Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Piia Vehviläinen"'
Autor:
Merja Jaronen, Tarja Malm, Jari Koistinaho, Piia Valonen, Gundars Goldsteins, Eveliina Pollari, Piia Vehviläinen, Velta Keksa-Goldsteine
Publikováno v:
Human Molecular Genetics. 22:646-655
Protein disulfide isomerase (PDI) is an oxidoreductase assisting oxidative protein folding in the endoplasmic reticulum of all types of cells, including neurons and glia. In neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS), up
Autor:
Merja Lakso, Garry Wong, Martina Rudgalvyte, Merja Jaronen, Jari Koistinaho, Velta Keksa-Goldsteine, Michael J. Courtney, Šárka Lehtonen, Piia Vehviläinen, Gundars Goldsteins
Publikováno v:
Antioxidantsredox signaling. 25(8)
Protein misfolding occurs in neurodegenerative diseases, including Parkinson's disease (PD). In endoplasmic reticulum (ER), an overload of misfolded proteins, particularly alpha-synuclein (αSyn) in PD, may cause stress and activate the unfolded prot
Publikováno v:
Journal of Cellular Physiology. 221:586-593
The components of the extracellular matrix (ECM) and their differential expression patterns play important roles in tissue formation. The deposition of latent TGF-beta binding proteins (LTBPs) to the ECM exhibit distinct distribution profiles. We hav
Autor:
Juha Jäälinoja, Varpu Marjomäki, David E. Birk, Liisa Nissinen, Jyrki Heino, Mira Tulla, Leena Ala-Kokko, Petri Nykvist, Tiina Viitasalo, Joni Ylostalo, Richard W. Farndale, Jarmo Käpylä, Anna-Marja Säämänen, Piia Vehviläinen
Publikováno v:
Journal of Biological Chemistry. 279:51677-51687
Collagen IX is the prototype fibril-associated collagen with interruptions in triple helix. In human cartilage it covers collagen fibrils, but its putative cellular receptors have been unknown. The reverse transcription-PCR analysis of human fetal ti
Publikováno v:
Journal of Biological Chemistry. 278:24705-24713
Of the four latent transforming growth factor (TGF)-beta-binding proteins (LTBPs), LTBP-2 is different in the respect that it does not bind small latent forms of TGF-beta. LTBP-2 is therefore likely to have other roles in the extracellular matrix. LT
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 8 (2014)
Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience
In amyotrophic lateral sclerosis (ALS), mitochondrial dysfunction is recognized as one of the key elements contributing to the pathology. Mitochondria are the major source of intracellular reactive oxygen species (ROS). Increased production of ROS as
Autor:
Pamela Lindholm, Katri Koli, Marjukka Myllärniemi, Vuokko L. Kinnula, Jorma Keski-Oja, Ylermi Soini, Kaisa Salmenkivi, Piia Vehviläinen
Publikováno v:
Human pathology. 42(2)
Malignant mesothelioma is an aggressive cancer of the pleura with poor prognosis. There is a need to identify new biomarkers and therapeutic targets for this invasive and fatal disease. Transforming growth factor β (TGF-β) can promote mesothelioma
Publikováno v:
Experimental cell research. 314(13)
Targeting of transforming growth factor beta (TGF-beta) to the extracellular matrix (ECM) by latent TGF-beta binding proteins (LTBPs) regulates the availability of TGF-beta for interactions with endothelial cells during their quiescence and activatio
Publikováno v:
Antioxidantsredox signaling. 3(1)
Changes occur in gene expression during aging in vivo and in replicative senescence in vitro, suggesting that aging can affect gene regulation. We have recently observed age-related changes in ubiquitously expressed, oxidative stress-responsive nucle
Publikováno v:
Drugs in R&D
Parsons, R 2016, ' Comment on : “Cytotoxicity of Oxycodone and Morphine in Human Neuroblastoma and Mouse Motoneuronal Cells: A Comparative Approach” ', Drugs In R&D, pp. 1-2 . https://doi.org/10.1007/s40268-016-0135-y
Parsons, R 2016, ' Comment on : “Cytotoxicity of Oxycodone and Morphine in Human Neuroblastoma and Mouse Motoneuronal Cells: A Comparative Approach” ', Drugs In R&D, pp. 1-2 . https://doi.org/10.1007/s40268-016-0135-y
Article
Background and Objectives Oxycodone is the mo st commonly used opioid for the treatment of moderate to severe pain. The peak cerebrospinal fluid concentration after epidural oxycodone was reported to be 300-fold greater (0.025 mM) than w
Background and Objectives Oxycodone is the mo st commonly used opioid for the treatment of moderate to severe pain. The peak cerebrospinal fluid concentration after epidural oxycodone was reported to be 300-fold greater (0.025 mM) than w