radium-223 international early access program: results from the Spanish subset

Autor: Luis León, Jose Angel Arranz, Alvaro Pinto, Jesus Garcia Donas, Pilar López-Criado, Mª Isabel Sáez, Joan Carles, Mª José Méndez, Marta López-Brea, Gaspar Reynés, Begoña Mellado, Cristina Moretones, Begoña Perez-Valderrama, Jose Luis Perez-Gracia, Aranzazu Gonzalez del Alba, Pablo Maroto, Josep R Germà, Nuria Lainez, Emilio Esteban, Daniel Castellano, S. Hernando

Publikováno v: Future Oncology
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
FUTURE ONCOLOGY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe

Aim: To report results from the Spanish subset included in the radium-223 international early access program (iEAP). Patients & methods: Ninety patients with castration-resistant prostate cancer and bone metastases received radium-223 55 kBq/kg every

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40d321ab4880ea170c03313002fd5665
https://doi.org/10.2217/fon-2017-0297

Safety and effectiveness of vinflunine in patients with metastatic transitional cell carcinoma of the urothelial tract after failure of one platinum-based systemic therapy in clinical practice

Autor: O. Fernández, María Belén González, Guillermo de Velasco, Enrique Grande, Javier Puente, Isabel Chirivella, Pilar López-Criado, Iciar García-Carbonero, Nicolas Mohedano, Daniel Castellano

Publikováno v: BMC Cancer

Background: Patients with transitional cell carcinoma of the urothelial tract (TCCU) who fail initial platinum-based chemotherapy for advanced disease represent a challenge in daily clinical practice. Vinflunine is approved by the European Medicine A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6fa19b95e71135756676e1a6a145aa8
https://doi.org/10.1186/1471-2407-14-779