Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria

Autor: Andre Mu, William P. Klare, Sarah L. Baines, C. N. Ignatius Pang, Romain Guérillot, Nichaela Harbison-Price, Nadia Keller, Jonathan Wilksch, Nguyen Thi Khanh Nhu, Minh-Duy Phan, Bernhard Keller, Brunda Nijagal, Dedreia Tull, Saravanan Dayalan, Hwa Huat Charlie Chua, Dominik Skoneczny, Jason Koval, Abderrahman Hachani, Anup D. Shah, Nitika Neha, Snehal Jadhav, Sally R. Partridge, Amanda J. Cork, Kate Peters, Olivia Bertolla, Stephan Brouwer, Steven J. Hancock, Laura Álvarez-Fraga, David M. P. De Oliveira, Brian Forde, Ashleigh Dale, Warasinee Mujchariyakul, Calum J. Walsh, Ian Monk, Anna Fitzgerald, Mabel Lum, Carolina Correa-Ospina, Piklu Roy Chowdhury, Robert G. Parton, James De Voss, James Beckett, Francois Monty, Jessica McKinnon, Xiaomin Song, John R. Stephen, Marie Everest, Matt I. Bellgard, Matthew Tinning, Michael Leeming, Dianna Hocking, Leila Jebeli, Nancy Wang, Nouri Ben Zakour, Serhat A. Yasar, Stefano Vecchiarelli, Tonia Russell, Thiri Zaw, Tyrone Chen, Don Teng, Zena Kassir, Trevor Lithgow, Adam Jenney, Jason N. Cole, Victor Nizet, Tania C. Sorrell, Anton Y. Peleg, David L. Paterson, Scott A. Beatson, Jemma Wu, Mark P. Molloy, Anna E. Syme, Robert J. A. Goode, Adam A. Hunter, Grahame Bowland, Nicholas P. West, Marc R. Wilkins, Steven P. Djordjevic, Mark R. Davies, Torsten Seemann, Benjamin P. Howden, Dana Pascovici, Sonika Tyagi, Ralf B. Schittenhelm, David P. De Souza, Malcolm J. McConville, Jonathan R. Iredell, Stuart J. Cordwell, Richard A. Strugnell, Timothy P. Stinear, Mark A. Schembri, Mark J. Walker

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)

Severe sepsis has a high mortality rate. Here, the authors provide genomic, transcriptomic, proteomic and metabolomic data across four sepsis-causing pathogens and identify a signature of global increase in fatty acid and lipid biosynthesis as well a

Externí odkaz: https://doaj.org/article/6d65b18b91de403488fe5eca204df6be

Escherichia coli ST8196 is a novel, locally evolved, and extensively drug resistant pathogenic lineage within the ST131 clonal complex

Autor: Priyanka Hastak, Mathieu Fourment, Aaron E. Darling, Thomas Gottlieb, Elaine Cheong, John Merlino, Garry S. A. Myers, Steven P. Djordjevic, Piklu Roy Chowdhury

Publikováno v: Emerging Microbes and Infections, Vol 9, Iss 1, Pp 1780-1792 (2020)

ABSTRACTThe H30Rx subclade of Escherichia coli ST131 is a clinically important, globally dispersed pathogenic lineage that typically displays resistance to fluoroquinolones and extended spectrum β-lactams. Isolates EC233 and EC234, variants of ST131

Externí odkaz: https://doaj.org/article/a98f081aa3ce498eb418609a94cf5145

Correction: Alhamami et al. First Emergence of Resistance to Macrolides and Tetracycline Identified in Mannheimia haemolytica and Pasteurella multocida Isolates from Beef Feedlots in Australia. Microorganisms 2021, 9, 1322

Autor: Tamara Alhamami, Piklu Roy Chowdhury, Nancy Gomes, Mandi Carr, Tania Veltman, Manouchehr Khazandi, Joanne Mollinger, Ania T. Deutscher, Conny Turni, Layla Mahdi, Henrietta Venter, Sam Abraham, Steven P. Djordjevic, Darren J. Trott

Publikováno v: Microorganisms, Vol 10, Iss 4, p 825 (2022)

The authors wish to make the following corrections to this paper [...]

Externí odkaz: https://doaj.org/article/0881e970c6884307ba36bac857d4f7bb

First Emergence of Resistance to Macrolides and Tetracycline Identified in Mannheimia haemolytica and Pasteurella multocida Isolates from Beef Feedlots in Australia

Autor: Tamara Alhamami, Piklu Roy Chowdhury, Nancy Gomes, Mandi Carr, Tania Veltman, Manouchehr Khazandi, Joanne Mollinger, Ania T. Deutscher, Conny Turni, Layla Mahdi, Henrietta Venter, Sam Abraham, Steven P. Djordjevic, Darren J. Trott

Publikováno v: Microorganisms, Vol 9, Iss 6, p 1322 (2021)

Bovine respiratory disease (BRD) causes high morbidity and mortality in beef cattle worldwide. Antimicrobial resistance (AMR) monitoring of BRD pathogens is critical to promote appropriate antimicrobial stewardship in veterinary medicine for optimal

Externí odkaz: https://doaj.org/article/873dd0fc296f474eba411d69e100ac55

Complete Sequences of Multiple-Drug Resistant IncHI2 ST3 Plasmids in Escherichia coli of Porcine Origin in Australia

Autor: Ethan R. Wyrsch, Cameron J. Reid, Matthew Z. DeMaere, Michael Y. Liu, Toni A. Chapman, Piklu Roy Chowdhury, Steven P. Djordjevic

Publikováno v: Frontiers in Sustainable Food Systems, Vol 3 (2019)

IncHI2 ST3 plasmids are known carriers of multiple antimicrobial resistance genes. Complete plasmid sequences from multiple drug resistant Escherichia coli circulating in Australian swine is however limited. Here we sequenced two related IncHI2 ST3 p

Externí odkaz: https://doaj.org/article/618f81ddc0d24143be75cbcc46155f54