Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Pietro Pichierri"'
Publikováno v:
eLife, Vol 12 (2024)
R-loops are non-canonical DNA structures that form during transcription and play diverse roles in various physiological processes. Disruption of R-loop homeostasis can lead to genomic instability and replication impairment, contributing to several hu
Externí odkaz:
https://doaj.org/article/b8e1699c4ee14225866a0af417da4a8f
Autor:
Eva Malacaria, Giusj Monia Pugliese, Masayoshi Honda, Veronica Marabitti, Francesca Antonella Aiello, Maria Spies, Annapaola Franchitto, Pietro Pichierri
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Stabilisation of stalled replication forks prevents excessive fork reversal and genome instability. Here authors reveal a RAD52-dependent replication fork protection mechanism.
Externí odkaz:
https://doaj.org/article/bedcee1b92964acbaf09d7d1347cc53c
Autor:
Veronica Marabitti, Pasquale Valenzisi, Giorgia Lillo, Eva Malacaria, Valentina Palermo, Pietro Pichierri, Annapaola Franchitto
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1547 (2022)
Maintenance of genome stability is crucial for cell survival and relies on accurate DNA replication. However, replication fork progression is under constant attack from different exogenous and endogenous factors that can give rise to replication stre
Externí odkaz:
https://doaj.org/article/3cce765f2af74f9690d7512038949d48
Autor:
Giusj Monia Pugliese, Federico Salaris, Valentina Palermo, Veronica Marabitti, Nicolò Morina, Alessandro Rosa, Annapaola Franchitto, Pietro Pichierri
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 10 (2019)
Schimke immuno-osseous dysplasia is an autosomal recessive genetic osteochondrodysplasia characterized by dysmorphism, spondyloepiphyseal dysplasia, nephrotic syndrome and frequently T cell immunodeficiency. Several hypotheses have been proposed to e
Externí odkaz:
https://doaj.org/article/68c1e899dfb5417e8d0ffdd51baae21f
Autor:
Dipon Das, Molly L. Bristol, Nathan W. Smith, Claire D. James, Xu Wang, Pietro Pichierri, Iain M. Morgan
Publikováno v:
mBio, Vol 10, Iss 4 (2019)
Externí odkaz:
https://doaj.org/article/bba799e30f464806835205675ecebb9e
Autor:
Dipon Das, Molly L. Bristol, Nathan W. Smith, Claire D. James, Xu Wang, Pietro Pichierri, Iain M. Morgan
Publikováno v:
mBio, Vol 10, Iss 2 (2019)
ABSTRACT Human papillomaviruses (HPV) are double-stranded DNA viruses causative in a host of human diseases, including several cancers. Following infection, two viral proteins, E1 and E2, activate viral replication in association with cellular factor
Externí odkaz:
https://doaj.org/article/88f167d3aab64039bfa284257fa9e8ca
Autor:
Valentina Palermo, Sara Rinalducci, Massimo Sanchez, Francesca Grillini, Joshua A. Sommers, Robert M. Brosh, Lello Zolla, Annapaola Franchitto, Pietro Pichierri
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
End-resection of double strand DNA breaks is essential for pathway choice between non-homologous end-joining and homologous recombination. Here the authors show that phosphorylation of WRN helicase by CDK1 is essential for resection at replication-re
Externí odkaz:
https://doaj.org/article/c5a07e25c5d84b82a2f6c7c01fa3ba7f
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 20, p 7564 (2020)
Human papillomaviruses have 8kbp DNA episomal genomes that replicate autonomously from host DNA. During initial infection, the virus increases its copy number to 20–50 copies per cell, causing torsional stress on the replicating DNA. This activates
Externí odkaz:
https://doaj.org/article/deeac4ed405f413b986e7a914304bfd7
Autor:
Giuseppe Cortone, Ge Zheng, Pasquale Pensieri, Viviana Chiappetta, Rosarita Tatè, Eva Malacaria, Pietro Pichierri, Hongtao Yu, Francesca M Pisani
Publikováno v:
PLoS Genetics, Vol 14, Iss 10, p e1007622 (2018)
Establishment of sister chromatid cohesion is coupled to DNA replication, but the underlying molecular mechanisms are incompletely understood. DDX11 (also named ChlR1) is a super-family 2 Fe-S cluster-containing DNA helicase implicated in Warsaw brea
Externí odkaz:
https://doaj.org/article/1f67aff65e4e476eaab083559b9c04bc
Autor:
Valentina Palermo, Sara Rinalducci, Massimo Sanchez, Francesca Grillini, Annapaola Franchitto, Pietro Pichierri
Publikováno v:
Molecular & Cellular Oncology, Vol 4, Iss 1 (2017)
Replication-dependent double-strand breaks (DSBs) are the main source of genomic instability as their inaccurate repair stimulates chromosomal rearrangements. In a recent work, we uncover a novel regulatory circuit that involves the Werner's syndrome
Externí odkaz:
https://doaj.org/article/0f55fabeadbc4644b55b9f1d2818ead9