Medication Adherence in Patients With Severe Asthma Prescribed Oral Corticosteroids in the U-BIOPRED Cohort

Autor: P. J. Sterk, John H. Riley, Thomas Sandström, Anna Selby, Laurie Pahus, C. Auffray, Ioannis Pandis, Julie Corfield, R. Djukanovic, K. Sun, Massimo Caruso, Jørgen Vestbo, Matthew J. Loza, Andrew J. Simpson, Dominic Burg, I.M. Adcock, S. Bates, Scott Wagers, Ana R. Sousa, J. Corfield, Ariane H. Wagener, René Lutter, Barbro Dahlén, Ratko Djukanovic, G. Praticò, I. Pandis, N. Mores, G. Hedlin, Navin Rao, I. Horváth, Alexander Mazein, B. De Meulder, Richard G. Knowles, John-Olof Thörngren, Wolfgang Seibold, P H Howarth, Victoria M. Goss, Cristina Gómez, Clare S. Murray, Paul Brinkman, Ildiko Horvath, Anthony D. Postle, M. Caruso, Martina Gahlemann, M. Puig Valls, F.K. Chung, P. Montuschi, Dominick E. Shaw, Kai Sun, Aruna T. Bansal, Fahad Alahmadi, Amphun Chaiboonchoe, Graham Roberts, Kian Fan Chung, Yike Guo, H. Ahmed, Thomas Geiser, Klaus Bønnelykke, M. Miralpeix, Simone Hashimoto, Diane Lefaudeux, S.S. Wagers, D. Erzen, B. Thornton, Florian Singer, Louise Fleming, Stephen J. Fowler, Neil Fitch, P. Bakke, Craig E. Wheelock, Nadja Hawwa Vissing, Tim Higenbottam, Jamie Matthews, F. Singer, S.E. Dahlén, Sarah Masefield, Roelinde Middelveld, Jens M. Hohlfeld, Anthony V. D'Amico, Paul Skipp, W.M.C. van Aalderen, Alan J. Knox, Sven-Erik Dahlén, Andrew Bush, A.T. Bansal, Pieter-Paul Hekking, Joost Brandsma, Stewart Bates, L.J. Fleming, Norbert Krug, N. Krug, Magnus Ericsson, J. Riley, P. Powel, Jacek Musiał, Amanda Roberts, Peter J. Sterk, Ian M. Adcock, Pascal Chanez, Cecile T.J. Holweg, F. Baribaud, Stelios Pavlidis, Veit J. Erpenbeck, Z. Weiszhart, C.E. Wheelock, Ralf Sigmund, James P.R. Schofield, Alexander Manta, Andrea Meiser, Susan J. Wilson, Jeanette Bigler, G. Roberts, M. van Geest, Hans Bisgaard, Urs Frey, Michael Boedigheimer, Per Bakke, Chris Compton, Enrica Bucchioni, Paolo Montuschi, David Myles, E.H.D. Bel, Anna James, Elena Formaggio, Anthony Rowe, Dominic E. Shaw, J. Haughney, P. Chanez, A.R. Sousa, S.J. Fowler, K. Fichtner, B. Dahlèn

Publikováno v: U-BIOPRED Study Group 2021, ' Medication adherence in patients with severe asthma prescribed oral corticosteroids in the U-BIOPRED cohort ', Chest . https://doi.org/10.1016/j.chest.2021.02.023
Alahmadi, Fahad H; Simpson, Andrew J; Gomez, Cristina; Ericsson, Magnus; Thörngren, John-Olof; Wheelock, Craig; Shaw, Dominic E; Fleming, Louise J; Roberts, Graham; Riley, John; Bates, Stewart; Sousa, Ana R; Knowles, Richard; Bansal, Aruna T; Corfield, Julie; Pandis, Ioannis; Sun, Kai; Bakke, Per S; Caruso, Massimo; Chanez, Pascal; ... (2021). Medication Adherence in Patients With Severe Asthma Prescribed Oral Corticosteroids in the U-BIOPRED Cohort. Chest, 160(1), pp. 53-64. Elsevier 10.1016/j.chest.2021.02.023
Chest
Chest, 2021, 160 (1), pp.53-64. ⟨10.1016/j.chest.2021.02.023⟩
Chest, 160(1), 53-64. American College of Chest Physicians

