Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Pieter van Bokhoven"'
Autor:
Marlies Oosthoek, Lisa Vermunt, Arno de Wilde, Bram Bongers, Daniel Antwi-Berko, Philip Scheltens, Pieter van Bokhoven, Everard G. B. Vijverberg, Charlotte E. Teunissen
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-13 (2024)
Abstract Background Clinical trials in Alzheimer’s disease (AD) had high failure rates for several reasons, including the lack of biological endpoints. Fluid-based biomarkers may present a solution to measure biologically relevant endpoints. It is
Externí odkaz:
https://doaj.org/article/ae49560852f74a098698937680d6a2cf
Autor:
Daphne H. Schoenmakers, Prisca S. Leferink, Adeline Vanderver, Joshua L. Bonkowsky, Ingeborg Krägeloh-Mann, Geneviève Bernard, Enrico Bertini, Ali Fatemi, Brent L. Fogel, Nicole I. Wolf, Donna Skwirut, Allyson Buck, Brett Holberg, Elise F. Saunier-Vivar, Robert Rauner, Hanka Dekker, Pieter van Bokhoven, Menno D. Stellingwerff, Johannes Berkhof, Marjo S. van der Knaap
Publikováno v:
BMC Neurology, Vol 23, Iss 1, Pp 1-15 (2023)
Abstract Background The leukodystrophy “Vanishing White Matter” (VWM) is an orphan disease with neurological decline and high mortality. Currently, VWM has no approved treatments, but advances in understanding pathophysiology have led to identifi
Externí odkaz:
https://doaj.org/article/8f4af726592c4d9fb60b72f567204c44
Autor:
Pieter van Bokhoven, Arno de Wilde, Lisa Vermunt, Prisca S. Leferink, Sasja Heetveld, Jeffrey Cummings, Philip Scheltens, Everard G. B. Vijverberg
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-9 (2021)
Abstract Background Alzheimer’s disease (AD) is a devastating neurodegenerative disease leading to dementia. The field has made significant progress over the last 15 years. AD diagnosis has shifted from syndromal, based on signs and symptoms, to a
Externí odkaz:
https://doaj.org/article/75d2847abf9c4438ab9936c7a8f4ae9a
Autor:
Arno de Wilde, Lisa Vermunt, Philip Scheltens, Prisca S. Leferink, Jeffrey L. Cummings, Sasja Heetveld, Everard G. B. Vijverberg, Pieter van Bokhoven
Publikováno v:
van Bokhoven, P, de Wilde, A, Vermunt, L, Leferink, P S, Heetveld, S, Cummings, J, Scheltens, P & Vijverberg, E G B 2021, ' The Alzheimer’s disease drug development landscape ', Alzheimer's Research and Therapy, vol. 13, no. 1, 186 . https://doi.org/10.1186/s13195-021-00927-z
Alzheimer's Research and Therapy, 13(1):186. BioMed Central
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-9 (2021)
Alzheimer's Research & Therapy
Alzheimer's Research and Therapy, 13(1):186. BioMed Central
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-9 (2021)
Alzheimer's Research & Therapy
Background Alzheimer’s disease (AD) is a devastating neurodegenerative disease leading to dementia. The field has made significant progress over the last 15 years. AD diagnosis has shifted from syndromal, based on signs and symptoms, to a biomarker
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b0e5f1a3ac1fa9c68cb01fe6ee2ee5d
https://research.vumc.nl/en/publications/d2f6f24d-c692-44d8-85f4-9e953e2f8c7f
https://research.vumc.nl/en/publications/d2f6f24d-c692-44d8-85f4-9e953e2f8c7f
Autor:
Marjo S. van der Knaap, Joshua L. Bonkowsky, Adeline Vanderver, Raphael Schiffmann, Ingeborg Krägeloh-Mann, Enrico Bertini, Genevieve Bernard, Seyed Ali Fatemi, Nicole I. Wolf, Elise Saunier-Vivar, Robert Rauner, Hanka Dekker, Pieter van Bokhoven, Peter van de Ven, Prisca S. Leferink
Publikováno v:
van der Knaap, M S, Bonkowsky, J L, Vanderver, A, Schiffmann, R, Krägeloh-Mann, I, Bertini, E, Bernard, G, Fatemi, S A, Wolf, N I, Saunier-Vivar, E, Rauner, R, Dekker, H, van Bokhoven, P, van de Ven, P & Leferink, P S 2022, ' Therapy Trial Design in Vanishing White Matter An Expert Consortium Opinion ', Neurology: Genetics, vol. 8, no. 2, e657 . https://doi.org/10.1212/NXG.0000000000000657
Neurology: Genetics
article-version (Version of Record) 3
van der Knaap, M S, Bonkowsky, J L, Vanderver, A, Schiffmann, R, Krägeloh-Mann, I, Bertini, E, Bernard, G, Fatemi, S A, Wolf, N I, Saunier-Vivar, E, Rauner, R, Dekker, H, van Bokhoven, P, van de Ven, P & Leferink, P S 2022, ' Therapy Trial Design in Vanishing White Matter An Expert Consortium Opinion ', Neurology: Genetics, vol. 8, no. 2, e657, pp. 1-15 . https://doi.org/10.1212/NXG.0000000000000657
