Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Pilar, Areso"'
Autor:
Alvaro Villarroel, Carolina Gomis-Perez, Maria V. Soldovieri, Covadonga Malo, Paolo Ambrosino, Maurizio Taglialatela, Pilar Areso
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
HIGHLIGHTS- Calmodulin-dependent Kv7.2 current density without the need of binding calcium.- Kv7.2 current density increase is accompanied with resistance to PI(4,5)P2 depletion.- Kv7.3 current density is insensitive to calmodulin elevation.- Kv7.3 i
Externí odkaz:
https://doaj.org/article/f109c741dcd64703a5ee752807ae837a
Autor:
Alessandro Alaimo, Araitz Alberdi, Carolina Gomis-Perez, Juncal Fernández-Orth, Ganeko Bernardo-Seisdedos, Covadonga Malo, Oscar Millet, Pilar Areso, Alvaro Villarroel
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86711 (2014)
Kv7.2 (KCNQ2) is the principal molecular component of the slow voltage gated M-channel, which strongly influences neuronal excitability. Calmodulin (CaM) binds to two intracellular C-terminal segments of Kv7.2 channels, helices A and B, and it is req
Externí odkaz:
https://doaj.org/article/dca1fc06521041f5b0972c7720bcbb4a
Autor:
Juan Camilo Gómez-Posada, Paloma Aivar, Araitz Alberdi, Alessandro Alaimo, Ainhoa Etxeberría, Juncal Fernández-Orth, Teresa Zamalloa, Meritxell Roura-Ferrer, Patricia Villace, Pilar Areso, Oscar Casis, Alvaro Villarroel
Publikováno v:
PLoS ONE, Vol 9, Iss 1 (2014)
Externí odkaz:
https://doaj.org/article/ba4caedb7f83462ba7e4962b171ad256
Autor:
Paloma Aivar, Juncal Fernández-Orth, Carolina Gomis-Perez, Araitz Alberdi, Alessandro Alaimo, Manuel S Rodríguez, Teresa Giraldez, Pablo Miranda, Pilar Areso, Alvaro Villarroel
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47263 (2012)
Kv7.2 and Kv7.3 are the main components of the neuronal voltage-dependent M-current, which is a subthreshold potassium conductance that exerts an important control on neuronal excitability. Despite their predominantly intracellular distribution, thes
Externí odkaz:
https://doaj.org/article/03b2e166e5c6489d990b8c77d87459e1
Autor:
Juan Camilo Gómez-Posada, Paloma Aivar, Araitz Alberdi, Alessandro Alaimo, Ainhoa Etxeberría, Juncal Fernández-Orth, Teresa Zamalloa, Meritxell Roura-Ferrer, Patricia Villace, Pilar Areso, Oscar Casis, Alvaro Villarroel
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e25508 (2011)
M-channels are voltage-gated potassium channels composed of Kv7.2-7.5 subunits that serve as important regulators of neuronal excitability. Calmodulin binding is required for Kv7 channel function and mutations in Kv7.2 that disrupt calmodulin binding
Externí odkaz:
https://doaj.org/article/47f14168dbc140f4a0aa702577b670ff
Autor:
Carolina, Gomis-Perez, Maria V, Soldovieri, Covadonga, Malo, Paolo, Ambrosino, Maurizio, Taglialatela, Pilar, Areso, Alvaro, Villarroel
Publikováno v:
Frontiers in Molecular Neuroscience
HIGHLIGHTS - Calmodulin-dependent Kv7.2 current density without the need of binding calcium.- Kv7.2 current density increase is accompanied with resistance to PI(4,5)P2 depletion.- Kv7.3 current density is insensitive to calmodulin elevation.- Kv7.3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::50d04ed9a643b5c9c59ee85997d05728
https://pubmed.ncbi.nlm.nih.gov/28507506
https://pubmed.ncbi.nlm.nih.gov/28507506
Autor:
Covadonga Malo, Paolo Ambrosino, Carolina Gomis-Perez, Maurizio Taglialatela, Alvaro Villarroel, Maria Virginia Soldovieri, Pilar Areso
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Frontiers in Molecular Neuroscience, Vol 10 (2017)
instname
Frontiers in Molecular Neuroscience, Vol 10 (2017)
HIGHLIGHTS- Calmodulin-dependent Kv7.2 current density without the need of binding calcium.- Kv7.2 current density increase is accompanied with resistance to PI(4,5)P2 depletion.- Kv7.3 current density is insensitive to calmodulin elevation.- Kv7.3 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::762726e574c792fff3217a2bee9c2e84
http://hdl.handle.net/10261/152619
http://hdl.handle.net/10261/152619
The Ever Changing Moods of Calmodulin: How Structural Plasticity Entails Transductional Adaptability
Autor:
Maria Virginia Soldovieri, Ganeko Bernardo-Seisdedos, Maurizio Taglialatela, Araitz Alberdi, Pilar Areso, Carolina Gomis-Perez, Alvaro Villarroel, Jon Agirre, Paolo Ambrosino, Covadonga Malo, Alessandro Alaimo
Publikováno v:
Journal of Molecular Biology. 426:2717-2735
The exceptional versatility of calmodulin (CaM) three-dimensional arrangement is reflected in the growing number of structural models of CaM/protein complexes currently available in the Protein Data Bank (PDB) database, revealing a great diversity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e1a7ef8c8589115027c8667f89b5cc0
https://doi.org/10.1016/j.jmb.2014.05.016
https://doi.org/10.1016/j.jmb.2014.05.016
Autor:
Oscar Millet, Pilar Areso, Carolina Gomis-Perez, Alessandro Alaimo, Ganeko Bernardo-Seisdedos, Covadonga Malo, Araitz Alberdi, Alvaro Villarroel
Publikováno v:
Biophysical Journal. 110(3)
Calmodulin (CaM), a bi-partite protein, binding to the A-B module, a bi-partite target, affect the function of Kv7.2 subunits, which are the main component of the non-inactivating K+ M-current, a key controller of neuronal excitability. Simultaneous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c69e13e5f2cca8828369190509bb51a4
Autor:
Pilar Areso, Juan Camilo Gómez-Posada, Ruth D. Murrell-Lagnado, Alvaro Villarroel, Marianela Masin, Ainhoa Etxeberria, Meritxell Roura-Ferrer
Publikováno v:
Journal of Neuroscience. 30:9316-9323
KCNQ2 (Kv7.2) and KCNQ3 (Kv7.3) are the principal subunits underlying the potassium M-current, which exerts a strong control on neuronal excitability. KCNQ3 subunits coassemble with KCNQ2 to form functional heteromeric channels that are specifically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d328c54e5d6417f7e415b147c0b9460
https://doi.org/10.1523/jneurosci.0851-10.2010
https://doi.org/10.1523/jneurosci.0851-10.2010