Background: Although estimates of suboptimal adherence to oral corticosteroids in asthma range from 30% to 50%, no ideal method for measurement exists; the impact of poor adherence in severe asthma is likely to be particularly high. Research Question

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::468463af63606145dd36257575147b02
http://www.scopus.com/inward/record.url?scp=85109134627&partnerID=8YFLogxK

Asthma similarities across ProAR (Brazil) and U-BIOPRED (Europe) adult cohorts of contrasting locations, ethnicity and socioeconomic status

Autor: Ana R. Sousa, Anna Selby, Jeanette Bigler, Hans Bisgaard, J. Cunha, I.M. Adcock, A.C.C. Coelho, Ryan Santos Costa, Pieter-Paul Hekking, Louise Fleming, Kai Sun, Amphun Chaiboonchoe, C.V.N. Santana, P. Moura-Santos, Scott Wagers, Ratko Djukanovic, G.P. Pinheiro, G. Hedlin, J.V. de Jesus, Kian Fan Chung, Jacek Musiał, Thomas Geiser, F. Baribaud, Emília Maria Medeiros de Andrade Belitardo, L. Cardoso, Klaus Bønnelykke, Anthony D. Postle, P H Howarth, Adelmir Souza-Machado, Valmar Biao-Lima, Stephen J. Fowler, Craig E. Wheelock, Alvaro A. Cruz, Mauricio Lima Barreto, Maria Ilma Araujo, Massimo Caruso, Laurie Pahus, P. J. Cooper, Florian Singer, W.M.C. van Aalderen, Paulo Augusto Moreira Camargos, Wolfgang Seibold, Ildiko Horvath, René Lutter, P.C.A. Almeida, I. Pandis, Victoria M. Goss, Aruna T. Bansal, John H. Riley, M. Puig Valls, P. Powel, Amanda Roberts, Alexander Mazein, M. Miralpeix, I. Paixao-Araujo, B. De Meulder, Michael Boedigheimer, Isaac Suzart Gomes-Filho, Chris Compton, C. Auffray, Jamie Matthews, Diane Lefaudeux, Elena Formaggio, A.A. Cruz, L.M. Mello, Anthony V. D'Amico, A. Lima-Matos, J. Fernandes, P. J. Sterk, Clare S. Murray, Enrica Bucchioni, Andrea Meiser, D. Erzen, Roelinde Middelveld, M. van Geest, Jørgen Vestbo, Alan J. Knox, Graham Roberts, Norbert Krug, Stewart Bates, G. Santos-Lima, Maggie Davis, Stelios Pavlidis, Paul Skipp, Yike Guo, Ariane H. Wagener, E.V. Ponte, Jens M. Hohlfeld, A. Souza-Machado, M.A. Lessa, I.S. Muniz, C.S. Cruz, Nadja Hawwa Vissing, Neuza Maria Alcantara-Neves, Tim Higenbottam, Navin Rao, Dominic Burg, Sarah Masefield, Z. Weiszhart, Matthew J. Loza, J. Haughney, Simone Hashimoto, Per Bakke, B. Thornton, José Miguel Chatkin, Andrew Bush, SE Dahlen, Joost Brandsma, N. Mores, G. Praticò, Kathleen C. Barnes, Carolina Souza-Machado, Rafael Stelmach, V. Bião-Lima, Martina Gahlemann, Paolo Montuschi, T.M.O. Souza, V.S. Vasquez, Camila Alexandrina Figueiredo, P. Chanez, Eduardo Vieira Ponte, Neil Fitch, Anthony Rowe, Cecile T.J. Holweg, S.J. Wilson, K. Fichtner, Alexander Manta, Lidia Lins, Dominic E. Shaw, David Myles, Julie Corfield, B. Dahlén, Thomas Sandström, Peter J. Sterk, Ian M. Adcock, Ralf Sigmund, James P.R. Schofield, Urs Frey, Laura C. Rodrigues, Leila Denise Alves Ferreira Amorim, E.H.D. Bel, Anna James, R.A. Franco, Paula Cristina Andrade Almeida, Paul Brinkman, H. Ahmed, Veit J. Erpenbeck, Richard G. Knowles

