Zobrazeno 1 - 10
of 367
pro vyhledávání: '"Pietro, De Camilli"'
Publikováno v:
Contact, Vol 6 (2023)
Mutations of the bridge-like lipid transport protein VPS13A and the lipid scramblase XK result in Chorea Acanthocytosis (ChAc) and McLeod syndrome (MLS), respectively, two similar conditions involving neurodegeneration and deformed erythrocytes (acan
Externí odkaz:
https://doaj.org/article/c747214404ff40e6b04d6800be13cedf
Autor:
Xin Yi Ng, Yumei Wu, Youneng Lin, Sidra Mohamed Yaqoob, Lois E. Greene, Pietro De Camilli, Mian Cao
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-15 (2023)
Abstract Parkinson’s disease (PD) is a neurodegenerative disorder characterized by defective dopaminergic (DAergic) input to the striatum. Mutations in two genes encoding synaptically enriched clathrin-uncoating factors, synaptojanin 1 (SJ1) and au
Externí odkaz:
https://doaj.org/article/684a650ed62248aaa50b56e755f698d3
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
ATG9 is the only transmembrane protein of the core autophagy machinery known to be present at presynapses. Here, the authors show that both synaptophysin and ATG9A vesicles assemble into condensates with synapsin but remain segregated from each other
Externí odkaz:
https://doaj.org/article/d11b9636b4584ac292b3a6667aedbe80
Autor:
Daehun Park, Yumei Wu, Sang-Eun Lee, Goeun Kim, Seonyoung Jeong, Dragomir Milovanovic, Pietro De Camilli, Sunghoe Chang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Synaptic vesicle clusters were proposed to represent phase separated condensates. Here, the authors show that only two proteins, synapsin and synaptophysin, are sufficient to make vesicle clusters in fibroblasts which are similar to those found at sy
Externí odkaz:
https://doaj.org/article/6aa311dacba44c169f50903eb2d79e75
Autor:
Lorena Benedetti, Jonathan S Marvin, Hanieh Falahati, Andres Guillén-Samander, Loren L Looger, Pietro De Camilli
Publikováno v:
eLife, Vol 9 (2020)
Light-inducible dimerization protein modules enable precise temporal and spatial control of biological processes in non-invasive fashion. Among them, Magnets are small modules engineered from the Neurospora crassa photoreceptor Vivid by orthogonalizi
Externí odkaz:
https://doaj.org/article/b309da32d02f469c8c76ebb8197e3475
Autor:
Christopher J. Stefan, William S. Trimble, Sergio Grinstein, Guillaume Drin, Karin Reinisch, Pietro De Camilli, Sarah Cohen, Alex M. Valm, Jennifer Lippincott-Schwartz, Tim P. Levine, David B. Iaea, Frederick R. Maxfield, Clare E. Futter, Emily R. Eden, Delphine Judith, Alexander R. van Vliet, Patrizia Agostinis, Sharon A. Tooze, Ayumu Sugiura, Heidi M. McBride
Publikováno v:
BMC Biology, Vol 15, Iss 1, Pp 1-24 (2017)
Abstract Discoveries spanning several decades have pointed to vital membrane lipid trafficking pathways involving both vesicular and non-vesicular carriers. But the relative contributions for distinct membrane delivery pathways in cell growth and org
Externí odkaz:
https://doaj.org/article/57743286285748dc972d7417983b6f72
Axonal transport is key to neuronal function. Efficient transport requires specific motor-cargo association in the soma, yet the mechanisms regulating this early step remain poorly understood. We found that EBP-1, theC. elegansortholog of the canonic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::385da12490c352f994753f9a872dbbde
https://doi.org/10.1101/2023.01.12.523768
https://doi.org/10.1101/2023.01.12.523768
Autor:
Jinghua Ge, Xin Bian, Lu Ma, Yiying Cai, Yanghui Li, Jie Yang, Erdem Karatekin, Pietro De Camilli, Yongli Zhang
Publikováno v:
Nat Chem Biol
Extended synaptotagmins (E-Syts) mediate lipid exchange between the endoplasmic reticulum (ER) and the plasma membrane (PM). Anchored on the ER, E-Syts bind the PM via an array of C2 domains in a Ca(2+)- and lipid-dependent manner, drawing the two me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d274c330c472bb363562651254da2cc7
https://doi.org/10.1038/s41589-021-00914-3
https://doi.org/10.1038/s41589-021-00914-3
Publikováno v:
Proceedings of the National Academy of Sciences. 119
The spine apparatus is a specialized compartment of the neuronal smooth endoplasmic reticulum (ER) located in a subset of dendritic spines. It consists of stacks of ER cisterns that are interconnected by an unknown dense matrix and are continuous wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d26caa41e4eee41e80e150ccd113e1a
https://doi.org/10.1073/pnas.2203750119
https://doi.org/10.1073/pnas.2203750119
Autor:
Lu Ma, Yiying Cai, Yanghui Li, Junyi Jiao, Zhenyong Wu, Ben O'Shaughnessy, Pietro De Camilli, Erdem Karatekin, Yongli Zhang
Publikováno v:
eLife, Vol 6 (2017)
Many biological processes rely on protein–membrane interactions in the presence of mechanical forces, yet high resolution methods to quantify such interactions are lacking. Here, we describe a single-molecule force spectroscopy approach to quantify
Externí odkaz:
https://doaj.org/article/75c12d0c80d841db8a169da342f90e2d