Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Piia-Riitta Karhemo"'
Autor:
Henna Pehkonen, Artemis Filippou, Juho Väänänen, Iida Lindfors, Mira Vänttinen, Philipp Ianevski, Anne Mäkelä, Pauliina Munne, Juha Klefström, Sanna Toppila‐Salmi, Reidar Grénman, Jaana Hagström, Antti A. Mäkitie, Piia‐Riitta Karhemo, Outi Monni
Publikováno v:
Molecular Oncology, Vol 18, Iss 3, Pp 662-676 (2024)
PTPRF interacting protein alpha 1 (PPFIA1) encodes for liprin‐α1, a member of the leukocyte common antigen–related protein tyrosine phosphatase (LAR‐RPTPs)‐interacting protein family. Liprin‐α1 localizes to adhesive and invasive structure
Externí odkaz:
https://doaj.org/article/5adbbe91f802423398c274eb66b71c64
Autor:
Artemis Filippou, Henna Pehkonen, Piia-Riitta Karhemo, Juho Väänänen, Anni I. Nieminen, Juha Klefström, Reidar Grénman, Antti A. Mäkitie, Heikki Joensuu, Outi Monni
Publikováno v:
Cancers, Vol 13, Iss 5, p 1170 (2021)
Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous group of tumors that derive from the mucosal epithelium of the upper aerodigestive tract and present high mortality rate. Lack of efficient targeted-therapies and biomarkers towards pat
Externí odkaz:
https://doaj.org/article/6d0fcf088c224111a69fb308508676ba
Autor:
Katja Tuomainen, Ahmed Al-Samadi, Swapnil Potdar, Laura Turunen, Minna Turunen, Piia-Riitta Karhemo, Paula Bergman, Maija Risteli, Pirjo Åström, Riia Tiikkaja, Reidar Grenman, Krister Wennerberg, Outi Monni, Tuula Salo
Publikováno v:
Cancers, Vol 12, Iss 1, p 92 (2019)
In vitro cancer drug testing carries a low predictive value. We developed the human leiomyoma−derived matrix “Myogel” to better mimic the human tumor microenvironment (TME). We hypothesized that Myogel could provide an appropriate microenvironm
Externí odkaz:
https://doaj.org/article/37fde63d6ff048fca414703f91d6e98f
Autor:
Outi Monni, Heikki Joensuu, Krister Wennerberg, Tero Aittokallio, Olli Kallioniemi, Stina M. Syrjänen, Reidar Grénman, Harri Sihto, Mikko Kivento, Evgeny Kulesskiy, Astrid Murumägi, Bhagwan Yadav, Riku Louhimo, Piia-Riitta Karhemo, Tatiana Lepikhova
Table S1. Genes included in the targeted next-generation sequencing HNSCC gene panel. Table S2. Compounds (n=220) and their drug classes/targets used in the drug screen. Table S3. qPCR primers and qPCR vs GE_microarray correlation. Table S4. Drug sen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48ae8f8ec407eaf883076faa5c626fba
https://doi.org/10.1158/1535-7163.22505545
https://doi.org/10.1158/1535-7163.22505545
Autor:
Outi Monni, Heikki Joensuu, Krister Wennerberg, Tero Aittokallio, Olli Kallioniemi, Stina M. Syrjänen, Reidar Grénman, Harri Sihto, Mikko Kivento, Evgeny Kulesskiy, Astrid Murumägi, Bhagwan Yadav, Riku Louhimo, Piia-Riitta Karhemo, Tatiana Lepikhova
Figure S1. Heat map of drug responses of 220 compounds across 45 HPV negative cell lines. Figure S2. DSS scores and grouping of the used drugs based on their functional categories. Figure S3. An effect of transient knock-down of RAB25 and FAM83H to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d4763a3b0d3e785c0b4b02ef8ac8391
https://doi.org/10.1158/1535-7163.22505548
https://doi.org/10.1158/1535-7163.22505548
Autor:
Outi Monni, Heikki Joensuu, Krister Wennerberg, Tero Aittokallio, Olli Kallioniemi, Stina M. Syrjänen, Reidar Grénman, Harri Sihto, Mikko Kivento, Evgeny Kulesskiy, Astrid Murumägi, Bhagwan Yadav, Riku Louhimo, Piia-Riitta Karhemo, Tatiana Lepikhova
