Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Pieter R, Norden"'
Autor:
Teena Bhakuni, Pieter R. Norden, Naoto Ujiie, Can Tan, Sun Kyong Lee, Thomas Tedeschi, Yi-Wen Hsieh, Ying Wang, Ting Liu, Amani A. Fawzi, Tsutomu Kume
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Angiogenesis, the growth of new blood vessels from pre-existing vasculature, is essential for the development of new organ systems, but transcriptional control of angiogenesis remains incompletely understood. Here we show that FOXC1 is essen
Externí odkaz:
https://doaj.org/article/d858f4e6d9ad4401865ef98cf40124db
Autor:
Pieter R. Norden, Tsutomu Kume
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2021)
The lymphatic system is essential for lipid absorption/transport from the digestive system, maintenance of tissue fluid and protein homeostasis, and immune surveillance. Despite recent progress toward understanding the cellular and molecular mechanis
Externí odkaz:
https://doaj.org/article/423aff251d644d66abd39c2ce80576d2
Autor:
Pieter R Norden, Amélie Sabine, Ying Wang, Cansaran Saygili Demir, Ting Liu, Tatiana V Petrova, Tsutomu Kume
Publikováno v:
eLife, Vol 9 (2020)
Mutations in the transcription factor FOXC2 are predominately associated with lymphedema. Herein, we demonstrate a key role for related factor FOXC1, in addition to FOXC2, in regulating cytoskeletal activity in lymphatic valves. FOXC1 is induced by l
Externí odkaz:
https://doaj.org/article/4a9cc5e193e34c18a104854fe2d17136
Autor:
Pieter R. Norden, Tsutomu Kume
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
In addition to its roles in the maintenance of interstitial fluid homeostasis and immunosurveillance, the lymphatic system has a critical role in regulating transport of dietary lipids to the blood circulation. Recent work within the past two decades
Externí odkaz:
https://doaj.org/article/958a76a87cae4c1f89722aae9c676790
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0235116 (2020)
Here, we examine known GTPase regulators of vesicle trafficking events to assess whether they affect endothelial cell (EC) lumen and tube formation. We identify novel roles for the small GTPases Rab3A, Rab3B, Rab8A, Rab11A, Rab27A, RalA, RalB and cav
Externí odkaz:
https://doaj.org/article/052610860756455f90d2eb79691c312b
Autor:
Can Tan, Pieter R Norden, Wei Yu, Ting Liu, Naoto Ujiie, Sun Kyong Lee, Xiaocai Yan, Yaryna Dyakiv, Kazushi Aoto, Sagrario Ortega, Isabelle G De Plaen, Venkatesh Sampath, Tsutomu Kume
Publikováno v:
EMBO reports.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95734537d387c94c8f7011efa59be506
https://doi.org/10.15252/embr.202256030
https://doi.org/10.15252/embr.202256030
Autor:
Dae Joong Kim, Pieter R Norden, Jocelynda Salvador, David M Barry, Stephanie L K Bowers, Ondine Cleaver, George E Davis
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184461 (2017)
Here we examine the question of how endothelial cells (ECs) develop their apical membrane surface domain during lumen and tube formation. We demonstrate marked apical membrane targeting of activated Src kinases to this apical domain during early and
Externí odkaz:
https://doaj.org/article/f1a989f8e0584da284439abdd48c2c64
Autor:
Can Tan, Pieter R. Norden, Ting Liu, Naoto Ujiie, Xiaocai Yan, Kazushi Aoto, Sagrario Ortega, Isabelle G. De Plaen, Tsutomu Kume
Intestinal ischemia induces mucosal damage while simultaneously activating intestinal stem cells (ISCs), which subsequently regenerate the damaged intestinal epithelium. However, whether paracrine factors secreted from vascular endothelial cells (ECs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c4f0956efcc8c294be1ed4c3bb508f4
https://doi.org/10.1101/2022.03.03.482713
https://doi.org/10.1101/2022.03.03.482713
Autor:
Pieter R. Norden, Lisa Beckmann, Raymond Fang, Naoto Ujiie, Zhen Cai, Xian Zhang, Junghun Kweon, Ting Liu, Kazushi Aoto, Susan E. Quaggin, Hao F. Zhang, Tsutomu Kume
Impaired development and maintenance of the Schlemm’s Canal (SC) is associated with perturbed aqueous humor outflow regulation and glaucoma progression. Key molecular mechanisms, such as ANGPT/TIE2, PROX1, and VEGF-C/VEGFR-3 regulate SC development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fd909c68750412d135e468c04263b48
https://doi.org/10.1101/2022.02.20.481184
https://doi.org/10.1101/2022.02.20.481184
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147758 (2016)
A critical and understudied property of endothelial cells is their ability to form lumens and tube networks. Although considerable information has been obtained concerning these issues, including the role of Cdc42 and Rac1 and their effectors such as
Externí odkaz:
https://doaj.org/article/c4dfb27c6a0e4696806afecdeb899000