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DRP1 Inhibition Rescues Mitochondrial Integrity and Excessive Apoptosis in CS-A Disease Cell Models

Autor: Pascucci B, Spadaro F, Pietraforte D, De Nuccio C, Visentin S, Giglio P, Dogliotti E, D'Errico M.

Publikováno v: International journal of molecular sciences (Online) (2021).
info:cnr-pdr/source/autori:Pascucci B, Spadaro F, Pietraforte D, De Nuccio C, Visentin S, Giglio P, Dogliotti E and D'Errico M./titolo:DRP1 Inhibition Rescues Mitochondrial Integrity and Excessive Apoptosis in CS-A Disease Cell Models/doi:/rivista:International journal of molecular sciences (Online)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume

Cockayne syndrome group A (CS-A) is a rare recessive progeroid disorder characterized by sun sensitivity and neurodevelopmental abnormalities. Cells derived from CS-A patients present as pathological hallmarks excessive oxidative stress, mitochondria

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::28d2bf8a9b4120e6665feb3b38b0e6b1
https://publications.cnr.it/doc/457349

The Anti-Diabetic Drug Metformin Rescues Aberrant Mitochondrial Activity and Restrains Oxidative Stress in a Female Mouse Model of Rett Syndrome

Autor: Zuliani I, Urbinati C, Valenti D, Quattrini MC, Medici V, Cosentino L, Pietraforte D, Di Domenico F, Perluigi M, Vacca RA, De Filippis B.

Publikováno v: Journal of clinical medicine 9 (2020): E1669. doi:10.3390/jcm9061669.
info:cnr-pdr/source/autori:Zuliani I, Urbinati C, Valenti D, Quattrini MC, Medici V, Cosentino L, Pietraforte D, Di Domenico F, Perluigi M, Vacca RA, De Filippis B./titolo:The Anti-Diabetic Drug Metformin Rescues Aberrant Mitochondrial Activity and Restrains Oxidative Stress in a Female Mouse Model of Rett Syndrome/doi:10.3390%2Fjcm9061669./rivista:Journal of clinical medicine/anno:2020/pagina_da:E1669/pagina_a:/intervallo_pagine:E1669/volume:9

Metformin is the first-line therapy for diabetes, even in children, and a promising attractive candidate for drug repurposing. Mitochondria are emerging as crucial targets of metformin action both in the periphery and in the brain. The present study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::101f934d2bd5fcb94d48c30f1cb264c1
http://www.cnr.it/prodotto/i/424486

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