Patterns of the within-host evolution of human norovirus in immunocompromised individuals and implications for treatmentResearch in context

Autor: Ray W. Izquierdo-Lara, Nele Villabruna, Dennis A. Hesselink, Claudia M.E. Schapendonk, Sol Ribó Pons, David Nieuwenhuijse, Jenny I.J. Meier, Ian Goodfellow, Virgil A.S.H. Dalm, Pieter L.A. Fraaij, Jeroen J.A. van Kampen, Marion P.G. Koopmans, Miranda de Graaf

Publikováno v: EBioMedicine, Vol 109, Iss , Pp 105391- (2024)

Summary: Background: Currently, there is no licensed treatment for chronic norovirus infections, but the use of intra-duodenally-delivered immunoglobulins is promising; nevertheless, varying results have limited their wide use. Little is known about

Externí odkaz: https://doaj.org/article/56a68a0132fe45dd9ced3cdeb5c4fdac

Risk factors for intensive care admission in children with severe acute asthma in the Netherlands: a prospective multicentre study

Autor: Shelley A. Boeschoten, Annemie L. Boehmer, Peter J. Merkus, Joost van Rosmalen, Johan C. de Jongste, Pieter L.A. Fraaij, Richard Molenkamp, Sabien G. Heisterkamp, Job B. van Woensel, Berber Kapitein, Eric G. Haarman, Roelie M. Wösten-van Asperen, Martin C. Kneyber, Joris Lemson, Stan Hartman, Dick A. van Waardenburg, Heleen E. Bunker-Wiersma, Carole N. Brouwer, Bart E. van Ewijk, Anneke M. Landstra, Mariel Verwaal, Anja A. Vaessen-Verberne, Sanne Hammer, Corinne M. Buysse, Matthijs de Hoog

Publikováno v: ERJ Open Research, Vol 6, Iss 3 (2020)

Rationale Severe acute asthma (SAA) can be fatal, but is often preventable. We previously observed in a retrospective cohort study, a three-fold increase in SAA paediatric intensive care (PICU) admissions between 2003 and 2013 in the Netherlands, wit

Externí odkaz: https://doaj.org/article/88ad081b9dca44a797d2189b27b17cff

Ferrets as a Novel Animal Model for Studying Human Respiratory Syncytial Virus Infections in Immunocompetent and Immunocompromised Hosts

Autor: Koert J. Stittelaar, Leon de Waal, Geert van Amerongen, Edwin J.B. Veldhuis Kroeze, Pieter L.A. Fraaij, Carel A. van Baalen, Jeroen J.A. van Kampen, Erhard van der Vries, Albert D.M.E. Osterhaus, Rik L. de Swart

Publikováno v: Viruses, Vol 8, Iss 6, p 168 (2016)

Human respiratory syncytial virus (HRSV) is an important cause of severe respiratory tract disease in immunocompromised patients. Animal models are indispensable for evaluating novel intervention strategies in this complex patient population. To comp

Externí odkaz: https://doaj.org/article/bbdd8d44f14247f2b911f8c90e38cb08

Profiling of humoral immune responses to norovirus in children across Europe

Autor: Nele Villabruna, Ray Izquierdo-Lara, Claudia M.E. Schapendonk, Erwin de Bruin, Felicity Chandler, Tran Thi Nhu Thao, Brenda M. Westerhuis, Janko van Beek, Louise Sigfrid, Carlo Giaquinto, Herman Goossens, Julia A. Bielicki, Malte Kohns Vasconcelos, Pieter L.A. Fraaij, Marion P.G. Koopmans, Miranda de Graaf

Publikováno v: Villabruna, Nele; Izquierdo-Lara, Ray W; Schapendonk, Claudia M E; de Bruin, Erwin; Chandler, Felicity; Thi Nhu Thao, Tran; Westerhuis, Brenda M; van Beek, Janko; Sigfrid, Louise; Giaquinto, Carlo; Goossens, Herman; Bielicki, Julia A; Kohns Vasconcelos, Malte; Fraaij, Pieter L A; Koopmans, Marion P G; de Graaf, Miranda (2022). Profiling of humoral immune responses to norovirus in children across Europe. Scientific Reports, 12(1), p. 14275. Nature Publishing Group 10.1038/s41598-022-18383-6
Scientific reports
Scientific reports, 12(1):14275. Nature Publishing Group
Scientific Reports, 12(1):14275. Nature Publishing Group

Human noroviruses are a major cause of gastroenteritis outbreaks worldwide. The majority of outbreaks and sporadic cases are caused by norovirus genotype GII.4 but 48 capsid genotypes and 60 polymerase genotypes (P-types) have been described, some of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::104bccb7444adff6e48df7bb65ef1eae
https://pure.eur.nl/en/publications/a87f2bff-edff-4607-82e7-64c2926be758

Three Patients With Disseminated Mycobacterial Infections Due to Severe Defects in Interferon Gamma Receptor Signaling: A Challenging Diagnosis

Autor: Eline A.M. Zijtregtop, Willem A. Dik, Iris H.I.M. Hollink, Annemarie M.C. van Rossum, Rik A. Brooimans, Mirthe S. Lourens, Arjan Bouman, Pieter L.A. Fraaij, Hanna IJspeert, Zijun Zhou, Tjakko J. van Ham, Clementien L. Vermont, P. Martin van Hagen, Virgil A. S. H. Dalm

IFN–gamma receptor (IFNGR) signaling via STAT1 is crucial in the defense against intracellular pathogens. Defects in this pathway enhance the susceptibility to infection by otherwise weak pathogenic mycobacteria, resulting in a primary immunodefici

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f785dd04e0fefd5cdeedb7b718796ef
https://doi.org/10.21203/rs.3.rs-682108/v1