Temporally and spatially regulated collagen XVIII isoforms are involved in ureteric tree development via the TSP1-like domain

Autor: Rinta-Jaskari, M. M. (Mia M.), Naillat, F. (Florence), Ruotsalainen, H. J. (Heli J.), Koivunen, J. T. (Jarkko T.), Sasaki, T. (Takako), Pietilä, I. (Ilkka), Elamaa, H. P. (Harri P.), Kaur, I. (Inderjeet), Manninen, A. (Aki), Vainio, S. J. (Seppo J.), Pihlajaniemi, T. A. (Taina A.)

Collagen XVIII (ColXVIII) is a component of the extracellular matrix implicated in embryogenesis and control of tissue homoeostasis. We now provide evidence that ColXVIII has a specific role in renal branching morphogenesis as observed in analyses of

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http://urn.fi/urn:nbn:fi-fe2023032132721

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The CMS19 disease model specifies a pivotal role for collagen XIII in bone homeostasis

Autor: Kemppainen, A. V. (A. V.), Finnilä, M. A. (M. A.), Heikkinen, A. (A.), Härönen, H. (H.), Izzi, V. (V.), Kauppinen, S. (S.), Saarakkala, S. (S.), Pihlajaniemi, T. (T.), Koivunen, J. (J.)

Mutations in the COL13A1 gene result in congenital myasthenic syndrome type 19 (CMS19), a disease of neuromuscular synapses and including various skeletal manifestations, particularly facial dysmorphisms. The phenotypic consequences in Col13a1 null m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2423::5d6ebc49adf877fe06248504d428d6f6
http://urn.fi/urn:nbn:fi-fe2022102563245

Targeting collagen XVIII improves the efficiency of ErbB inhibitors in breast cancer models.

Autor: Devarajan R; Oulu Center for Cell-Matrix Research, Faculty of Biochemistry and Molecular Medicine.; Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit.; Biocenter Oulu, and., Izzi V; Oulu Center for Cell-Matrix Research, Faculty of Biochemistry and Molecular Medicine.; Research Unit of Biomedicine, University of Oulu, Oulu, Finland.; Finnish Cancer Research Institute, Helsinki, Finland., Peltoketo H; Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit.; Biocenter Oulu, and., Rask G; Department of Medical Biosciences/Pathology, Umeå University, Umeå, Sweden., Kauppila S; Department of Pathology, Oulu University Hospital and University of Oulu, Oulu, Finland.; Northern Finland Laboratory Centre, NordLab, Oulu, Finland., Väisänen MR; Department of Pathology, Kainuu Central Hospital, Kajaani, Finland., Ruotsalainen H; Oulu Center for Cell-Matrix Research, Faculty of Biochemistry and Molecular Medicine., Martínez-Nieto G; Oulu Center for Cell-Matrix Research, Faculty of Biochemistry and Molecular Medicine., Karppinen SM; Oulu Center for Cell-Matrix Research, Faculty of Biochemistry and Molecular Medicine., Väisänen T; Department of Pathology, Oulu University Hospital and University of Oulu, Oulu, Finland., Kaur I; Oulu Center for Cell-Matrix Research, Faculty of Biochemistry and Molecular Medicine., Koivunen J; Department of Medical Oncology and Radiotherapy and Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland., Sasaki T; Department of Pharmacology, Faculty of Medicine, Oita University, Oita, Japan., Winqvist R; Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit.; Biocenter Oulu, and.; Northern Finland Laboratory Centre, NordLab, Oulu, Finland., Manninen A; Disease Networks Research Unit, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland., Wärnberg F; Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden., Sund M; Department of Surgery and Perioperative Sciences/Surgery, Umeå University, Umeå, Sweden.; Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Pihlajaniemi T; Oulu Center for Cell-Matrix Research, Faculty of Biochemistry and Molecular Medicine., Heljasvaara R; Oulu Center for Cell-Matrix Research, Faculty of Biochemistry and Molecular Medicine.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2023 Sep 15; Vol. 133 (18). Date of Electronic Publication: 2023 Sep 15.

Lack of collagen XVIII leads to lipodystrophy and perturbs hepatic glucose and lipid homeostasis.

Autor: Petäistö T; Oulu Center for Cell-Matrix Research, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland., Vicente D; Oulu Center for Cell-Matrix Research, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland., Mäkelä KA; Research Unit of Biomedicine, Biocenter Oulu and Faculty of Medicine, University of Oulu, Oulu, Finland., Finnilä MA; Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland., Miinalainen I; Biocenter Oulu, University of Oulu, Oulu, Finland., Koivunen J; Oulu Center for Cell-Matrix Research, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland., Izzi V; Oulu Center for Cell-Matrix Research, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland., Aikio M; Oulu Center for Cell-Matrix Research, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland., Karppinen SM; Oulu Center for Cell-Matrix Research, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland., Devarajan R; Oulu Center for Cell-Matrix Research, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland., Thevenot J; Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland., Herzig KH; Research Unit of Biomedicine, Biocenter Oulu and Faculty of Medicine, University of Oulu, Oulu, Finland., Heljasvaara R; Oulu Center for Cell-Matrix Research, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.; Department of Biomedicine, Centre for Cancer Biomarkers (CCBIO), University of Bergen, Bergen, Norway., Pihlajaniemi T; Oulu Center for Cell-Matrix Research, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.

Publikováno v: The Journal of physiology [J Physiol] 2020 Aug; Vol. 598 (16), pp. 3373-3393. Date of Electronic Publication: 2020 Jun 15.