Zobrazeno 1 - 10
of 199
pro vyhledávání: '"Pikromycin"'
Publikováno v:
Microbial Cell Factories, Vol 16, Iss 1, Pp 1-9 (2017)
Abstract Background Heterologous expression of biosynthetic gene clusters of natural microbial products has become an essential strategy for titer improvement and pathway engineering of various potentially-valuable natural products. A Streptomyces ar
Externí odkaz:
https://doaj.org/article/679ded61601546ce80134caf3045e77d
Akademický článek
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Autor:
Xiaohui Liu, Shengying Li, Xingwang Zhang, Jiawei Guo, Wei Zhang, Gang Zhang, Li Ma, Lei Du, Fengwei Li, Fangyuan Cheng, Pradeepraj Durairaj, Dandan Tang, Xiangtian Long
Publikováno v:
The Journal of Organic Chemistry. 86:14563-14571
Human drug metabolites (HDMs) are important chemicals widely used in drug-related studies. However, acquiring these enzyme-derived and regio-/stereo-selectively modified compounds through chemical approaches is complicated. PikC is a biosynthetic P45
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02972bf0ef268aaf38843e93afcbb3af
https://doi.org/10.1021/acs.joc.1c01407
https://doi.org/10.1021/acs.joc.1c01407
Autor:
Takuya Hashimoto, Haruo Ikeda, Noritaka Kagaya, Kei Kudo, Reiko Ueoka, Hikaru Suenaga, Kazuo Shin-ya, Ikuko Kozone, Junko Hashimoto
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 85:890-894
A novel methymycin analog, 12-ketomethymycin N-oxide, was produced by the heterologous expression of the pikromycin/methymycin biosynthetic gene cluster of Streptomyces sp. AM4900 together with 12-ketomethymycin, which was only isolated by the biotra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::614f426d8f5d2c19bf6aaea4f0e37135
https://doi.org/10.1093/bbb/zbaa111
https://doi.org/10.1093/bbb/zbaa111
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
Nature Communications
Nature Communications
To harness the synthetic power of modular polyketide synthases (PKSs), many aspects of their biochemistry must be elucidated. A robust platform to study these megadalton assembly lines has not yet been described. Here, we in vitro reconstitute the ve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37929ddbe2922ab28fa69440a469e2fa
http://link.springer.com/article/10.1038/s41467-019-13811-0
http://link.springer.com/article/10.1038/s41467-019-13811-0
Publikováno v:
Journal of Visualized Experiments.
Streptomyces spp. are a major source of clinical antibiotics and industrial chemicals. Streptomyces venezuelae ATCC 10712 is a fast-growing strain and a natural producer of chloramphenicol, jadomycin, and pikromycin, which makes it an attractive cand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76009bf424620e0f124c5bd3908fb38c
https://doi.org/10.3791/63012-v
https://doi.org/10.3791/63012-v
Publikováno v:
Chem Commun (Camb)
Using the updated module boundary of polyketide assembly lines, modules from the pikromycin synthase were recombined into engineered synthases that furnish an enantiomeric pair of 2-stereocenter triketide lactones at >99% ee with yields up to 0.39 g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51dd254860b7a064620c8323ae97757c
https://europepmc.org/articles/PMC8410653/
https://europepmc.org/articles/PMC8410653/
Akademický článek
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Akademický článek
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Publikováno v:
Journal of Microbiology and Biotechnology. 29:1931-1937
The heterologous expression of the Streptomyces natural product (NP) biosynthetic gene cluster (BGC) has become an attractive strategy for the activation, titer improvement, and refactoring of valuable and cryptic NP BGCs. Previously, a Streptomyces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe730c6e8e2f5e3654c761214575682a
https://doi.org/10.4014/jmb.1909.09022
https://doi.org/10.4014/jmb.1909.09022