Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Pietro Forte"'
Autor:
Guido Grandi, Immaculada Margarit, Emiliano Chiarot, Fabio Rigat, Karen S. Slobod, Frederick Wittke, Scott A. Halperin, Monica Fabbrini, Giovanna Tuscano, Elisabetta Frigimelica, Pietro Forte, Gilbert G.G. Donders, Sara Filippini, Roland Devlieger
Publikováno v:
The journal of infection
Objectives: The main aim of this exploratory study was to evaluate functional activity of antibodies elicited by a maternal Group B Streptococcus (GBS) investigational vaccine composed of capsular polysaccharides Ia, Ib, and III conjugated to genetic
Autor:
Sherryl Baker, Pietro Forte, Scott A. Halperin, Roland Devlieger, Karen S. Slobod, Gilbert G.G. Donders, Frederick Wittke, Peter M. Dull
Publikováno v:
Obstetrics and gynecology
OBJECTIVE:To evaluate the safety and immunogenicity of an investigational trivalent group B streptococcal vaccine in pregnant women and antibody transfer to their newborns.METHODS:The primary outcome of this observer-blind, randomized study was to es
Publikováno v:
The Journal of Immunology. 175:5463-5470
Pig-to-human xenotransplantation has been proposed as a means to alleviate the shortage of human organs for transplantation, but cellular rejection remains a hurdle for successful xenograft survival. NK cells have been implicated in xenograft rejecti
Autor:
Robert J. Hawley, Mårten K J Schneider, Jorg Dieter Seebach, Pietro Forte, Bettina C. Baumann, Robert Rieben
Publikováno v:
The Journal of Immunology. 172:6460-6467
The galactose-α-1,3-galactose (αGal) carbohydrate epitope is expressed on porcine, but not human cells, and therefore represents a major target for preformed human anti-pig natural Abs (NAb). Based on results from pig-to-primate animal models, NAb
Autor:
Pietro Forte, Jorg Dieter Seebach, Peter Groscurth, Luis Filgueira, Ulrike B. Matter-Reissmann, Mårten K J Schneider
Publikováno v:
Xenotransplantation. 9:325-337
Because of organ shortages in clinical allotransplantation, the potential of pig-to-human xenotransplantation is currently being explored showing a possible critical role for natural killer (NK) cells in the immune response against xenografts. Theref
Autor:
Pietro Forte, Laszlo Pazmany, Ulrike B. Matter-Reissmann, Jorg Dieter Seebach, Georg Stussi, Mårten K J Schneider
Publikováno v:
The Journal of Immunology. 167:6002-6008
Human NK cells adhere to and lyse porcine endothelial cells (pEC) and therefore may contribute to the cell-mediated rejection of vascularized pig-to-human xenografts. Since MHC class I molecules inhibit the cytotoxic activity of NK cells, the express
Publikováno v:
Scandinavian Journal of Immunology. 54:70-75
Human natural killer (NK) cells are able to adhere to xenogeneic porcine endothelial cells (EC) and evidence from in vitro studies as well as animal models suggests a potential role for NK cells in the cellular recognition and damage of porcine xenog
Autor:
Jorg Dieter Seebach, Marion Strasser, Ulrike B. Matter-Reissmann, Mårten K J Schneider, Pietro Forte
Publikováno v:
Human Immunology. 61:1066-1073
In this study we tested whether the expression of HLA-G protects porcine endothelial cells (PEC) from the lysis mediated by human natural killer (NK) cells. Because HLA-E is not present in PEC, this model provides an ideal tool to study the direct ro
Autor:
Peter M. Dull, Pietro Forte, Karen S. Slobod, Gilbert G.G. Donders, Sherryl Baker, Scott A. Halperin, Frederick Wittke, Roland Devlieger
Publikováno v:
Open Forum Infectious Diseases
Publikováno v:
Xenotransplantation, Vol. 16, No 1 (2009) pp. 19-26
BACKGROUND: Human natural killer (NK) cell-mediated cytotoxicity represents a hurdle in pig-to-human xenotransplantation. It was previously reported that the expression of human major histocompatibility complex class I molecules, including HLA-B27, -