Visualization of Protein Sorting at the Trans-Golgi Network and Endosomes Through Super-Resolution Imaging

Autor: Yan Huang, Tianji Ma, Pik Ki Lau, Jinhui Wang, Teng Zhao, Shengwang Du, Michael M. T. Loy, Yusong Guo

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 7 (2019)

The trans-Golgi network (TGN) and endosomes are essential protein sorting stations in the secretory transport pathway. Protein sorting is fundamentally a process of spatial segregation, but the spatial relationships among the proteins that constitute

Externí odkaz: https://doaj.org/article/d526e8b2ceff4dfe85a6e0c762562b44

Plasma DNA Profile Associated with DNASE1L3 Gene Mutations: Clinical Observations, Relationships to Nuclease Substrate Preference, and In Vivo Correction

Autor: Vanja Sisirak, Lai-Shan Tam, Yueyang Wang, Wenlei Peng, Rossa W.K. Chiu, Lee Serpas, Alberto Magnasco, Pik Ki Lau, K.C. Allen Chan, Y.M. Dennis Lo, Wing-Shan Lee, Elisa Buti, Rebecca W.Y. Chan, Meng Ni, Diana S.C. Han, Priscilla Wong, Peiyong Jiang, Boris Reizis, Nora AlMutairi, Lydia Ho-Pui Tam, Ali Rashidfarrokhi, Alice S.H. Cheng, Patty P.P. Tse, Linda T. Hiraki, Stefano Volpi

Publikováno v: American Journal of Human Genetics
American Journal of Human Genetics, Elsevier (Cell Press), 2020, 107, pp.882-894. ⟨10.1016/j.ajhg.2020.09.006⟩

International audience; Plasma DNA fragmentomics is an emerging area in cell-free DNA diagnostics and research. In murine models, it has been shown that the extracellular DNase, DNASE1L3, plays a role in the fragmentation of plasma DNA. In humans, DN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abbc1cc1f3e00c981960db4b019a6c8e
http://hdl.handle.net/11567/1034759

A mechanism for differential sorting of the planar cell polarity proteins Frizzled6 and Vangl2 at the trans-Golgi network

Autor: Liwen Jiang, Yusong Guo, Randy Schekman, Baiying Li, Pik Ki Lau, Ryan Wang, Tianji Ma, Yan Huang

Publikováno v: The Journal of biological chemistry, vol 293, iss 22

In planar cell polarity (PCP), the epithelial cells are polarized along the plane of the cell surface perpendicular to the classical apical–basal axis, a process mediated by several conserved signaling receptors. Two PCP-signaling proteins, VANGL p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb1708f1e4f9b162d5e0fde93a52d16f
https://escholarship.org/uc/item/80d7t5qc

The exocyst functions in niche cells to promote germline stem cell differentiation by directly controlling EGFR membrane trafficking.

Autor: Ying Mao, Renjun Tu, Yan Huang, Decai Mao, Zhihao Yang, Pik Ki Lau, Jinhui Wang, Jianquan Ni, Yusong Guo, Ting Xie

Publikováno v: Development (09501991); Jul2019, Vol. 146 Issue 13, p1-14, 14p