Neurology: Genetics
article-version (Version of Record) 3
van der Knaap, M S, Bonkowsky, J L, Vanderver, A, Schiffmann, R, Krägeloh-Mann, I, Bertini, E, Bernard, G, Fatemi, S A, Wolf, N I, Saunier-Vivar, E, Rauner, R, Dekker, H, van Bokhoven, P, van de Ven, P & Leferink, P S 2022, ' Therapy Trial Design in Vanishing White Matter An Expert Consortium Opinion ', Neurology: Genetics, vol. 8, no. 2, e657, pp. 1-15 . https://doi.org/10.1212/NXG.0000000000000657
Vanishing white matter (VWM) is a leukodystrophy caused by recessive variants in the genes EIF2B1-EIF2B5. It is characterized by chronic neurologic deterioration with superimposed stress-provoked episodes of rapid decline. Disease onset spans from th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f90d11b203cd1067a817ae69be7d4be8
https://doi.org/10.1212/nxg.0000000000000657
https://doi.org/10.1212/nxg.0000000000000657
Autor:
Rhiannon M. Meredith, Sabine Spijker, Mansvelder Hd, A. Jaap Timmerman, Tim S. Heistek, Danai Riga, Ioannis Kramvis, Anton N. M. Schoffelmeer, Anouk de Weger, Roel C. van der Schors, Witte J.G. Hoogendijk, Anton W. Pieneman, Johanneke E. van der Harst, Pieter van Bokhoven, Pim van Nierop, Maija Kreetta Koskinen, Yvar van Mourik, August B. Smit
Publikováno v:
Science Translational Medicine, 9(421):eaai8753. American Association for the Advancement of Science
Science Translational Medicine, 9, eaai8753-eaai8753
Riga, D, Kramvis, I, Koskinen, M K, van Bokhoven, P, van der Harst, J E, Heistek, T S, Jaap Timmerman, A, van Nierop, P, van der Schors, R C, Pieneman, A W, de Weger, A, van Mourik, Y, Schoffelmeer, A N M, Mansvelder, H D, Meredith, R M, Hoogendijk, W J G, Smit, A B & Spijker, S 2017, ' Hippocampal extracellular matrix alterations contribute to cognitive impairment associated with a chronic depressive-like state in rats ', Science Translational Medicine, vol. 9, no. 421, eaai8753 . https://doi.org/10.1126/scitranslmed.aai8753
Riga, D, Kramvis, I, Koskinen, M K, Van Bokhoven, P, Van Der Harst, J E, Heistek, T S, Timmerman, A J, Van Nierop, P, Van Der Schors, R C, Pieneman, A W, De Weger, A, Van Mourik, Y, Schoffelmeer, A N M, Mansvelder, H D, Meredith, R M, Hoogendijk, W J G, Smit, A B & Spijker, S 2017, ' Hippocampal extracellular matrix alterations contribute to cognitive impairment associated with a chronic depressive-like state in rats ', Science Translational Medicine, vol. 9, no. 421, eaai8753 . https://doi.org/10.1126/scitranslmed.aai8753
Science Translational Medicine, 9, 421, pp. eaai8753-eaai8753
Science Translational Medicine, 9, eaai8753-eaai8753
Riga, D, Kramvis, I, Koskinen, M K, van Bokhoven, P, van der Harst, J E, Heistek, T S, Jaap Timmerman, A, van Nierop, P, van der Schors, R C, Pieneman, A W, de Weger, A, van Mourik, Y, Schoffelmeer, A N M, Mansvelder, H D, Meredith, R M, Hoogendijk, W J G, Smit, A B & Spijker, S 2017, ' Hippocampal extracellular matrix alterations contribute to cognitive impairment associated with a chronic depressive-like state in rats ', Science Translational Medicine, vol. 9, no. 421, eaai8753 . https://doi.org/10.1126/scitranslmed.aai8753
Riga, D, Kramvis, I, Koskinen, M K, Van Bokhoven, P, Van Der Harst, J E, Heistek, T S, Timmerman, A J, Van Nierop, P, Van Der Schors, R C, Pieneman, A W, De Weger, A, Van Mourik, Y, Schoffelmeer, A N M, Mansvelder, H D, Meredith, R M, Hoogendijk, W J G, Smit, A B & Spijker, S 2017, ' Hippocampal extracellular matrix alterations contribute to cognitive impairment associated with a chronic depressive-like state in rats ', Science Translational Medicine, vol. 9, no. 421, eaai8753 . https://doi.org/10.1126/scitranslmed.aai8753
Science Translational Medicine, 9, 421, pp. eaai8753-eaai8753
Patients with depression often suffer from cognitive impairments that contribute to disease burden. We used social defeat-induced persistent stress (SDPS) to induce a depressive-like state in rats and then studied long-lasting memory deficits in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14485c03202c8e2a1e1b455019ca28d0
https://doi.org/10.1126/scitranslmed.aai8753
https://doi.org/10.1126/scitranslmed.aai8753