Underlying mechanisms of novel cuproptosis-related dihydrolipoamide branched-chain transacylase E2 (DBT) signature in sunitinib-resistant clear-cell renal cell carcinoma.

Autor: Lai SW; Division of Hematology/Oncology, Department of Internal Medicine, Tri-service General Hospital, National Defense Medical Center, Taipei, Taiwan., Weng PW; Department of Orthopaedics, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Department of Orthopaedics, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.; Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan., Yadav VK; Department of Medical Research, Taipei Medical University Shuang-Ho Hospital, Taipei, Taiwan., Pikatan NW; Department of Medical Research, Taipei Medical University Shuang-Ho Hospital, Taipei, Taiwan., Yeh CT; Department of Medical Research, Taipei Medical University Shuang-Ho Hospital, Taipei, Taiwan.; Continuing Education Program of Food Biotechnology Applications, College of Science and Engineering, National Taitung University, Taitung, Taiwan., Hsieh MS; Department of Dentistry, Taipei Medical University-Shuang Ho Hospital, New Taipei City, Taiwan.; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei City, Taiwan., Chou CL; Division of Nephrology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Taipei Medical University-Research Center of Urology and Kidney, Taipei Medical University, Taipei, Taiwan.; Division of Nephrology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei, Taiwan.; Division of Nephrology, Department of Internal Medicine, Hsin Kuo Min Hospital, Taipei Medical University, Taoyuan City, Taiwan.

Publikováno v: Aging [Aging (Albany NY)] 2024 Feb 01; Vol. 16 (3), pp. 2679-2701. Date of Electronic Publication: 2024 Feb 01.

Tumor-Associated Macrophages Affect the Tumor Microenvironment and Radioresistance via the Upregulation of CXCL6/CXCR2 in Hepatocellular Carcinoma.

Autor: Lee HL; Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.; Department of Radiation Oncology, Taipei Medical University Hospital, Taipei 11031, Taiwan.; The PhD Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taipei 11031, Taiwan., Tsai YC; Department of Radiation Oncology, Cancer Center, Taipei Medical University-Shuang Ho Hospital, New Taipei City 23561, Taiwan., Pikatan NW; Division of Urology, Department of Surgery, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia., Yeh CT; Department of Medical Research and Education, Taipei Medical University-Shuang Ho Hospital, New Taipei City 23561, Taiwan.; Continuing Education Program of Food Biotechnology Applications, College of Science and Engineering, National Taitung University, Taitung 95092, Taiwan., Yadav VK; Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Medical University-Shuang Ho Hospital, New Taipei City 23561, Taiwan., Chen MY; Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Medical University-Shuang Ho Hospital, New Taipei City 23561, Taiwan., Tsai JT; Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.; Department of Radiation Oncology, Cancer Center, Taipei Medical University-Shuang Ho Hospital, New Taipei City 23561, Taiwan.

Publikováno v: Biomedicines [Biomedicines] 2023 Jul 24; Vol. 11 (7). Date of Electronic Publication: 2023 Jul 24.

Role of GDF15/MAPK14 Axis in Chondrocyte Senescence as a Novel Senomorphic Agent in Osteoarthritis.

Autor: Weng PW; Department of Orthopaedics, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.; Department of Orthopaedics, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.; Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan., Pikatan NW; Department of Medical Research & Education, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235, Taiwan.; Division of Urology, Department of Surgery, Faculty of Medicine, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta 55281, Indonesia., Setiawan SA; Department of Medical Research & Education, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235, Taiwan.; International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei City 11031, Taiwan., Yadav VK; Department of Medical Research & Education, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235, Taiwan., Fong IH; Department of Medical Research & Education, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235, Taiwan., Hsu CH; Department of Emergency Medicine, Shuang-Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.; Graduate Institute of Injury Prevention and Control, College of Public Health, Taipei Medical University, Taipei City 11031, Taiwan., Yeh CT; Department of Medical Research & Education, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235, Taiwan.; Department of Medical Laboratory Science and Biotechnology, Yuanpei University of Medical Technology, Hsinchu City 30015, Taiwan., Lee WH; Department of Medical Research & Education, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235, Taiwan.; Department of Pathology, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2022 Jun 24; Vol. 23 (13). Date of Electronic Publication: 2022 Jun 24.