Publikováno v: Respiratory medicine, 161:105817. W.B. Saunders Ltd

Background Asthma prevalence is 339 million globally. ‘Severe asthma’ (SA) comprises subjects with uncontrolled asthma despite proper management. Objectives To compare asthma from diverse ethnicities and environments. Methods A cross-sectional an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1491bcad6f32c965a6ad0f8da265e17d
http://hdl.handle.net/10044/1/83995

Pathway discovery using transcriptomic profiles in adult-onset severe asthma

Autor: Pieter-Paul Hekking, Matt J. Loza, Stelios Pavlidis, Bertrand de Meulder, Diane Lefaudeux, Fred Baribaud, Charles Auffray, Ariane H. Wagener, Paul Brinkman, Rene Lutter, Aruna T. Bansal, Ana R. Sousa, Steve A. Bates, Yannis Pandis, Louise J. Fleming, Dominique E. Shaw, Stephen J. Fowler, Y. Guo, Andrea Meiser, Kai Sun, Julie Corfield, Peter H. Howarth, Elisabeth H. Bel, Ian M. Adcock, Kian Fan Chung, Ratko Djukanovic, Peter J. Sterk, I.M. Adcock, H. Ahmed, C. Auffray, P. Bakke, A.T. Bansal, F. Baribaud, S. Bates, E.H. Bel, J. Bigler, H. Bisgaard, M.J. Boedigheimer, K. Bønnelykke, J. Brandsma, P. Brinkman, E. Bucchioni, D. Burg, A. Bush, M. Caruso, A. Chaiboonchoe, P. Chanez, F.K. Chung, C.H. Compton, J. Corfield, A. D'Amico, S.E. Dahlen, B. De Meulder, R. Djukanovic, V.J. Erpenbeck, D. Erzen, K. Fichtner, N. Fitch, L.J. Fleming, E. Formaggio, S.J. Fowler, U. Frey, M. Gahlemann, T. Geiser, S. Hashimoto, J. Haughney, G. Hedlin, P.W. Hekking, T. Higenbottam, J.M. Hohlfeld, C. Holweg, I. Horváth, P. Howarth, A.J. James, R. Knowles, N. Krug, D. Lefaudeux, M.J. Loza, R. Lutter, A. Manta, S. Masefield, J.G. Matthews, A. Mazein, A. Meiser, R.J.M. Middelveld, M. Miralpeix, N. Mores, C.S. Murray, J. Musial, D. Myles, L. Pahus, I. Pandis, S. Pavlidis, P. Powel, G. Praticò, M Puig Valls, N. Rao, J. Riley, A. Roberts, G. Roberts, A. Rowe, T. Sandström, W. Seibold, A. Selby, D.E. Shaw, R. Sigmund, F. Singer, P.J. Skipp, A.R. Sousa, P.J. Sterk, K. Sun, B. Thornton, W.M. van Aalderen, M. van Geest, J. Vestbo, N.H. Vissing, A.H. Wagener, S.S. Wagers, Z. Weiszhart, C.E. Wheelock, S.J. Wilson

Publikováno v: Journal of allergy and clinical immunology, 141(4), 1280-1290. Mosby Inc.
U-BIOPRED Study Group 2018, ' Pathway discovery using transcriptomic profiles in adult-onset severe asthma ', Journal of Allergy and Clinical Immunology, vol. 141, no. 4, pp. 1280-1290 . https://doi.org/10.1016/j.jaci.2017.06.037
Journal of Allergy and Clinical Immunology, 141(4), 1280-1290. Mosby Inc.
Hekking, P-P W, Loza, M J, Pavlidis, S, De Meulder, B, Lefaudeux, D, Baribaud, F, Auffray, C, Wagener, A H, Brinkman, P, Lutter, R, Bansal, A T, Sousa, A R, Bates, S A, Pandis, Y, Flemming, L J, Shaw, D E, Fowler, S, Meiser, A, Sun, K, Corfield, J, Howarth, P, Bel, E H, Adcock, I M, Chung, K F, Djukanovic, R & Sterk Peter, J 2017, ' Pathway discovery using transcriptomic profiles in adult-onset severe asthma ', Journal of Allergy and Clinical Immunology, vol. 141, no. 4, pp. 1280-1290 . https://doi.org/10.1016/j.jaci.2017.06.037

