Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Pietro, Alano"'
Autor:
Samantha Donsante, Giulia Siciliano, Mariagrazia Ciardo, Biagio Palmisano, Valeria Messina, Valeria de Turris, Giorgia Farinacci, Marta Serafini, Francesco Silvestrini, Alessandro Corsi, Mara Riminucci, Pietro Alano
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
IntroductionRecent evidence suggests that the bone marrow (BM) plays a key role in the diffusion of P. falciparum malaria by providing a “niche” for the maturation of the parasite gametocytes, responsible for human-to-mosquito transmission. Suita
Externí odkaz:
https://doaj.org/article/2ba77eac7b4846c3bed55ab736984c3a
Autor:
Giacomo Paonessa, Giulia Siciliano, Rita Graziani, Cristiana Lalli, Ottavia Cecchetti, Cristina Alli, Roberto La Valle, Alessia Petrocchi, Alessio Sferrazza, Monica Bisbocci, Mario Falchi, Carlo Toniatti, Alberto Bresciani, Pietro Alano
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)
High-throughput screening of 120,000 compounds followed by counter-screening and validation assays reveals candidate antimalarial drugs that kill Plasmodium falciparum sexual and asexual blood stages blocking parasite transmission through mosquito.
Externí odkaz:
https://doaj.org/article/59fe7c35684348d7a872e3a5b86d2bef
Autor:
Amal A. H. Gadalla, Giulia Siciliano, Ryan Farid, Pietro Alano, Lisa Ranford-Cartwright, James S. McCarthy, Joanne Thompson, Hamza A Babiker
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The use of quantitative qRT-PCR assays for detection and quantification of late gametocyte stages has revealed the high transmission capacity of the human malaria parasite, Plasmodium falciparum. To understand how the parasite adjusts its tr
Externí odkaz:
https://doaj.org/article/e868c3a6213e4d65811a67f617760857
Autor:
Marco Giacometti, Francesca Milesi, Pietro Lorenzo Coppadoro, Alberto Rizzo, Federico Fagiani, Christian Rinaldi, Matteo Cantoni, Daniela Petti, Edoardo Albisetti, Marco Sampietro, Mariagrazia Ciardo, Giulia Siciliano, Pietro Alano, Brigitte Lemen, Joel Bombe, Marie Thérèse Nwaha Toukam, Paul Fernand Tina, Maria Rita Gismondo, Mario Corbellino, Romualdo Grande, Gianfranco Beniamino Fiore, Giorgio Ferrari, Spinello Antinori, Riccardo Bertacco
Publikováno v:
Advanced Science, Vol 8, Iss 14, Pp n/a-n/a (2021)
Abstract Malaria remains the most important mosquito‐borne infectious disease worldwide, with 229 million new cases and 409.000 deaths in 2019. The infection is caused by a protozoan parasite which attacks red blood cells by feeding on hemoglobin a
Externí odkaz:
https://doaj.org/article/aa48fb84b5ab43ada70b314eb97e66c7
Autor:
Grazia Camarda, Piyaporn Jirawatcharadech, Richard S. Priestley, Ahmed Saif, Sandra March, Michael H. L. Wong, Suet Leung, Alex B. Miller, David A. Baker, Pietro Alano, Mark J. I. Paine, Sangeeta N. Bhatia, Paul M. O’Neill, Stephen A. Ward, Giancarlo A. Biagini
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Primaquine (PQ) is a widely used anti-malaria drug, but its mechanism of action is unclear. Here, Camarda et al. show that PQ’s activity against liver and sexual Plasmodium stages depends on generation of hydroxylated-PQ metabolites (OH-PQm), which
Externí odkaz:
https://doaj.org/article/53df786506df4fffaf54431621d57eba
Akademický článek
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Autor:
Noëlie Béré Henry, Samuel Sindié Sermé, Giulia Siciliano, Salif Sombié, Amidou Diarra, N’fale Sagnon, Alfred S. Traoré, Sodiomon Bienvenu Sirima, Issiaka Soulama, Pietro Alano
Publikováno v:
Malaria Journal, Vol 18, Iss 1, Pp 1-8 (2019)
Abstract While significant advances have been made in understanding Plasmodium falciparum gametocyte biology and its relationship with malaria parasite transmission, the gametocyte sex ratio contribution to this process still remains a relevant resea
Externí odkaz:
https://doaj.org/article/727c81187e99471da51d5231f3fa0f90
Autor:
Giulia Siciliano, Veronica Di Paolo, Dante Rotili, Rossella Migale, Francesca Pedini, Marialuisa Casella, Serena Camerini, Daniele Dalzoppo, Rob Henderson, Tonnie Huijs, Koen J. Dechering, Antonello Mai, Anna Maria Caccuri, Marco Lalle, Luigi Quintieri, Pietro Alano
Publikováno v:
Pharmaceuticals, Vol 15, Iss 2, p 168 (2022)
This work describes the activity of 6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)thio)hexan-1-ol (NBDHEX) and of its newly identified carboxylic acid metabolite on the human malaria parasite Plasmodium falciparum. NBDHEX has been previously identified as
Externí odkaz:
https://doaj.org/article/a949dc021e86479e8207123ad14c5b58
Autor:
Giulia Siciliano, Giulia Costa, Pablo Suárez-Cortés, Angelo Valleriani, Pietro Alano, Elena A. Levashina
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
The egress and fertilization of Plasmodium gametes and development of a motile ookinete are the first crucial steps that mediate the successful transmission of the malaria parasites from humans to the Anopheles vector. However, limited information ex
Externí odkaz:
https://doaj.org/article/d5760d93eb7144cfa4ca709f83e9c3de
Autor:
Federica Santolamazza, Pamela Avellino, Giulia Siciliano, Franck Adama Yao, Fabrizio Lombardo, Jean Bosco Ouédraogo, David Modiano, Pietro Alano, Valentina Dianora Mangano
Publikováno v:
Malaria Journal, Vol 16, Iss 1, Pp 1-11 (2017)
Abstract Background The presence of Plasmodium falciparum gametocytes in peripheral blood is essential for human to mosquito parasite transmission. The detection of submicroscopic infections with gametocytes and the estimation of the gametocyte sex r
Externí odkaz:
https://doaj.org/article/6a10068912fe464abd223bd2781968c1