Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Pieter M. M. De Kesel"'
Publikováno v:
Journal of Thrombosis and Haemostasis. 19:1460-1471
Background Mild to moderate bleeding disorders are a diagnostic challenge. Many patients remain undiagnosed despite thorough and repeated laboratory testing. Thrombin generation (TG) is an overall assay measuring the functionality of the hemostatic s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8ffdb10cb5d833c566679453bc6fe7f
https://doi.org/10.1111/jth.15292
https://doi.org/10.1111/jth.15292
Autor:
Pieter M. M. De Kesel, Dana Huskens, Mark Roest, Katrien Devreese, Bas de Laat, Lisa N. van der Vorm, Lisa Florin
Publikováno v:
THROMBOSIS UPDATE
Thrombosis Update, Vol 1, Iss, Pp 100001-(2020)
Thrombosis Update, Vol 1, Iss, Pp 100001-(2020)
Introduction Increased levels of circulating von Willebrand Factor (VWF) in its active, platelet-binding conformation have been implicated in the pathogenesis of several thrombotic conditions as well as bleeding conditions characterized by severe thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8f72c3fe77a588c095f204ce43754fb
https://biblio.ugent.be/publication/8703984
https://biblio.ugent.be/publication/8703984
Publikováno v:
Analytical chemistry, 90(3), 1795-1804. American Chemical Society
The hematocrit (Hct) effect is one of the most important hurdles currently preventing more widespread implementation of quantitative dried blood spot (DBS) analysis in a routine context. Indeed, the Hct may affect both the accuracy of DBS methods as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e02a0a424dde215344c42fb924963d
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85041402014&origin=inward
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85041402014&origin=inward
Publikováno v:
TALANTA
Caffeine is the probe drug of choice to assess the phenotype of the drug metabolizing enzyme CYP1A2. Typically, molar concentration ratios of paraxanthine, caffeine's major metabolite, to its precursor are determined in plasma following administratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f7af681f4c37f16d08a7580c38b7afa
https://doi.org/10.1016/j.talanta.2015.05.084
https://doi.org/10.1016/j.talanta.2015.05.084
Publikováno v:
New Sampling Strategies in Toxicology and Therapeutic Drug Monitoring. :120-134
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ee8e9dedd0032ab6a402c18e31bba8f
https://doi.org/10.4155/fseb2013.14.322
https://doi.org/10.4155/fseb2013.14.322
Publikováno v:
CLINICAL PHARMACOKINETICS
Interindividual variability in the expression and function of drug metabolizing cytochrome P (CYP) 450 enzymes, determined by a combination of genetic, non-genetic and environmental parameters, is a major source of variable drug response. Phenotyping
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19fc987e9c783da189457566e502a637
https://doi.org/10.1007/s40262-015-0306-y
https://doi.org/10.1007/s40262-015-0306-y
Publikováno v:
Bioanalysis. 6:3011-3024
Background: Phenotyping, using caffeine as probe substrate, is a proper method to assess CYP1A2 activity. We evaluated the utility of dried blood spots (DBS) for CYP1A2 phenotyping. Results: LC–MS/MS methods were developed and validated for quantit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2693944d64f9b6c3dd743d57f7f9a781
https://doi.org/10.4155/bio.14.149
https://doi.org/10.4155/bio.14.149
Publikováno v:
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Although dried blood spot (DBS) sampling is increasingly receiving interest as a potential alternative to traditional blood sampling, the impact of hematocrit (Hct) on DBS results is limiting its final breakthrough in routine bioanalysis. To predict
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42c66e87848203ee8cde5979e6afd419
https://doi.org/10.1007/s00216-014-8114-z
https://doi.org/10.1007/s00216-014-8114-z
Publikováno v:
Bioanalysis. 6:2211-2227
Dried blood spot (DBS) sampling and DBS analysis have increasingly received attention during recent years. Furthermore, a substantial number of DBS methods has recently become available in clinical, forensic and occupational toxicology. In this revie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04f905f279a82b621ac5f24fe8d92cd1
https://doi.org/10.4155/bio.14.156
https://doi.org/10.4155/bio.14.156
Publikováno v:
CLINICAL PHARMACOKINETICS
Background and Objective: Dried blood spot (DBS) sampling has gained wide interest in bioanalysis during the last decade and has already been successfully applied in pharmacokinetic and phenotyping studies. However, all of the available phenotyping s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2ff11dfbc45926be87ffc5d8ad85778
https://doi.org/10.1007/s40262-014-0150-5
https://doi.org/10.1007/s40262-014-0150-5