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High-Throughput Assay for Predicting Diarrhea Risk Using a 2D Human Intestinal Stem Cell-Derived Model.

Autor: Pike CM; Altis Biosystems, Durham NC, 27709, USA., Levi JA; Altis Biosystems, Durham NC, 27709, USA., Boone LA; Altis Biosystems, Durham NC, 27709, USA., Peddibhotla S; Altis Biosystems, Durham NC, 27709, USA., Johnson J; Altis Biosystems, Durham NC, 27709, USA., Zwarycz B; Altis Biosystems, Durham NC, 27709, USA., Bunger MK; Altis Biosystems, Durham NC, 27709, USA., Thelin W; Altis Biosystems, Durham NC, 27709, USA., Boazak EM; Altis Biosystems, Durham NC, 27709, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Aug 28. Date of Electronic Publication: 2024 Aug 28.

The microbial-derived bile acid lithocholate and its epimers inhibit Clostridioides difficile growth and pathogenicity while sparing members of the gut microbiota.

Autor: Kisthardt SC; Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University , Raleigh, North Carolina, USA., Thanissery R; Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University , Raleigh, North Carolina, USA., Pike CM; Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University , Raleigh, North Carolina, USA., Foley MH; Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University , Raleigh, North Carolina, USA.; Department of Food, Bioprocessing and Nutrition Sciences, College of Agriculture and Life Sciences, North Carolina State University , Raleigh, North Carolina, USA., Theriot CM; Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University , Raleigh, North Carolina, USA.

Publikováno v: Journal of bacteriology [J Bacteriol] 2023 Sep 26; Vol. 205 (9), pp. e0018023. Date of Electronic Publication: 2023 Sep 11.

Tauroursodeoxycholic Acid Inhibits Clostridioides difficile Toxin-Induced Apoptosis.

Autor: Pike CM; Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State Universitygrid.40803.3f, Raleigh, North Carolina, USA., Tam J; Molecular Medicine, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada., Melnyk RA; Molecular Medicine, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada.; SickKids Proteomics Analytics Robotics Chemical Biology Drug Discovery Facility, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada., Theriot CM; Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State Universitygrid.40803.3f, Raleigh, North Carolina, USA.

Publikováno v: Infection and immunity [Infect Immun] 2022 Aug 18; Vol. 90 (8), pp. e0015322. Date of Electronic Publication: 2022 Jul 07.

Clostridioides difficile exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiota.

Autor: Fletcher JR; Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, NC, 27607, USA., Pike CM; Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, NC, 27607, USA., Parsons RJ; Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, NC, 27607, USA., Rivera AJ; Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, NC, 27607, USA., Foley MH; Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, NC, 27607, USA., McLaren MR; Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, NC, 27607, USA., Montgomery SA; Department of Pathology and Laboratory Medicine, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Theriot CM; Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, NC, 27607, USA. cmtherio@ncsu.edu.

Publikováno v: Nature communications [Nat Commun] 2021 Jan 19; Vol. 12 (1), pp. 462. Date of Electronic Publication: 2021 Jan 19.