Distinct CD44 Splice Variants Differentially Affect Collateral Artery Growth

Autor: Niels van Royen, Sebastian Grundmann, Stephan H. Schirmer, Dominique P.V. de Kleijn, Sander P.J. Joosten, Steven T. Pals, Jan J. Piek, Imo E. Hoefer, Pieter T. Bot, Gerard Pasterkamp

Publikováno v: Bot, P T, Grundmann, S, van Royen, N, Joosten, S P J, Schirmer, S H, de Kleijn, D P V, Pals, S T, Pasterkamp, G, Piek, J J & Hoefer, I E 2013, ' Distinct CD44 Splice Variants Differentially Affect Collateral Artery Growth ', Current vascular pharmacology, vol. 11, no. 1, pp. 13-20 . https://doi.org/10.2174/157016113804547584
Current vascular pharmacology, 11(1), 13-20. Bentham Science Publishers B.V.

Objective: Lack of the adhesion molecule CD44 reduces collateral artery growth (arteriogenesis) in a murine hindlimb model. CD44 function is influenced by expression of 10 alternatively spliced exons (v1-v10), with unknown effects on arteriogenesis.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63ec3bdacd0a8611247e3443a1df9cb8
https://doi.org/10.2174/1570161111309010013

Hyaluronic acid: targeting immune modulatory components of the extracellular matrix in atherosclerosis

Autor: Imo E. Hoefer, Jan J. Piek, Gerard Pasterkamp, Pieter T. Bot

Publikováno v: Current medicinal chemistry. 15(8):786-791

Purpose of review: Atherosclerosis is a chronic inflammatory disease of the vessel wall. Although it has become common knowledge that hyaluronic acid (HA), an important component of the extracellular matrix, is strongly involved in atherosclerotic di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62cf9a3b34d0acf2b098cf87811adf80
https://doi.org/10.2174/092986708783955554

Forkhead box protein P1 as a downstream target of transforming growth factor-beta induces collagen synthesis and correlates with a more stable plaque phenotype

Autor: Onno J. de Boer, Niels van Royen, Jan J. Piek, Alex van Soest, Sebastian Grundmann, Pieter T. Bot, Allard C. van der Wal, Marie-José Goumans, Imo E. Hoefer, Frans L. Moll, Dominique P.V. de Kleijn, Jean-Paul P.M. de Vries, Gerard Pasterkamp

Publikováno v: Atherosclerosis, 218(1), 33-43. Elsevier Ireland Ltd
Bot, P T, Grundmann, S, Goumans, M J, de Kleijn, D, Moll, F, de Boer, O, van der Wal, A C, van Soest, A, Vries, J P, van Royen, N, Piek, J J, Pasterkamp, G & Hoefer, I E 2011, ' Forkhead box protein P1 as a downstream target of transforming growth factor-beta induces collagen synthesis and correlates with a more stable plaque phenotype ', Atherosclerosis, vol. 218, no. 1, pp. 33-43 . https://doi.org/10.1016/j.atherosclerosis.2011.05.017
Atherosclerosis, 218(1), 33-43

Objective: Atherosclerosis is an inflammatory disease, modulated by plaque stabilizing and de-stabilizing cell populations such as infiltrating monocytes and vascular smooth muscle cells (vSMCs). Transcription factors regulating proliferation and dif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::287d85754a73136df81fb8b88aef0b38
https://hdl.handle.net/1887/110646

Hyaluronic acid metabolism is increased in unstable plaques

Autor: Pieter T, Bot, Gerard, Pasterkamp, Marie-José, Goumans, Chaylendra, Strijder, Frans L, Moll, Jean-Paul, de Vries, Steven T, Pals, Dominique P, de Kleijn, Jan J, Piek, Imo E, Hoefer

Publikováno v: European journal of clinical investigation. 40(9)

Hyaluronic acid is expressed in atherosclerotic lesions, but its exact role in atherosclerotic disease remains unknown. As degradation of hyaluronic acid by hyaluronidase into low molecular weight hyaluronic acid (LMW-HA) is associated with inflammat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::efd30d7025aa00b890767d756028e3f4
https://pubmed.ncbi.nlm.nih.gov/20597964

Blocking Interferon beta Stimulates Vascular Smooth Muscle Cell Proliferation and Arteriogenesis

Autor: A. M. Van der Laan, Pieter T. Bot, Jan J. Piek, Stephan H. Schirmer, Michael Böhm, Niels van Royen, Ulrich Laufs, Imo E. Hoefer, Carlie J.M. de Vries, Anton J.G. Horrevoets, Joost O. Fledderus, Oscar L. Volger

Publikováno v: Journal of Biological Chemistry, 285(45), 34677-34685. American Society for Biochemistry and Molecular Biology Inc.
Schirmer, S H, Bot, P T, Fledderus, J O, van der Laan, A M, Volger, O L, Laufs, U, Bohm, M, de Vries, C J M, Horrevoets, A J G, Piek, J J, Hoefer, I E & van Royen, N 2010, ' Blocking Interferon beta Stimulates Vascular Smooth Muscle Cell Proliferation and Arteriogenesis ', Journal of Biological Chemistry, vol. 285, no. 45, pp. 34677-34685 . https://doi.org/10.1074/jbc.M110.164350
Journal of biological chemistry, 285(45), 34677-34685. American Society for Biochemistry and Molecular Biology Inc.

Increased interferon (IFN)-beta signaling in patients with insufficient coronary collateralization and an inhibitory effect of IFNbeta on collateral artery growth in mice have been reported. The mechanisms of IFNbeta-induced inhibition of arteriogene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc81f86b93c269422490d2310b558a3f
https://research.vumc.nl/en/publications/93e32155-be9a-4bd9-b631-7c238d7a7801