miR-126 contributes to the epigenetic signature of diabetic vascular smooth muscle and enhances antirestenosis effects of Kv1.3 blockers

Autor: Marycarmen Arevalo-Martinez, Pilar Cidad, Sara Moreno-Estar, Mirella Fernández, Sebastian Albinsson, Irene Cózar-Castellano, José R. López-López, M. Teresa Pérez-Garcia

Publikováno v: Molecular Metabolism, Vol 53, Iss , Pp 101306- (2021)

Objectives: Restenosis after vessel angioplasty due to dedifferentiation of the vascular smooth muscle cells (VSMCs) limits the success of surgical treatment of vascular occlusions. Type 2 diabetes (T2DM) has a major impact on restenosis, with patien

Externí odkaz: https://doaj.org/article/e00a9e75cdf44eabb6c98499dacf5b54

Proliferative Role of Kv11 Channels in Murine Arteries

Autor: Vincenzo Barrese, Pilar Cidad, Shuk Y. Yeung, Jose R. López-López, Alister J. McNeish, Susumu Ohya, Maria T. Pérez-García, Iain A. Greenwood

Publikováno v: Frontiers in Physiology, Vol 8 (2017)

K+ channels encoded by the ether-a-go-go related gene (ERG1 or KCNH2) are important determinants of the cardiac action potential. Expression of both cardiac isoforms (ERG1a and ERG1b) were identified in murine portal vein and distinctive voltage-gate

Externí odkaz: https://doaj.org/article/9d890720e5ca40d9a278f356c59f4f89

Kv1.3 blockade inhibits proliferation of vascular smooth muscle cells in vitro and intimal hyperplasia in vivo

Autor: José R. López-López, Montserrat Rigol, Núria Solanes, Felipe Fernández-Vázquez, Claudia Pérez-Martínez, Joaquim Bobi, Manel Sabaté, Mercè Roqué, Victor Ramos-Pérez, Mª Teresa Pérez-García, Alberto Ponce, Xavier Freixa, Manel Garabito, Salvador Borrós, Armando Pérez de Prado, Pilar Cidad

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

© 2020 Published by Elsevier Inc
The modulation of voltage-gated K+ (Kv) channels, involved in cell proliferation, arises as a potential therapeutic approach for the prevention of intimal hyperplasia present in in-stent restenosis (ISR) and all

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32bb00fc7a81049a598faef178cb8a6e
https://doi.org/10.1016/j.trsl.2020.06.002

Tungstate-targeting of BKαβ1 channels tunes ERK phosphorylation and cell proliferation in human vascular smooth muscle.

Autor: Ana Isabel Fernández-Mariño, Pilar Cidad, Delia Zafra, Laura Nocito, Jorge Domínguez, Aida Oliván-Viguera, Ralf Köhler, José R López-López, María Teresa Pérez-García, Miguel Ángel Valverde, Joan J Guinovart, José M Fernández-Fernández

Publikováno v: PLoS ONE, Vol 10, Iss 2, p e0118148 (2015)

Despite the substantial knowledge on the antidiabetic, antiobesity and antihypertensive actions of tungstate, information on its primary target/s is scarce. Tungstate activates both the ERK1/2 pathway and the vascular voltage- and Ca2+-dependent larg

Externí odkaz: https://doaj.org/article/25b697aef0f54fd5af54d19183c72a86

Pancreatic β-cell-specific deletion of insulin-degrading enzyme leads to dysregulated insulin secretion and β-cell functional immaturity

Autor: Pilar Cidad, Beatriz Merino, José F. López-Acosta, Carmen D. Lobatón, Germán Perdomo, Alfredo Moreno, Cristina M. Fernández-Díaz, Miguel Angel de la Fuente, Malcolm A. Leissring, Irene Cózar-Castellano

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Am J Physiol Endocrinol Metab
Repositorio Institucional de la Universidad de Burgos (RIUBU)
Universidad de Burgos (UBU)
Universidad de Almería

Inhibition of insulin-degrading enzyme (IDE) has been proposed as a possible therapeutic target for type 2 diabetes treatment. However, many aspects of IDE's role in glucose homeostasis need to be clarified. In light of this, new preclinical models a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1317494187086fa6dd3230890b4936e5
https://doi.org/10.1152/ajpendo.00040.2019