Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Pik Fang Kho"'
Autor:
Ming-Li Chen, Pik Fang Kho, Rodrigo Guarischi-Sousa, Jiayan Zhou, Daniel J. Panyard, Zahra Azizi, Trisha Gupte, Kathleen Watson, Fahim Abbasi, Themistocles L. Assimes
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
Background and aimsUltrasound derived carotid intima-media thickness (cIMT) is valuable for cardiovascular risk stratification. We assessed the relative importance of traditional atherosclerosis risk factors and plasma proteins in predicting cIMT mea
Externí odkaz:
https://doaj.org/article/bbe1f1e3085a4344af2a484b29445acd
Autor:
Xuemin Wang, Pik Fang Kho, Dhanya Ramachandran, Cemsel Bafligil, Frederic Amant, Ellen L. Goode, Rodney J. Scott, Ian Tomlinson, D. Gareth Evans, Emma J. Crosbie, Thilo Dörk, Amanda B. Spurdle, Dylan M. Glubb, Tracy A. O'Mara
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106590- (2023)
Summary: To detect novel endometrial cancer risk variants, we leveraged information from endometrial cancer risk factors in a multi-trait GWAS analysis. We first assessed causal relationships between established and suspected endometrial cancer risk
Externí odkaz:
https://doaj.org/article/8dd1483258de40008b74d4a653bb1ccc
Autor:
Pik Fang Kho, Xuemin Wang, Gabriel Cuéllar-Partida, Thilo Dörk, Ellen L. Goode, Diether Lambrechts, Rodney J. Scott, Amanda B. Spurdle, Tracy A. O’Mara, Dylan M. Glubb
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-8 (2021)
Pik Fang Kho et al. conduct multi-tissue transcriptome-wide association studies of endometrial cancer risk. Their results identify potential susceptibility genes for endometrial cancer, and provide avenues for the development of future treatments for
Externí odkaz:
https://doaj.org/article/f859394cfae2471b93003faa05b0e90d
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Endometrial cancer is the most commonly diagnosed gynecological cancer in developed countries. Based on evidence from observational studies which suggest selenium inhibits the development of several cancers (including lung and prostate cancer), selen
Externí odkaz:
https://doaj.org/article/b27f7390809a41bdb55e48bc0571bc90
Publikováno v:
Twin Research and Human Genetics. 25:180-186
Colorectal cancer is the third most common and second most deadly type of cancer worldwide, with approximately 1.9 million cases and 0.9 million deaths worldwide in 2020. Previous studies have shown that estrogen and testosterone hormones are associa
Autor:
Scott F. Farrell, Michele Sterling, David M. Klyne, Sanam Mustafa, Adrián I. Campos, Pik-Fang Kho, Mischa Lundberg, Miguel E. Rentería, Trung Thanh Ngo, Gabriel Cuéllar-Partida
Publikováno v:
European Spine Journal.
Purpose Causal mechanisms underlying systemic inflammation in spinal & widespread pain remain an intractable experimental challenge. Here we examined whether: (i) associations between blood C-reactive protein (CRP) and chronic back, neck/shoulder & w
Autor:
Corinne Carland, Grace Png, Anders Malarstig, Pik Fang Kho, Stefan Gustafsson, Karl Michaelsson, Lars Lind, Emmanouil Tsafantakis, Maria Karaleftheri, George Dedoussis, Anna Ramisch, Erin Macdonald-Dunlop, Lucija Klaric, Peter K. Joshi, Yan Chen, Hanna M. Björck, Per Eriksson, Julia Carrasco-Zanini, Eleanor Wheeler, Karsten Suhre, Arthur Gilly, Eleftheria Zeggini, Ana Viñuela, Emmanouil T. Dermitzakis, James F. Wilson, Claudia Langenberg, Gaurav Thareja, Anna Halama, Frank Schmidt, SCALLOP Consortium, Daniela Zanetti, Themistocles Assimes
Background: Human plasma contains a wide variety of circulating proteins. These proteins can be important clinical biomarkers in disease and also possible drug targets. Large scale genomics studies of circulating proteins can identify genetic variant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4644e1f69a824ecf58f602bffea2d832
https://doi.org/10.21203/rs.3.rs-2621829/v1
https://doi.org/10.21203/rs.3.rs-2621829/v1
Autor:
Adrian I, Campos, Nathan, Ingold, Yunru, Huang, Brittany L, Mitchell, Pik-Fang, Kho, Xikun, Han, Luis M, García-Marín, Jue-Sheng, Ong, Matthew H, Law, Jennifer S, Yokoyama, Nicholas G, Martin, Xianjun, Dong, Gabriel, Cuellar-Partida, Stuart, MacGregor, Stella, Aslibekyan, Miguel E, Rentería
Publikováno v:
Sleep. 46
Study ObjectivesDespite its association with severe health conditions, the etiology of sleep apnea (SA) remains understudied. This study sought to identify genetic variants robustly associated with SA risk.MethodsWe performed a genome-wide associatio
Autor:
Pik Fang Kho, Luis M. García-Marín, Miguel E. Rentería, Gabriel Cuellar-Partida, Nicholas G. Martin, Adrian I. Campos
Publikováno v:
Human Genetics. 140:1253-1265
In the present study, we sought to identify causal relationships between obesity and other complex traits and conditions using a data-driven hypothesis-free approach that uses genetic data to infer causal associations. We leveraged available summary-
Autor:
Scott F. Farrell, Pik-Fang Kho, Mischa Lundberg, Adrián I. Campos, Miguel E. Rentería, Rutger M.J. de Zoete, Michele Sterling, Trung Thanh Ngo, Gabriel Cuéllar-Partida
The multiple comorbiditiesdimensions of chronic pain present a formidable challenge in disentangling its aetiology. Here, we performed genome-wide association studies of 8 chronic pain types using UK Biobank data (N =4,037-79,089 cases; N = 239,125 c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::339ee0b82863d280a939404e4e6880f1
https://doi.org/10.1101/2022.03.13.22272317
https://doi.org/10.1101/2022.03.13.22272317