PDK1 Inhibitor BX795 Improves Cisplatin and Radio-Efficacy in Oral Squamous Cell Carcinoma by Downregulating the PDK1/CD47/Akt-Mediated Glycolysis Signaling Pathway.

Autor: Pai S; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.; Department of Oral & Maxillofacial Surgery, Saint Martin de Parres Hospital, Chiayi City 600, Taiwan., Yadav VK; Department of Medical Research and Education, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, Taiwan.; Department of Medical Laboratory Science and Biotechnology, Yuanpei University of Medical Technology, Hsinchu City 300, Taiwan., Kuo KT; Division of Thoracic Surgery, Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.; Division of Thoracic Surgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235, Taiwan., Pikatan NW; Department of Medical Research and Education, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, Taiwan.; Department of Medical Laboratory Science and Biotechnology, Yuanpei University of Medical Technology, Hsinchu City 300, Taiwan., Lin CS; Department of Radiation Oncology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan., Chien MH; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan., Lee WH; Department of Medical Research and Education, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, Taiwan.; Department of Pathology, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, Taiwan., Hsiao M; Genomics Research Center, Academia Sinica, Taipei 115, Taiwan., Chiu SC; Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan.; Translational Cell Therapy Center, Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan.; Drug Development Center, China Medical University, Taichung 404, Taiwan., Yeh CT; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.; Department of Medical Research and Education, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, Taiwan.; Department of Medical Laboratory Science and Biotechnology, Yuanpei University of Medical Technology, Hsinchu City 300, Taiwan., Tsai JT; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.; Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.; Department of Radiology, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, Taiwan.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2021 Oct 25; Vol. 22 (21). Date of Electronic Publication: 2021 Oct 25.

The E3 Ubiquitin Ligase NEDD4-1 Mediates Temozolomide-Resistant Glioblastoma through PTEN Attenuation and Redox Imbalance in Nrf2-HO-1 Axis.

Autor: Chuang HY; School of Medicine, China Medical University, Taichung 40447, Taiwan.; Translational Cell Therapy Center, Tainan Municipal An-Nan Hospital-China Medical University, Tainan 70967, Taiwan.; Division of Neurosurgery, Tainan Municipal An-Nan Hospital-China Medical University, Tainan 70967, Taiwan.; Division of Neurosurgery, China Medical University Beigang Hospital, Beigang Township 65152, Taiwan., Hsu LY; Department of Emergency Medicine, Shuang-Ho Hospital-Taipei Medical University, New Taipei City 23561, Taiwan.; Graduate Institute of Injury Prevention and Control, Taipei Medical University, Taipei 110, Taiwan.; Department of Emergency Medicine, School of Medicine, Taipei Medical University, Taipei 110, Taiwan., Pan CM; Translational Cell Therapy Center, Department of Medical Research, China Medical University Hospital, Taichung 40447, Taiwan., Pikatan NW; Doctorate Program of Medical and Health Science, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia.; Department of Medical Research and Education, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, Taiwan., Yadav VK; Department of Medical Research and Education, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, Taiwan., Fong IH; Department of Medical Research and Education, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, Taiwan., Chen CH; Biomedicine Institution, Department of Neurosurgery, China Medical University, Taichung 40447, Taiwan., Yeh CT; Department of Medical Research and Education, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, Taiwan.; Department of Medical Laboratory Science and Biotechnology, Yuanpei University of Medical Technology, Hsinchu 300, Taiwan., Chiu SC; Translational Cell Therapy Center, Department of Medical Research, China Medical University Hospital, Taichung 40447, Taiwan.; Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40447, Taiwan.; Drug Development Center, China Medical University, Taichung 40447, Taiwan.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2021 Sep 23; Vol. 22 (19). Date of Electronic Publication: 2021 Sep 23.