Výsledky vyhledávání - "Pietro G. Andres"

CD28 Signals in the Immature Immunological Synapse

Autor: Abul K. Abbas, Douglas Dresnek, Matthew F. Krummel, Kimberly C. Howland, Samuel Edmondson, Pietro G. Andres

Publikováno v: The Journal of Immunology. 172:5880-5886

T cell recognition of peptide-MHC complexes on APCs results in the aggregation of TCRs at a central supramolecular activation complex (c-SMAC) within a mature immunological synapse. T cells require a second “costimulatory” signal for activation,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d84ee7d8e5ddba48c81cc0be9aa1cc4
https://doi.org/10.4049/jimmunol.172.10.5880

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Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-γ but not TH2 cytokines

Autor: Lawrence P. Kane, Kimberly C. Howland, Arthur Weiss, Abul K. Abbas, Pietro G. Andres

Publikováno v: Nature Immunology. 2:37-44

A region of the interleukin-2 (IL-2) promoter known as the RE/AP element is activated in concert by signals that originate from the T cell antigen receptor and the CD28 coreceptor. We show here that the serine-threonine kinase Akt can provide a costi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22134525811430ab95e6f10606f6586a
https://doi.org/10.1038/83144

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NF-κB-Inducing Kinase Is a Common Mediator of IL-17-, TNF-α-, and IL-1β-Induced Chemokine Promoter Activation in Intestinal Epithelial Cells

Autor: Masaaki Awane, Pietro G. Andres, Dan Jun Li, Hans-Christian Reinecker

Publikováno v: The Journal of Immunology. 162:5337-5344

IL-17 expression is restricted to activated T cells, whereas the IL-17R is expressed in a variety of cell types including intestinal epithelial cells. However, the functional responses of intestinal epithelial cells to stimulation with IL-17 are unkn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d7763cf2d22c918fdfebab5c92c372e
https://doi.org/10.4049/jimmunol.162.9.5337

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Enhanced contact hypersensitivity and antiviral immune responses in vivo by keratinocyte-targeted overexpression of IL-15

Autor: Hans Christian Reinecker, Karin Loser, Sonja Ständer, Bodo R. Eing, Pietro G. Andres, Annette Mehling, Jenny Apelt, Stefan Beissert, Thomas Schwarz, Boris V. Skryabin, Georg Varga

Publikováno v: European journal of immunology. 34(7)

IL-15 is involved in lymphocyte homeostasis. To investigate the role of IL-15 in the skin in vivo, mice were generated that overexpress IL-15 in keratinocytes, resulting in increased IL-15 protein levels in the skin but not elevated IL-15 serum conce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::988bbb6f9047ed584d85016aea4798df
https://pubmed.ncbi.nlm.nih.gov/15214050

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New views of the immunological synapse: variations in assembly and function

Autor: Jordan Jacobelli, Pietro G. Andres, Judie Boisvert, Matthew F. Krummel

Publikováno v: Current opinion in immunology. 16(3)

The interaction of T cells with antigen-presenting cells results in the formation of a contact face, termed the immunological synapse. The prototypical dynamics of this process are well established and involve cessation of crawling, a highly fluid 'i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce443c201d0748b416bc09086ab74379
https://pubmed.ncbi.nlm.nih.gov/15134784

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Distinct regions in the CD28 cytoplasmic domain are required for T helper type 2 differentiation

Autor: Luke Barron, Pietro G. Andres, Ajay Nirula, Ali Sadra, Abul K. Abbas, Kimberly C. Howland, Lawrence P. Kane, Arthur Weiss, Douglas Dresnek, John B. Imboden

Publikováno v: Nature immunology. 5(4)

CD28 costimulation is essential for CD4(+) T cell proliferation, survival, interleukin 2 (IL-2) production and T helper type 2 development. To define the nature of the signals that may drive different T cell responses, we have done a structure-functi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82c9862176ad0165b63bbbfd4ee64ad6
https://pubmed.ncbi.nlm.nih.gov/15004555

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Expression of bcl-X(L) restores cell survival, but not proliferation off effector differentiation, in CD28-deficient T lymphocytes

Autor: Michael P. Lodge, Abul K. Abbas, A. Maria Dahl, Pietro G. Andres, Cheryl A. London, Christoph Klein, Richard C. Mulligan

Publikováno v: The Journal of Experimental Medicine

Lymphocytes deficient in the T cell costimulatory molecule CD28 exhibit defects in cell survival, clonal expansion, and differentiation into effector cells. It is known that CD28-mediated signaling results in the upregulation of the Bcl family member

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a7f7c800c66609fdb1e31473a2d60ba
https://pubmed.ncbi.nlm.nih.gov/10859328

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Mice with a selective deletion of the CC chemokine receptors 5 or 2 are protected from dextran sodium sulfate-mediated colitis: lack of CC chemokine receptor 5 expression results in a NK1.1+ lymphocyte-associated Th2-type immune response in the intestine

Autor: Daniel K. Podolsky, Tracey C. Dawson, Pietro G. Andres, Emiko Mizoguchi, William A. Kuziel, Atsushi Mizoguchi, Nobuyo Maeda, Richard P. MacDermott, Atul K. Bhan, Paul L. Beck, Hans Christian Reinecker

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 164(12)

The chemokine receptors CCR2 and CCR5 and their respective ligands regulate leukocyte chemotaxis and activation. To determine the role of these chemokine receptors in the regulation of the intestinal immune response, we induced colitis in CCR2- and C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c00bb49c337289a556332ec8ac15e5
https://pubmed.ncbi.nlm.nih.gov/10843684

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