Výsledky vyhledávání - "Pilar García-Gascó"

Switch from Ritonavir-Boosted to Unboosted Atazanavir Guided by Therapeutic Drug Monitoring

Autor: Pilar García-Gascó, Eugenia Vispo, Sonia Rodriguez-Novoa, Judit Morello, Ivana Maida, Inmaculada Jiménez-Nácher, Pablo Barreiro, Gema González-Pardo, Antonio Parra, Vincent Soriano

Publikováno v: AIDS Research and Human Retroviruses. 24:821-825

Plasma concentration of atazanavir (ATV) may be reduced when coadministered with tenofovir (TDF) or proton pump inhibitors. Boosting ATV exposure with ritonavir (r) may make it possible to overcome these drug interactions. However, jaundice and loss

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02fda500b7c8b32aaa348caabb3c85e5
https://doi.org/10.1089/aid.2007.0276

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Evidence for different susceptibility to tipranavir and darunavir in patients infected with distinct HIV-1 subtypes

Autor: Pilar García-Gascó, Neil Parkin, Sunny Choe, Vincent Soriano, Eva Poveda, Carmen de Mendoza, Angélica Corral

Publikováno v: AIDS. 22:611-616

BACKGROUND Tipranavir (TPV) and darunavir (DRV) are potent against protease inhibitor (PI)-resistant viruses. Efficacy of these compounds when confronting distinct HIV subtypes is not known. METHODS All clinical specimens from HIV-positive patients s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72a44d3dffad78bd5a937fd24bb382a5
https://doi.org/10.1097/qad.0b013e3282f51eb9

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Hepatotoxicity of Antiretroviral Drugs Is Reduced after Successful Treatment of Chronic Hepatitis C in HIV‐Infected Patients

Autor: Vicente Soriano, Javier Pinilla, Pilar García-Gascó, Luz Martín-Carbonero, Ivana Maida, Pablo Labarga, M. E. Vispo, Rebeca Vidal Casado, Pablo Barreiro, Carol Castellares

Publikováno v: The Journal of Infectious Diseases. 196:670-676

The risk of liver toxicity during antiretroviral drug use in human immunodeficiency virus (HIV)-positive patients increases in the presence of chronic hepatitis C virus (HCV) infection. It is unknown whether sustained HCV clearance after interferon (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8fdc0ac79bc491dc09aaa60663537e2
https://doi.org/10.1086/520092

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Value of the HLA-B*5701 Allele to Predict Abacavir Hypersensitivity in Spaniards

Autor: Pilar García-Gascó, Gema González-Pardo, Juan González-Lahoz, Carol Castellares, Vincent Soriano, Francisco J. Blanco, Sonia Rodriguez-Novoa, Inmaculada Jiménez-Nácher, Victoria Moreno

Publikováno v: AIDS Research and Human Retroviruses. 23:1374-1376

The use of abacavir (ABC) may be associated with a hypersensitivity reaction (HSR) that requires discontinuation of the drug. The HLA-B*5701 allele has been linked to this HSR. Information on the strength of this association across distinct geographi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ec40ef42a1cbcfcd76564fcad8114e
https://doi.org/10.1089/aid.2006.0244

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Successful rescue therapy with darunabir (TMC114) in HIV-infected patients who have failed several ritonavir-boosted protease inhibitors

Autor: Vincent Soriano, Antonio Alcolea, Francisco J. Blanco, Eva Poveda, Verónica Briz, Pilar García-Gascó

Publikováno v: AIDS. 20:1558-1560

Darunabir, formerly TMC114, is a new protease inhibitor (PI) under clinical development designed to be active against HIV strains resistant to currently available PI. The virological and immunological response to ritonavir-boosted darunabir was asses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51366d17f8fbb83b997f9706f41f8172
https://doi.org/10.1097/01.aids.0000237375.23692.f4

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Level, phenotype and activation status of CD4+FoxP3+ regulatory T cells in patients chronically infected with human immunodeficiency virus and/or hepatitis C virus

Autor: Pilar García-Gascó, Pablo Labarga, Javier García-Samaniego, Vincent Soriano, José M. Benito, Norma Rallón, Miriam Romero, Mariola López, Juan González-Lahoz

Summary CD4+ regulatory T (Treg) cells have been involved in impaired immunity and persistence of viral infections. Herein, we report the level, phenotype and activation status of Treg cells in patients chronically infected with human immunodeficienc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e3da874fbb2f8addc0d677e68befb0a
https://europepmc.org/articles/PMC2665677/

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Predictors of severe hepatic steatosis using abdominal ultrasound in HIV-infected patients

Autor: Vincent Soriano, Juan González-Lahoz, Pilar García-Gascó, Pablo Labarga, Eugenia Vispo, Pablo Ryan, Pablo Barreiro, JA García-Merchán, Francisco J. Blanco

Publikováno v: HIV medicine. 10(1)

Objective Multiple factors may lead to hepatic steatosis (HS) in HIV-positive patients. HS may result in severe liver damage on its own and/or by accelerating the progression of chronic viral hepatitis B or C. Methods The sensitivity/specificity of l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e8c91f843273a723e155f17c3b4bd03
https://pubmed.ncbi.nlm.nih.gov/19018879

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Distinct hepatitis C virus kinetics in HIV-infected patients treated with ribavirin plus either pegylated interferon alpha2a or alpha2b

Autor: Eugenia, Vispo, Pablo, Barreiro, Sonia, Rodriguez-Nóvoa, Judit, Morello, Pablo, Labarga, Luz, Martín-Carbonero, Ivana, Maida, Pilar, García-Gascó, Vincent, Soriano

Publikováno v: Antiviral therapy. 13(4)

Pegylated interferon (PEG-IFN) alpha2a and alpha2b differ in their pharmacokinetic properties, which might have an effect on their antiviral effects against hepatitis C virus (HCV). Differences between PEG-IFN-alpha molecules could be more pronounced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7d7b4780a2a15b9ceb2fc0a5a009a840
https://pubmed.ncbi.nlm.nih.gov/18672529

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Liver fibrosis on account of chronic hepatitis C is more severe in HIV-positive than HIV-negative patients despite antiretroviral therapy

Autor: V. de Ledinghen, Luz Martín-Carbonero, Juliette Foucher, Vincent Soriano, Pablo Labarga, Pilar García-Gascó, M. E. Vispo, Laurent Castera, Wassil Merrouche, Didier Neau, Pablo Barreiro, Pierre-Henri Bernard

Publikováno v: Journal of viral hepatitis. 15(6)

The recent availability of non-invasive tools to measure liver fibrosis has allowed examination of its extent and determination of predictors in all patients with chronic hepatitis C virus (HCV) infection. On the other hand, most information on hepat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a2a12db358eca3884e8a2b4606e2b1
https://pubmed.ncbi.nlm.nih.gov/18221303

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Episodes of low-level viral rebound in HIV-infected patients on antiretroviral therapy: frequency, predictors and outcome

Autor: Pilar García-Gascó, Eugenia Vispo, Luz Martín-Carbonero, Vincent Soriano, Juan González-Lahoz, Pablo Barreiro, Ivana Maida, Francisco J. Blanco

Publikováno v: The Journal of antimicrobial chemotherapy. 61(3)

The rate, predictors and outcome following episodes of low-level viral rebound (LLVR) in HIV patients on highly active antiretroviral therapy (HAART) are unknown.Retrospective assessment of all HIV patients who experienced LLVR episodes on HAART at o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9969aa0c97699374ea8dfc374075f92b
https://pubmed.ncbi.nlm.nih.gov/18192682

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