Background: Adult-onset severe asthma is characterized by highly symptomatic disease despite high-intensity asthma treatments. Understanding of the underlying pathways of this heterogeneous disease is needed for the development of targeted treatments

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a1f7390120efcc86f31e253222be3f9
https://ruj.uj.edu.pl/xmlui/handle/item/125948

U-BIOPRED clinical adult asthma clusters linked to a subset of sputum -omics

Autor: Hugo H. Knobel, Koos Zwinderman, Anton Vink, Laurie Pahus, Elisabeth H. Bel, Wim van Aalderenm, Massimo Caruso, Marianne A. van de Pol, Lorraine Hewitt, David Balgoma, Jilaiha Gent, Paul Skipp, Sally Meah, Grazyna Bochenek, Martina Gahlemann, Xugang Hu, Graham Roberts, Stephen J. Fowler, Aleksandra Draper, Jon R Konradsen, Craig E. Wheelock, Philips Monk, Roelinde Middelveld, Päivi Söderman, Stelios Pavlidis, João P. Carvalho da Purfição Rocha, Caroline Smith, Alan J. Knox, Doroteya Staykova, Ildiko Horvath, Nadia Mores, Christophe von Garnier, Frans Wald, Uruj Hoda, Giuseppe Santini, Anne Petrén, Thomas Sandström, Alexander Mazein, Tamara Dekker, Ana R. Sousa, Andrea Maiser, Zsoka Weiszhart, Wolfgang Seibold, Susanna Palkonnen, Johan Kolmert, Cristina Gómez, Marco Sentoninco, Nancy Peffer, Anna James, Ingrid Delin, Montse Miralpeix, Antonios Aliprantis, Annemiek Dijkhuis, Amanda Roberts, Clare S. Murray, Lara Ravanetti, Yike Guo, Jenny Versnel, Richard Hu, Saeeda Lone-Satif, Jonathan Ward, Martine Robberechts, René Lutter, Linn Krueger, Antonio Pacino, Arnaldo D'Amico, Jans Hohlfeld, Scott Wagers, Neil Fitch, Pippa Powel, Matthew J. Loza, Karin Strandberg, Damijan Erzen, H. Ahmed, Per Bakke, Neil Gozzard, David Gibeon, Arianne Wagerner, Kerry Gove, Siân Williams, Ann Berglind, Rosalia Emma, Bob Thornton, Val Hudson, Elizabeth Yeyashingham, John Haughney, Ann-Sofie Lantz, Kjell Alving, Bart N. Lambrecht, Marek Sanak, Lilla Tamasi, Nadja Hawwa Vissing, Katja Nething, Barbro Dahlén, Jacek Musiał, Pim de Boer, Marcus O.D. Sjödin, Sarah Masefield, Marleen van Geest, Maciej Kupczyk, Peter H. Howarth, Alix Berton, Peter J. Sterk, David Myles, Peter Nilsson, Emma Ray, Ian M. Adcock, Pascal Chanez, Christos Rossios, Paolo Montuschi, Inge De Lepeleire, Armin Braun, Juliette Kamphuis, Davide Campagna, Salvatore Valente, Kees van Drunen, Urs Frey, Philipp Badorek, Ralf Sigmund, Malayka Rahman-Amin, Maria Mikus, James P.R. Schofield, Simone Hashimoto, Marton Szentkereszty, Gabriella Galffy, Lisa Marouzet, Barbara Smids, L. Larsson, Louise Fleming, Corinna Schoelch, Leanne Metcalf, Ashley Woosdcock, Anthony D. Postle, Maxim Kots, Sven-Erik Dahlén, J. M. Edwards, J.C. Smith, Gunilla Hedlin, Breda Flood, Veit J. Erpenbeck, Wen Yu, Susan J. Wilson, Jeanette Bigler, Jorge De Alba, Leon Carayannopoulos, Kristiane Wetzel, Klaus Fichtner, Paul Brinkman, Cecile T.J. Holweg, David Supple, Romanas Chaleckis, Coen Wiegman, Anthony Rowe, Hans Bisgaard, Annelie F. Behndig, Joost Brandsma, Richard G. Knowles, Jorge Beleta, Scott Kuo, Katherine M. Smith, Sandy Pink, Pieter-Paul Hekking, An Bautmans, Ben Nicholas, Kathrin Riemann, Michael Rutgers, Leanne Reynolds, Adesimbo Sogbesan, Dominic Burg, Aruna T. Bansal, Ulf Nihlen, Dyson Kerry, Ioannis Pandis, Julie Corfield, Björn Nordlund, Shama Naz, Wilhelm Zetterquist, Diane Lefaudeux, Xian Yang, Clair Barber, Kirsty E. Russell, Andrew Menzies-Gow, Dominic E. Shaw, Patrick Dennison, Elisabeth Henriksson, John G. Matthews, Tim Higgenbottam, Ratko Djukanovic, Charles Auffray, Kai Sun, Amphun Chaiboonchoe, Jonathan Thorsen, Nikos Lazarinis, Samantha Walker, John-Olof Thörngren, Frédéric Baribaud, Florian Singer, Klaus Bøonnelykke, John H. Riley, Magnus Ericsson, Sile Hu, Jørgen Vestbo, Bertrand De Meulder, Kamran Tariq, Maria Gerhardsson de Verdier, Stacey N. Reinke, Navin Rao, Trevor Garret, Norbert Krug, Michael Boedigheimer, Chris Compton, Cornelia Faulenbach, Hector Gallart, Matthias Klüglich, Caroline Mathon, Giorgio Pennazza, Kian Fan Chung, Thomas Geiser, Jörgen Östling, Courtney Coleman, Erika Kennington, Nora Adriaens, Jane Martin

