Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Pietro Genovese"'
Autor:
Elisa Landoni, Mark G. Woodcock, Gabriel Barragan, Gabriele Casirati, Vincenzo Cinella, Simone Stucchi, Leah M. Flick, Tracy A. Withers, Hanna Hudson, Giulia Casorati, Paolo Dellabona, Pietro Genovese, Barbara Savoldo, Leonid S. Metelitsa, Gianpietro Dotti
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Human natural killer T cells (NKTs) are innate-like T lymphocytes increasingly used for cancer immunotherapy. Here we show that human NKTs expressing the pro-inflammatory cytokine interleukin-12 (IL-12) undergo extensive and sustained molecu
Externí odkaz:
https://doaj.org/article/a48e168e6afd41a0a78d021d474cf617
Autor:
Beatrice Claudia Cianciotti, Zulma Irene Magnani, Alessia Ugolini, Barbara Camisa, Ivan Merelli, Valentina Vavassori, Alessia Potenza, Antonio Imparato, Francesco Manfredi, Danilo Abbati, Laura Perani, Antonello Spinelli, Eric Shifrut, Fabio Ciceri, Luca Vago, Raffaella Di Micco, Luigi Naldini, Pietro Genovese, Eliana Ruggiero, Chiara Bonini
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundIn adoptive T cell therapy, the long term therapeutic benefits in patients treated with engineered tumor specific T cells are limited by the lack of long term persistence of the infused cellular products and by the immunosuppressive mechani
Externí odkaz:
https://doaj.org/article/0c75a1d1ee5c498d8c626e70eae69c03
Autor:
Elisa Landoni, Mark G. Woodcock, Gabriel Barragan, Gabriele Casirati, Vincenzo Cinella, Simone Stucchi, Leah M. Flick, Tracy A. Withers, Hanna Hudson, Giulia Casorati, Paolo Dellabona, Pietro Genovese, Barbara Savoldo, Leonid S. Metelitsa, Gianpietro Dotti
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/472487173e704ef3ad30fb9dddbe2c08
Autor:
Jing Zeng, Jerome Ritz, Gabriele Casirati, Andrea Cosentino, Adele Mucci, Mohammed S Mahmoud, Iratxe Ugarte Zabala, Denise Klatt, Christian Brendel, Scott Ficarro, Jarrod Marto, Danilo Pellin, Daniel Bauer, Scott A Armstrong, Pietro Genovese
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/83551a902d254e8c92d56c160fced919
Autor:
Claudio Costantino, Livia Cimino, Nicole Bonaccorso, Arianna Conforto, Martina Sciortino, Francesco Blangiardi, Girolama Bosco, Gaspare Canzoneri, Nicolò Casuccio, Calogero Collura, Mario Cuccia, Roberto Furnari, Pietro Genovese, Giovanni Gucciardi, Maria Angela Randazzo, Gino Enzo Taranto, Mario Palermo, Francesco Vitale
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 18, Iss 6 (2022)
Hexavalent (HV) vaccination is a priority for newborn protection and in Italy is included in the National Immunization Plan with a three doses cycle at 61, 121 and 301 days of age. A retrospective clinical study has been conducted to evaluate real li
Externí odkaz:
https://doaj.org/article/33eab6fd4a744261ace023847fcc1f0a
Publikováno v:
Frontiers in Genome Editing, Vol 3 (2021)
Externí odkaz:
https://doaj.org/article/529c747a7b16481cb2c83de066cc079c
Autor:
Samuele Ferrari, Valentina Vavassori, Daniele Canarutto, Aurelien Jacob, Maria Carmina Castiello, Attya Omer Javed, Pietro Genovese
Publikováno v:
Frontiers in Genome Editing, Vol 3 (2021)
In the field of hematology, gene therapies based on integrating vectors have reached outstanding results for a number of human diseases. With the advent of novel programmable nucleases, such as CRISPR/Cas9, it has been possible to expand the applicat
Externí odkaz:
https://doaj.org/article/b32545ce26e24840b29d5b4f310a9104
Autor:
Valentina Vavassori, Elisabetta Mercuri, Genni E Marcovecchio, Maria C Castiello, Giulia Schiroli, Luisa Albano, Carrie Margulies, Frank Buquicchio, Elena Fontana, Stefano Beretta, Ivan Merelli, Andrea Cappelleri, Paola MV Rancoita, Vassilios Lougaris, Alessandro Plebani, Maria Kanariou, Arjan Lankester, Francesca Ferrua, Eugenio Scanziani, Cecilia Cotta‐Ramusino, Anna Villa, Luigi Naldini, Pietro Genovese
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 3, Pp n/a-n/a (2021)
Abstract Precise correction of the CD40LG gene in T cells and hematopoietic stem/progenitor cells (HSPC) holds promise for treating X‐linked hyper‐IgM Syndrome (HIGM1), but its actual therapeutic potential remains elusive. Here, we developed a on
Externí odkaz:
https://doaj.org/article/9aef4eba41804327af789ffa8b24647a
Autor:
Paula Rio, Rocio Baños, Angelo Lombardo, Oscar Quintana‐Bustamante, Lara Alvarez, Zita Garate, Pietro Genovese, Elena Almarza, Antonio Valeri, Begoña Díez, Susana Navarro, Yaima Torres, Juan P Trujillo, Rodolfo Murillas, Jose C Segovia, Enrique Samper, Jordi Surralles, Philip D Gregory, Michael C Holmes, Luigi Naldini, Juan A Bueren
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 6, Pp 835-848 (2014)
Abstract Gene targeting is progressively becoming a realistic therapeutic alternative in clinics. It is unknown, however, whether this technology will be suitable for the treatment of DNA repair deficiency syndromes such as Fanconi anemia (FA), with
Externí odkaz:
https://doaj.org/article/9ea6a100ad2d43d6af6bfa973b399ceb
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2606
Base editing by nucleotide deaminases linked to programmable DNA-binding proteins represents a promising approach to remedy blood disorders. Here we describe the ex vivo base editing of human CD34+ hematopoietic stem and progenitor cells (HSPCs) by e