Schwere Hyponatriämie nach Kombination von Oxytocin mit Desmopressin bei postpartaler Hämorrhagie. (German)

Autor: Brandt, C. M., Benner, A., Pietsch, L., Medl, M., Kunze, M., Kalbhenn, J.

Publikováno v: Anaesthesiologie & Intensivmedizin; jun2023, Vol. 64 Issue 6, p218-223, 6p

Demonstrating Ligandability of the LC3A and LC3B Adapter Interface

Autor: Hartmann, M., Huber, J., Kramer, J.S., Heering, J., Pietsch, L., Stark, H., Odadzic, D., Bischoff, I., Fürst, R., Schröder, M., Akutsu, M., Chaikuad, A., Dötsch, V., Knapp, S., Biondi, R.M., Rogov, V.V., Proschak, E.

Autophagy is the common name for a number of lysosome-based degradation pathways of cytosolic cargos. The key components of autophagy are members of Atg8 family proteins involved in almost all steps of the process, from autophagosome formation to the

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https://publica.fraunhofer.de/handle/publica/268858

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Crizotinib acts as ABL1 inhibitor combining ATP-binding with allosteric inhibition and is active against native BCR-ABL1 and its resistance and compound mutants BCR-ABL1 ^T315I and BCR-ABL1 ^T315I-E255K .

Autor: Mian AA; Department of Hematology, Division of Cancer and Genetics, and Experimental Clinical Medical Center (ECMC), Medical School, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK.; Center for Regenerative Medicine and Stem Cell Research, Aga Khan University, Karachi, Pakistan., Haberbosch I; Department of Internal Medicine II, Goethe University, Frankfurt, Germany., Khamaisie H; Department of Nutrition and Natural Products, Migal-Galilee Technology Center, PO Box 831, 11016, Kiryat Shmona, Israel., Agbarya A; Oncology Department, Bnai Zion MC, Haifa, Israel., Pietsch L; Department of Internal Medicine I, Clinic of Goethe University, Frankfurt, Germany.; German Cancer Consortium (DKTK), Frankfurt, Germany., Eshel E; Hematology Institute, Ziv Medical Center, Azrieli Faculty of Medicine, Bar Ilan University, Zfat, Israel., Najib D; Hematology Institute, Ziv Medical Center, Azrieli Faculty of Medicine, Bar Ilan University, Zfat, Israel., Chiriches C; Department of Hematology, Division of Cancer and Genetics, and Experimental Clinical Medical Center (ECMC), Medical School, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK., Ottmann OG; Department of Hematology, Division of Cancer and Genetics, and Experimental Clinical Medical Center (ECMC), Medical School, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK., Hantschel O; Swiss Institute for Experimental Cancer Research, School of Life Sciences, École polytechnique fédérale de Lausanne, Lausanne, Switzerland.; Medical Biochemistry and Pharmacology Center, Institute for Physiological Chemistry, Philipps-University, Marburg, Germany., Biondi RM; Department of Internal Medicine I, Clinic of Goethe University, Frankfurt, Germany.; German Cancer Consortium (DKTK), Frankfurt, Germany.; Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA)-CONICET-Partner Institute of the Max Planck Society, Buenos Aires, Argentina., Ruthardt M; Department of Hematology, Division of Cancer and Genetics, and Experimental Clinical Medical Center (ECMC), Medical School, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK. ruthardtm@cardiff.ac.uk., Mahajna J; Department of Nutrition and Natural Products, Migal-Galilee Technology Center, PO Box 831, 11016, Kiryat Shmona, Israel. jamalm@migal.org.il.; The Department of Nutritional Sciences, Tel Hai Academic College, Kiryat Shmona, Israel. jamalm@migal.org.il.

Publikováno v: Annals of hematology [Ann Hematol] 2021 Aug; Vol. 100 (8), pp. 2023-2029. Date of Electronic Publication: 2021 Jun 10.

Demonstrating Ligandability of the LC3A and LC3B Adapter Interface.

Autor: Hartmann M; Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt, Germany., Huber J; Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance Goethe-University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt, Germany., Kramer JS; Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt, Germany., Heering J; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Theodor-Stern-Kai 7, 60596 Frankfurt, Germany., Pietsch L; Department of Internal Medicine I, Goethe University Hospital Frankfurt, Theodor-Stern-Kai 7, 60596 Frankfurt, Germany., Stark H; German translational cancer network (DKTK), site Frankfurt/Mainz, 60438 Frankfurt, Germany.; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitaetsstr. 1, 40225 Duesseldorf, Germany., Odadzic D; German translational cancer network (DKTK), site Frankfurt/Mainz, 60438 Frankfurt, Germany., Bischoff I; Institute of Pharmaceutical Biology, Goethe-University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt, Germany., Fürst R; Institute of Pharmaceutical Biology, Goethe-University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt, Germany., Schröder M; Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt, Germany., Akutsu M; Buchmann Institute for Molecular Life Sciences, Goethe-University Frankfurt, Max-von-Laue-Str. 15, 60438 Frankfurt, Germany., Chaikuad A; Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt, Germany., Dötsch V; Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance Goethe-University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt, Germany., Knapp S; Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt, Germany.; German translational cancer network (DKTK), site Frankfurt/Mainz, 60438 Frankfurt, Germany., Biondi RM; Department of Internal Medicine I, Goethe University Hospital Frankfurt, Theodor-Stern-Kai 7, 60596 Frankfurt, Germany., Rogov VV; Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt, Germany.; Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance Goethe-University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt, Germany., Proschak E; Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Theodor-Stern-Kai 7, 60596 Frankfurt, Germany.; German translational cancer network (DKTK), site Frankfurt/Mainz, 60438 Frankfurt, Germany.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2021 Apr 08; Vol. 64 (7), pp. 3720-3746. Date of Electronic Publication: 2021 Mar 26.