Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Pieter J.A. de Koning"'
Publikováno v:
Critical Reviews™ in Immunology. 29:307-315
The granule-exocytosis pathway is the major mechanism for cytotoxic lymphocytes to kill tumor cells and virus-infected cells. Cytotoxic granules contain the pore-forming protein perforin and a set of structurally homologues serine proteases called gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c0822bd239a881d1c85a17c3b2d9e9a
https://doi.org/10.1615/critrevimmunol.v29.i4.20
https://doi.org/10.1615/critrevimmunol.v29.i4.20
Autor:
Pieter J.A. de Koning, Roel Broekhuizen, Razi Quadir, Niels Bovenschen, J. Alain Kummer, Christopher J. Froelich, J. Mirjam A. Damen, Monique Slijper
Publikováno v:
The Journal of Immunology. 180:8184-8191
Serine protease granzyme M (GrM) is highly expressed in the cytolytic granules of NK cells, which eliminate virus-infected cells and tumor cells. The molecular mechanisms by which GrM induces cell death, however, remain poorly understood. In this stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e4a588ef3fdf6a72539e28e077fac9b
https://doi.org/10.4049/jimmunol.180.12.8184
https://doi.org/10.4049/jimmunol.180.12.8184
Autor:
Bart Devreese, Razi Quadir, Stefanie A. H. de Poot, D. Margaret Worrall, Anne F. McGettrick, Wayne J. Higgins, Niels Bovenschen, Pieter J.A. de Koning, Roel Broekhuizen, J. Alain Kummer
Publikováno v:
PLoS ONE
PLOS ONE
PLoS ONE, Vol 6, Iss 8, p e22645 (2011)
PLOS ONE
PLoS ONE, Vol 6, Iss 8, p e22645 (2011)
Granzyme-mediated cell death is the major pathway for cytotoxic lymphocytes to kill virus-infected and tumor cells. In humans, five different granzymes (i.e. GrA, GrB, GrH, GrK, and GrM) are known that all induce cell death. Expression of intracellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67779b400050f253ee56c119d1f10698
http://europepmc.org/articles/PMC3152296
http://europepmc.org/articles/PMC3152296
Autor:
J. Alain Kummer, Jan T.M. van Gemert, Niels Bovenschen, Marcel G.J. Tilanus, Pieter J.A. de Koning, Ingeborg van der Tweel, Gerrit Jan Hordijk, Wun-Shaing W. Chang, Frank K.J. Leusink, Roel Broekhuizen, Razi Quadir
Publikováno v:
International journal of cancer. 125(7)
Tumorigenesis of head and neck squamous cell carcinomas (HNSCC) is associated with various genetic changes such as loss of heterozygosity (LOH) on human chromosome 18q21. This chromosomal region maps a gene cluster coding for a family of intracellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6961b043bfa39967dfa5d9bace83ef57
https://pubmed.ncbi.nlm.nih.gov/19569240
https://pubmed.ncbi.nlm.nih.gov/19569240
Autor:
Razi Quadir, Kiki Tesselaar, Pieter J.A. de Koning, Thomas J.H. Volman, J. Alain Kummer, Selcuk Colak, Niels Bovenschen
Publikováno v:
Molecular immunology. 47(4)
The cytotoxic serine protease granzyme M (GrM) is one of the five human granzymes, which are mainly expressed by cytotoxic T lymphocytes and/or NK cells. Upon perforin-dependent entry into a target cell, GrM cleaves specific substrates resulting in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f37bfef2547f2d90b47ecd78291850bc
https://pubmed.ncbi.nlm.nih.gov/19896187
https://pubmed.ncbi.nlm.nih.gov/19896187
Autor:
Pieter J.A. de Koning, Cornelis J.M. Lips, Niels Bovenschen, J. Alain Kummer, Roel Broekhuizen
Publikováno v:
Pancreas. 38(4)
The intracellular serine protease inhibitor 8 (SERPINB8) is expressed by squamous epithelium, monocytes, and a subset of neuroendocrine cells. Using immunohistochemistry, we now have further investigated the expression of SERPINB8 in normal neuroendo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::858a1818d89288a968ba49f13ec51abd
https://pubmed.ncbi.nlm.nih.gov/19188865
https://pubmed.ncbi.nlm.nih.gov/19188865
Autor:
Janice Griffith, Dorine Wouters, Angela M. Wolbink, Yoshihiro Fukuoka, J. Alain Kummer, S Marieke van Ham, Bellinda A. Bladergroen, Merel C. M. Strik, Pieter J.A. de Koning, Monique J. Kleijmeer, C. Erik Hack, Lawrence B. Schwartz
Publikováno v:
Molecular Immunology, 44, 3462-72
Molecular Immunology, 44, 14, pp. 3462-72
Molecular immunology, 44(14), 3462-3472. Elsevier Limited
Molecular Immunology, 44, 14, pp. 3462-72
Molecular immunology, 44(14), 3462-3472. Elsevier Limited
Contains fulltext : 52289.pdf (Publisher’s version ) (Closed access) Mast cells are widely distributed throughout the body and express effector functions in allergic reactions, inflammatory diseases, and host defense. Activation of mast cells resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac8049111d2ddbda981ccc9dbbf549ae
http://hdl.handle.net/2066/52289
http://hdl.handle.net/2066/52289
Autor:
Cezmi A. Akdis, Isil Barlan, Beate Rückert, Tunc Akkoc, Mübeccel Akdis, Pieter J.A. de Koning
Publikováno v:
Journal of Allergy and Clinical Immunology. 121:652-658.e1
BACKGROUND: A dysregulated and T(H)2-biased immune response appears to be a key pathogenetic factor in atopic diseases. Increased activation and massive infiltration of T cells in the dermis without any evidence for the expansion of their numbers in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::079e334f039bf4df0d01236b5f1c3f75
https://doi.org/10.1016/j.jaci.2007.12.1171
https://doi.org/10.1016/j.jaci.2007.12.1171