Zobrazeno 1 - 10
of 1 792
pro vyhledávání: '"PiggyBac"'
Autor:
Masahiro Tanaka, Yoshihiro Iwamoto, Bo Wang, Eri Imai, Munehiro Yoshida, Shoichi Iriguchi, Shin Kaneko
Publikováno v:
Regenerative Therapy, Vol 27, Iss , Pp 104-111 (2024)
Introduction: Genetically modified human induced pluripotent stem cell (iPSC)-based regenerative medicine has substantial potential in the treatment of refractory human diseases. Thus, preclinical studies on the safety and efficacy of these products
Externí odkaz:
https://doaj.org/article/1ddaf5267efa4756bc597686a33ece9a
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/3af9177edf0242ab84acd41478fdde4d
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundThe non-viral production of CAR-T cells through electroporation of transposon DNA plasmids is an alternative approach to lentiviral/retroviral methods. This method is particularly suitable for early-phase clinical trials involving novel typ
Externí odkaz:
https://doaj.org/article/77316501f7f440178ac5bdacf779f123
Autor:
Kento Morimoto, Hayate Suzuki, Akihiro Kuno, Yoko Daitoku, Yoko Tanimoto, Kanako Kato, Kazuya Murata, Fumihiro Sugiyama, Seiya Mizuno
Publikováno v:
Open Biology, Vol 14, Iss 4 (2024)
Functional regions that regulate biological phenomena are interspersed throughout eukaryotic genomes. The most definitive approach for identifying such regions is to confirm the phenotype of cells or organisms in which specific regions have been muta
Externí odkaz:
https://doaj.org/article/45cd721f7963429daf872c1a56ec5bfc
Autor:
Ming Liu, Linlin Zhang, Mingtian Zhong, Yihao Long, Wenhui Yang, Ting Liu, Xingxu Huang, Xiaodong Ma
Publikováno v:
Experimental Hematology & Oncology, Vol 12, Iss 1, Pp 1-5 (2023)
Abstract CAR T cell therapy has been successfully used in the treatment of hematological malignancies, and the strategy that deletion of inhibitory receptor on the CAR T cell surface, such as PD-1, greatly enhance the antitumor effects. Here, we desc
Externí odkaz:
https://doaj.org/article/37f639e56a5e468a964cca835dbf34f1
Publikováno v:
International Journal of Translational Medicine, Vol 3, Iss 3, Pp 374-388 (2023)
Type 1 Diabetes (T1D) is a chronic metabolic disorder for which current treatments are unable to prevent the onset of complications. Previously, we used an adeno-associated viral vector (AAV8) to deliver furin-cleavable human insulin (INS-FUR) to the
Externí odkaz:
https://doaj.org/article/a61c1240d3e442af9001404749933bba
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Extensive research has been conducted on utilizing transgenic silkworms and their natural spinning apparatus to produce high-performance spider silk fibers. However, research on using non-spider biological proteins to optimize the molecular structure
Externí odkaz:
https://doaj.org/article/ded19b8f479f484986f37efdb566f4ae
Autor:
Gergely Imre, Bertalan Takács, Erik Czipa, Andrea Bakné Drubi, Gábor Jaksa, Dóra Latinovics, Andrea Nagy, Réka Karkas, Liza Hudoba, Bálint Márk Vásárhelyi, Gabriella Pankotai-Bodó, András Blastyák, Zoltán Hegedűs, Péter Germán, Balázs Bálint, Khaldoon Sadiq Ahmed Abdullah, Anna Georgina Kopasz, Anita Kovács, László G. Nagy, Farkas Sükösd, Lajos Pintér, Thomas Rülicke, Endre Barta, István Nagy, Lajos Haracska, Lajos Mátés
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 145-159 (2023)
DNA transposon-based gene delivery vectors represent a promising new branch of randomly integrating vector development for gene therapy. For the side-by-side evaluation of the piggyBac and Sleeping Beauty systems—the only DNA transposons currently
Externí odkaz:
https://doaj.org/article/11d546c2a6444753ab7f307b4cde6bdd
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Thanyavi Chinsuwan, Koichi Hirabayashi, Shuji Mishima, Aiko Hasegawa, Miyuki Tanaka, Hidemi Mochizuki, Akihito Shimoi, Takashi Murakami, Shigeki Yagyu, Kimihiro Shimizu, Yozo Nakazawa
Publikováno v:
Molecular Therapy: Oncolytics, Vol 31, Iss , Pp 100728- (2023)
Epidermal growth factor receptor (EGFR) is overexpressed in various cancers, including non-small cell lung cancer (NSCLC), and in some somatic cells at a limited level, rendering it an attractive antitumor target. In this study, we engineered chimeri
Externí odkaz:
https://doaj.org/article/4fb11f3e6b7b4004996276229d6ffa87