Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Pietro, Mesirca"'
Autor:
Pietro Mesirca, Jean Chemin, Christian Barrère, Eleonora Torre, Laura Gallot, Arnaud Monteil, Isabelle Bidaud, Sylvie Diochot, Michel Lazdunski, Tuck Wah Soong, Stéphanie Barrère-Lemaire, Matteo E. Mangoni, Joël Nargeot
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract L-type voltage-gated calcium channels are involved in multiple physiological functions. Currently available antagonists do not discriminate between L-type channel isoforms. Importantly, no selective blocker is available to dissect the role o
Externí odkaz:
https://doaj.org/article/2ab832a282b64fedbaeb690c44acc317
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 6, p 3387 (2024)
Human-induced pluripotent stem cell (hiPSC)-derived cardiomyocytes raise the possibility of generating pluripotent stem cells from a wide range of human diseases. In the cardiology field, hiPSCs have been used to address the mechanistic bases of prim
Externí odkaz:
https://doaj.org/article/53e4e4fd00bb40e8acdd5391878146c2
Autor:
Mattia L. DiFrancesco, Manon Marrot, Eleonora Torre, Pietro Mesirca, Romain Davaze, Corinne Lautier, Pascaline Fontes, Joël Cuoq, Anne Fernandez, Ned Lamb, Fabien Pifferi, Nadine Mestre-Francés, Matteo E. Mangoni, Angelo G. Torrente
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Microcebus murinus, or gray mouse lemur (GML), is one of the smallest primates known, with a size in between mice and rats. The small size, genetic proximity to humans and prolonged senescence, make this lemur an emerging model for neurodege
Externí odkaz:
https://doaj.org/article/252330b0209f428c86ff38f1c8a27303
Autor:
Viviana Delgado-Betancourt, Kroekkiat Chinda, Pietro Mesirca, Christian Barrère, Aurélie Covinhes, Laura Gallot, Anne Vincent, Isabelle Bidaud, Sarawut Kumphune, Joël Nargeot, Christophe Piot, Kevin Wickman, Matteo Elia Mangoni, Stéphanie Barrère-Lemaire
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
BackgroundAcute myocardial infarction (AMI) is the major cause of cardiovascular mortality worldwide. Most ischemic episodes are triggered by an increase in heart rate, which induces an imbalance between myocardial oxygen delivery and consumption. De
Externí odkaz:
https://doaj.org/article/a970e246abbf4797bacbe5953a306b1b
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/36a88c2577fe4a16994245f56c9a91e0
Autor:
Daniel Turner, Chen Kang, Pietro Mesirca, Juan Hong, Matteo E. Mangoni, Alexey V. Glukhov, Rajan Sah
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
The understanding of the electrophysiological mechanisms that underlie mechanosensitivity of the sinoatrial node (SAN), the primary pacemaker of the heart, has been evolving over the past century. The heart is constantly exposed to a dynamic mechanic
Externí odkaz:
https://doaj.org/article/7ab8744d7c2b453c85ae5fe7ecfac9a0
Autor:
Michael J. Wallace, Mona El Refaey, Pietro Mesirca, Thomas J. Hund, Matteo E. Mangoni, Peter J. Mohler
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
The pacemaker cells of the cardiac sinoatrial node (SAN) are essential for normal cardiac automaticity. Dysfunction in cardiac pacemaking results in human sinoatrial node dysfunction (SND). SND more generally occurs in the elderly population and is a
Externí odkaz:
https://doaj.org/article/12565219d0e44d409486f3ab9e98b4b4
Autor:
Isabelle Bidaud, Alicia D’Souza, Gabriella Forte, Eleonora Torre, Denis Greuet, Steeve Thirard, Cali Anderson, Antony Chung You Chong, Angelo G. Torrente, Julien Roussel, Kevin Wickman, Mark R. Boyett, Matteo E. Mangoni, Pietro Mesirca
Publikováno v:
Frontiers in Physiology, Vol 11 (2021)
Background: Endurance athletes are prone to bradyarrhythmias, which in the long-term may underscore the increased incidence of pacemaker implantation reported in this population. Our previous work in rodent models has shown training-induced sinus bra
Externí odkaz:
https://doaj.org/article/2cc2c4e30f3345eab7d6fbf48727ec24
Autor:
Julien Louradour, Olivier Bortolotti, Eleonora Torre, Isabelle Bidaud, Ned Lamb, Anne Fernandez, Jean-Yves Le Guennec, Matteo E. Mangoni, Pietro Mesirca
Publikováno v:
Cells, Vol 11, Iss 7, p 1114 (2022)
Background: Sinoatrial node cells (SANC) automaticity is generated by functional association between the activity of plasmalemmal ion channels and local diastolic intracellular Ca2+ release (LCR) from ryanodine receptors. Strikingly, most isolated SA
Externí odkaz:
https://doaj.org/article/ca195c330f954913ae0c00fe4716a237
Autor:
Futoshi Toyoda, Pietro Mesirca, Stefan Dubel, Wei-Guang Ding, Joerg Striessnig, Matteo E. Mangoni, Hiroshi Matsuura
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract The spontaneous activity of sinoatrial node (SAN) pacemaker cells is generated by a functional interplay between the activity of ionic currents of the plasma membrane and intracellular Ca2+ dynamics. The molecular correlate of a dihydropyrid
Externí odkaz:
https://doaj.org/article/31da581eaaa3446c8c655c6a488ae13e