There is an unmet need for effective targeted therapies for patients with advanced head and neck squamous cell carcinoma (HNSCC). We correlated gene expression, gene copy numbers, and point mutations in 45 human papillomavirus–negative HNSCC cell l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2c1e24c64e9f023b80e41c77116c8b2
https://doi.org/10.1158/1535-7163.c.6538108.v1
https://doi.org/10.1158/1535-7163.c.6538108.v1
Autor:
Sanna Viitasalo, Piia-Riitta Karhemo, Juho Väänänen, Taru Ilmarinen, Markus Lilja, Riku Katainen, Outi Monni, Leena-Maija Aaltonen
We explored somatic mutations in dysplastic sinonasal inverted papilloma (SNIP), SNIP with concomitant sinonasal squamous cell carcinoma (SNSCC), and SNSCC without preceding SNIP. Ten SNIP and SNSCC samples were analyzed with exome sequencing and tes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::607d5c72e92ae2d7947e5bfe437c6757
http://hdl.handle.net/10138/352270
http://hdl.handle.net/10138/352270
Autor:
Outi Monni, Maija Risteli, Tuula Salo, Riia Tiikkaja, Katja Tuomainen, Paula Bergman, Piia-Riitta Karhemo, Pirjo Åström, Swapnil Potdar, Ahmed Al-Samadi, Laura Turunen, Krister Wennerberg, Reidar Grénman, Minna Turunen
Publikováno v:
Cancers
Volume 12
Issue 1
Tuomainen, K, Al-samadi, A, Potdar, S, Turunen, L, Turunen, M, Karhemo, P, Bergman, P, Risteli, M, Åström, P, Tiikkaja, R, Grenman, R, Wennerberg, K, Monni, O & Salo, T 2020, ' Human Tumor–Derived Matrix Improves the Predictability of Head and Neck Cancer Drug Testing ', Cancers, vol. 12, no. 1, 92 . https://doi.org/10.3390/cancers12010092
Cancers, Vol 12, Iss 1, p 92 (2019)
Volume 12
Issue 1
Tuomainen, K, Al-samadi, A, Potdar, S, Turunen, L, Turunen, M, Karhemo, P, Bergman, P, Risteli, M, Åström, P, Tiikkaja, R, Grenman, R, Wennerberg, K, Monni, O & Salo, T 2020, ' Human Tumor–Derived Matrix Improves the Predictability of Head and Neck Cancer Drug Testing ', Cancers, vol. 12, no. 1, 92 . https://doi.org/10.3390/cancers12010092
Cancers, Vol 12, Iss 1, p 92 (2019)
In vitro cancer drug testing carries a low predictive value. We developed the human leiomyoma&ndash
derived matrix &ldquo
Myogel&rdquo
to better mimic the human tumor microenvironment (TME). We hypothesized that Myogel could provide an
derived matrix &ldquo
Myogel&rdquo
to better mimic the human tumor microenvironment (TME). We hypothesized that Myogel could provide an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6771bd83be52e40a2938c9838ea7b0f0
http://hdl.handle.net/10138/314700
http://hdl.handle.net/10138/314700
Autor:
Bhagwan Yadav, Riku Louhimo, Tatiana Lepikhova, Piia-Riitta Karhemo, Outi Monni, Heikki Joensuu, Reidar Grénman, Olli Kallioniemi, Mikko Kivento, Stina Syrjänen, Krister Wennerberg, Astrid Murumägi, Evgeny Kulesskiy, Tero Aittokallio, Harri Sihto
Publikováno v:
Molecular cancer therapeutics. 17(9)
There is an unmet need for effective targeted therapies for patients with advanced head and neck squamous cell carcinoma (HNSCC). We correlated gene expression, gene copy numbers, and point mutations in 45 human papillomavirus–negative HNSCC cell l
Autor:
Sakhr Al-kubati, Tuula Salo, Katja Tuomainen, Outi Monni, Piia-Riitta Karhemo, Swapnil Potdar, Ahmed Al-Samadi, Laura Turunen
Publikováno v:
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 128:e48
Objectives Oral squamous cell carcinoma (OSCC) is the sixth most common cancer worldwide. Traditionally, cancer cell lines cultured in 2D are used to predict the efficacy of new anti-cancer compounds. However, this method has low predicting value for