Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Pieter S, Siebenga"'
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 4, Pp 981-993 (2022)
Abstract Selective inhibition of certain voltage‐gated sodium channels (Navs), such as Nav1.8, is of primary interest for pharmacological pain research and widely studied as a pharmacological target due to its contribution to repetitive firing, neu
Externí odkaz:
https://doaj.org/article/78f4b743b5cc4db5bbdbb4ef4828e4bf
Autor:
Aletta, de Wit, Pieter S, Siebenga, Ruscha W, Wijdeveld, Petra C, Koopmans, Jani A J, van Loghem
Publikováno v:
Journal of Cosmetic Dermatology. 21:5576-5583
Skin revitalizers are used for skin quality improvement purposes. Hyaluronan hybrid cooperative complexes (HCC, Profhilo®, IBSA Pharmaceuticals) are an anti-aging treatment with a large amount of pure hyaluronic acid (HA) based on stable, cooperativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::686abb2e8418574a5120a54b27529d67
https://doi.org/10.1111/jocd.15157
https://doi.org/10.1111/jocd.15157
Autor:
Geert Jan Groeneveld, Guido van Amerongen, Pieter S. Siebenga, Richard P. Butt, Justin L. Hay, Aoibhinn McDonnell, Donal Gorman
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 2, Pp 318-324 (2020)
Clinical and Translational Science
Clinical and Translational Science
Sodium channel blockers are used for the treatment of pain, but this is limited by the lack of selectivity for different sodium channel subtypes, which can result in central nervous system and cardiovascular side effects. As such, there is special in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27398e43859e792191b0fe0cdc7418db
https://doaj.org/article/00db826e397843549f2242867246cc5a
https://doaj.org/article/00db826e397843549f2242867246cc5a
Autor:
Pieter S. Siebenga, Alexander L.H. Mentink, Geert Jan Groeneveld, Jan R. Buitenweg, Robert Doll, Boudewijn van den Berg
Publikováno v:
Behavior Research Methods
Behavior Research Methods, 52(4), 1617-1628. SPRINGER
Behavior research methods, 52(4), 1617-1628. Springer
Behavior Research Methods, 52(4), 1617-1628. SPRINGER
Behavior research methods, 52(4), 1617-1628. Springer
Measuring altered nociceptive processing involved in chronic pain is difficult due to a lack of objective methods. Potential methods to characterize human nociceptive processing involve measuring neurophysiological activity and psychophysical respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49a4e62c778ff9fd00776170e29bb71b
https://doi.org/10.3758/s13428-019-01338-7
https://doi.org/10.3758/s13428-019-01338-7
Autor:
Francis M. Dijkstra, Rob G. J. A. Zuiker, Pieter S. Siebenga, Richard A. Leigh‐Pemberton, Lei Sun, Joan D. Manthis, Marieke L. de Kam, Richard Lin, Lisa L. von Moltke, David Rezendes, Joop M. A. van Gerven
Publikováno v:
British journal of clinical pharmacology. 88(6)
ALKS 7119 is a novel compound with in vitro affinity highest for the SERT, and for μ receptor, αIn 10 cohorts (n = 10 subjects each), PK, safety and PD (NeuroCart tests, measuring neurophysiologic effects [pupillometry, pharmaco-EEG (pEEG)], visuom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54111141f30b8fbea7e0c8b0dfaf0d90
https://pubmed.ncbi.nlm.nih.gov/35014069
https://pubmed.ncbi.nlm.nih.gov/35014069
Publikováno v:
Clinical and Translational Science. WILEY
Clinical and Translational Science
Clinical and Translational Science
Selective inhibition of certain voltage-gated sodium channels (Na(v)s), such as Na(v)1.8, is of primary interest for pharmacological pain research and widely studied as a pharmacological target due to its contribution to repetitive firing, neuronal e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::768318174e03a1e0394a2ca61e39f2c8
https://hdl.handle.net/1887/3278291
https://hdl.handle.net/1887/3278291
Publikováno v:
Clinical and translational science. 15(4)
Selective inhibition of certain voltage-gated sodium channels (Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::56d3cf50086e8d3985f02b5539f39cd0
https://pubmed.ncbi.nlm.nih.gov/34958174
https://pubmed.ncbi.nlm.nih.gov/34958174
Autor:
Pieter Okkerse, Guido van Amerongen, Rachel Gurrell, Pinky Dua, Richard P. Butt, Geert Jan Groeneveld, Pieter S. Siebenga, Mark Whitlock, Donal Gorman, Justin L. Hay
Publikováno v:
British Journal of Anaesthesia. 123:e194-e203
Background This study investigated the analgesic effects of two doses (15 and 65 mg) of PF-06372865, a novel α2/α3/α5 gamma-aminobutyric acid A (GABAA) subunit selective partial positive allosteric modulator (PAM), compared with placebo and pregab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab87fb5998c3e34827328c1f096875fc
https://doi.org/10.1016/j.bja.2018.12.006
https://doi.org/10.1016/j.bja.2018.12.006
Publikováno v:
Pain Medicine: The Official Journal of the American Academy of Pain Medicine
Objective To evaluate the analgesic potential, safety, tolerability, and pharmacokinetics of VX-150, a pro-drug of a highly selective NaV1.8 inhibitor, in healthy subjects. Design This was a randomized, double-blind, placebo-controlled, crossover stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::822de127e61cbde65a5a99f48b4e4c88
https://doi.org/10.1093/pm/pnab032
https://doi.org/10.1093/pm/pnab032
Autor:
Guido van Amerongen, Katrina Gore, Pinky Dua, Peter T. Loudon, Donal Gorman, Geert Jan Groeneveld, Richard P. Butt, Justin L. Hay, Pieter S. Siebenga
Publikováno v:
British Journal of Clinical Pharmacology. 84:301-309
Aim Inhibitors of nerve growth factor (NGF) reduce pain in several chronic pain indications. NGF signals through tyrosine kinase receptors of the tropomyosin-related kinase (Trk) family and the unrelated p75 receptor. PF-06273340 is a small molecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4142431cb2a845a795c2e9f9feed198
https://doi.org/10.1111/bcp.13448
https://doi.org/10.1111/bcp.13448