Publikováno v: Journal of allergy and clinical immunology, 139(6), 1797-1807. Mosby Inc.
Lefaudeux, D, De Meulder, B, Loza, M J, Peffer, N, Rowe, A, Baribaud, F, Bansal, A T, Lutter, R, Sousa, A R, Corfield, J, Pandis, I, Bakke, P S, Caruso, M, Chanez, P, Dahlén, S-E, Fleming, L J, Fowler, S, Horvath, I, Krug, N, Montuschi, P, Sanak, M, Sandstrom, T, Shaw, D E, Singer, F, Sterk, P J, Roberts, G, Adcock, I M, Djukanovic, R, Auffray, C, Chung, K F & U-BIOPRED Study Group 2017, ' U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics ', Journal of Allergy and Clinical Immunology, vol. 139, no. 6, pp. 1797 . https://doi.org/10.1016/j.jaci.2016.08.048, https://doi.org/10.1016/j.jaci.2016.08.048

BACKGROUND: Asthma is a heterogeneous disease in which there is a differential response to asthma treatments. This heterogeneity needs to be evaluated so that a personalised management approach can be provided.OBJECTIVES: We stratified patients with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bceb05fd5f8f224a60a64676698b62ac
https://ruj.uj.edu.pl/xmlui/handle/item/138911

Unbiased clustering of severe asthma patients based on exhaled breath profiles

Autor: Pieter-Paul Hekking, Peter J. Sterk, Marco Santonico, Pascal Chanez, Ildiko Horvath, Hans Weda, Arnaldo D'Amico, Hugo H. Knobel, Nicholas J. W. Rattray, Tamara M.E. Nijsen, Massimo Caruso, Yuanyue Wang, Simone Hashimoto, Giorgio Pennazza, Ratko Djukanovic, Anton Vink, Fan Chung, Paolo Montuschi, Stephen J. Fowler, Paul Brinkman

Publikováno v: 5.2 Monitoring Airway Disease.

Rationale: Severe asthma is a heterogeneous clinical condition including various pathophysiological pathways. Metabolomics of exhaled air is associated with airways inflammation in patients with asthma and COPD. Aim: To reveal severe asthma phenotype

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3727b53a965eda98ec68eb175d9c4eb
https://doi.org/10.1183/13993003.congress-2015.pa3996