Thyroid hormone regulation of gene expression in primary cerebrocortical cells: role of thyroid hormone receptor subtypes and interactions with retinoic acid and glucocorticoids.

Autor: Pilar Gil-Ibáñez, Juan Bernal, Beatriz Morte

Publikováno v: PLoS ONE, Vol 9, Iss 3, p e91692 (2014)

The effects of thyroid hormone on brain development and function are largely mediated by the binding of 3,5,3'-triiodo-L-thyronine (T3) to its nuclear receptors (TR) to regulate positively or negatively gene expression. We have analyzed by quantitati

Externí odkaz: https://doaj.org/article/41a275efc6284791a3750c0cb5da068a

Is the Intrinsic Genomic Activity of Thyroxine Relevant In Vivo? Effects on Gene Expression in Primary Cerebrocortical and Neuroblastoma Cells

Autor: Juan Bernal, María Jesús Obregón, Beatriz Morte, Pilar Gil-Ibáñez, Mónica M. Belinchón

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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[Background]: The possibility that the intrinsic genomic activity of thyroxine (T4) is of physiological relevance has been frequently hypothesized. It might explain gene expression patterns in the brain found in type 2-deiodinase (Dio2)-deficient mic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e8ada59dcd9b0dfade6a2aa916cde40
https://pubmed.ncbi.nlm.nih.gov/28605984

Thyroid hormone regulation of gene expression in primary cerebrocortical cells: role of thyroid hormone receptor subtypes and interactions with retinoic acid and glucocorticoids

Autor: Beatriz Morte, Juan Bernal, Pilar Gil-Ibáñez

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS ONE
PLoS ONE, Vol 9, Iss 3, p e91692 (2014)

This is an open-access article distributed under the terms of the Creative Commons Attribution License.
The effects of thyroid hormone on brain development and function are largely mediated by the binding of 3,5,3′-triiodo-L-thyronine (T3) to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da76b1278209c8d12d8d86c09e30140e
http://hdl.handle.net/10261/124200

Changes in thyroid status during perinatal development of MCT8-deficient male mice

Autor: Roy E. Weiss, Pilar Gil-Ibáñez, Alexandra M. Dumitrescu, Alfonso Massimiliano Ferrara, Juan Bernal, Xiao Hui Liao, Teresa Marcinkowski, Samuel Refetoff

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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et al.
Patients with the monocarboxylate transporter 8 (MCT8) deficiency syndrome present with a severe psychomotor retardation and abnormal serum thyroid hormone (TH) levels, consisting of high T3 and low T4 and rT 3. Mice deficient in Mct8 rep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d504af7f6d2e3eb9c7fdde5b39120b
http://hdl.handle.net/10261/123850

Global Transcriptome Analysis of Primary Cerebrocortical Cells: Identification of Genes Regulated by Triiodothyronine in Specific Cell Types

Autor: Joaquín Dopazo, Francisco García-García, Pilar Gil-Ibáñez, Beatriz Morte, Juan Bernal

Publikováno v: Europe PubMed Central
CEREBRAL CORTEX
r-FISABIO. Repositorio Institucional de Producción Científica
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Digital.CSIC. Repositorio Institucional del CSIC
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)

Trabajo presentado al 3rd Symposium on Biomedical Research: "Advances and Perspectives in Neuroscience", celebrado en la Universidad Autónoma de Madrid el 22 de abril de 2016.
Thyroid hormones, thyroxine, and triiodothyronine (T3) are crucial f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6361510f9b531de4e6b6a78484338d02
http://europepmc.org/abstract/med/26534908