Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Pieter-Jan Volders"'
Autor:
Renee Salz, Emil E. Vorsteveld, Caspar I. van der Made, Simone Kersten, Merel Stemerdink, Tabea V. Riepe, Tsung-han Hsieh, Musa Mhlanga, Mihai G. Netea, Pieter-Jan Volders, Alexander Hoischen, Peter A.C. ’t Hoen
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110471- (2024)
Summary: We performed long-read transcriptome and proteome profiling of pathogen-stimulated peripheral blood mononuclear cells (PBMCs) from healthy donors to discover new transcript and protein isoforms expressed during immune responses to diverse pa
Externí odkaz:
https://doaj.org/article/10beff8397b24bafb6bd4dd1d30ec867
Autor:
Renee Salz, Nuno Saraiva-Agostinho, Emil Vorsteveld, Caspar I. van der Made, Simone Kersten, Merel Stemerdink, Jamie Allen, Pieter-Jan Volders, Sarah E. Hunt, Alexander Hoischen, Peter A.C. ’t Hoen
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-10 (2023)
Abstract Our incomplete knowledge of the human transcriptome impairs the detection of disease-causing variants, in particular if they affect transcripts only expressed under certain conditions. These transcripts are often lacking from reference trans
Externí odkaz:
https://doaj.org/article/d83c41876dc44e49a10f480b2d46d03a
Autor:
Louis Delhaye, Edith De Bruycker, Pieter-Jan Volders, Daria Fijalkowska, Delphine De Sutter, Sven Degroeve, Lennart Martens, Pieter Mestdagh, Sven Eyckerman
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Accumulating evidence highlights the role of long non-coding RNAs (lncRNAs) in cellular homeostasis, and their dysregulation in disease settings. Most lncRNAs function by interacting with proteins or protein complexes. While several orthogon
Externí odkaz:
https://doaj.org/article/eff721b69ea04988a617196e7afcaa55
Autor:
Sungsam Gong, Francesca Gaccioli, Justyna Dopierala, Ulla Sovio, Emma Cook, Pieter-Jan Volders, Lennart Martens, Paul D. W. Kirk, Sylvia Richardson, Gordon C. S. Smith, D. Stephen Charnock-Jones
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Placental dysfunction can have catastrophic or barely discernible effects ranging from miscarriage to apparently normal birth. Here the authors present a comprehensive analysis of the human placental transcriptome and identify circular RNAs and piRNA
Externí odkaz:
https://doaj.org/article/78ea657a313c40d78515e1e336473167
Publikováno v:
Frontiers in Bioinformatics, Vol 2 (2022)
Circular RNA (circRNA) is a class of endogenous non-coding RNA characterized by a back-splice junction (BSJ). In general, large-scale circRNA BSJ detection is performed based on RNA sequencing data, followed by the selection and validation of circRNA
Externí odkaz:
https://doaj.org/article/affa476aa90344ebb5569e9b6da29f05
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-8 (2020)
Abstract Background To understand biology and differences among various tissues or cell types, one typically searches for molecular features that display characteristic abundance patterns. Several specificity metrics have been introduced to identify
Externí odkaz:
https://doaj.org/article/cf8354fb868c40dc95be7b6ae379b441
Autor:
Jolien De Wyn, Mark W. Zimmerman, Nina Weichert-Leahey, Carolina Nunes, Belamy B. Cheung, Brian J. Abraham, Anneleen Beckers, Pieter-Jan Volders, Bieke Decaesteker, Daniel R. Carter, Alfred Thomas Look, Katleen De Preter, Wouter Van Loocke, Glenn M. Marshall, Adam D. Durbin, Frank Speleman, Kaat Durinck
Publikováno v:
Cancers, Vol 13, Iss 19, p 4783 (2021)
Roughly half of all high-risk neuroblastoma patients present with MYCN amplification. The molecular consequences of MYCN overexpression in this aggressive pediatric tumor have been studied for decades, but thus far, our understanding of the early ini
Externí odkaz:
https://doaj.org/article/915b0ee3e5534ef8abaa8c141e83471f
Autor:
Francisco Avila Cobos, Jasper Anckaert, Pieter-Jan Volders, Celine Everaert, Dries Rombaut, Jo Vandesompele, Katleen De Preter, Pieter Mestdagh
Publikováno v:
BMC Bioinformatics, Vol 18, Iss 1, Pp 1-9 (2017)
Abstract Background Reconstructing transcript models from RNA-sequencing (RNA-seq) data and establishing these as independent transcriptional units can be a challenging task. Current state-of-the-art tools for long non-coding RNA (lncRNA) annotation
Externí odkaz:
https://doaj.org/article/63965fae480e470b887bdcccb0daefa9
Autor:
Karen Verboom, Wouter Van Loocke, Pieter-Jan Volders, Bieke Decaesteker, Francisco Avila Cobos, Simon Bornschein, Charles E. de Bock, Zeynep Kalender Atak, Emmanuelle Clappier, Stein Aerts, Jan Cools, Jean Soulier, Tom Taghon, Pieter Van Vlierberghe, Jo Vandesompele, Frank Speleman, Kaat Durinck
Publikováno v:
Haematologica, Vol 103, Iss 12 (2018)
Externí odkaz:
https://doaj.org/article/20376f51afbd42e3b908c9d13fd65995
Autor:
Pieter-Jan Volders, Steve Lefever, Shalina Baute, Justine Nuytens, Katrien Vanderheyden, Björn Menten, Pieter Mestdagh, Jo Vandesompele
Publikováno v:
Non-Coding RNA, Vol 4, Iss 3, p 21 (2018)
The landscape of somatic copy-number alterations (SCNAs) affecting long non-coding RNAs (lncRNAs) in human cancers remains largely unexplored. While the majority of lncRNAs remain to be functionally characterized, several have been implicated in canc
Externí odkaz:
https://doaj.org/article/514fad100a834b76b14656bf22bcbefb