Zobrazeno 1 - 10
of 177
pro vyhledávání: '"Pieter J. M. Leenen"'
Publikováno v:
Immunity & Ageing, Vol 19, Iss 1, Pp 1-18 (2022)
Abstract Background Understanding mechanisms of pathologic neuroinflammation is essential for improving outcomes after central nervous system infections. Brain tissue-resident memory T cells (bTRM) are recruited during central nervous system infectio
Externí odkaz:
https://doaj.org/article/ae52d52203f944d3bcff3f4ccf028ed0
Autor:
Eline S. van der Valk, Daniël S. Mulder, Tessa Kouwenhoven, Nicole M. A. Nagtzaam, Elisabeth F. C. van Rossum, Willem A. Dik, Pieter J. M. Leenen
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundObesity is associated with chronic, low-grade inflammation, which is reflected in altered peripheral blood monocyte characteristics. The aim of this study was to analyze the monocyte subset composition (classical (CM), intermediate (IM) and
Externí odkaz:
https://doaj.org/article/03f31cd0d4a24f2a865d55d8b3f5bdfb
Autor:
Pim P. Edomskis, Willem A. Dik, Cloë L. Sparreboom, Nicole M. A. Nagtzaam, Adrie van Oudenaren, Daniël P. V. Lambrichts, Yves Bayon, Noah N. N. van Dongen, Anand G. Menon, Eelco J. R. de Graaf, Peter Paul L. O. Coene, Johan F. Lange, Pieter J. M. Leenen
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundTumor resection is the common approach in patients with colorectal malignancy. Profound insight into inflammatory changes that accompany the normal post-operative stress response will establish reference parameters useful for identification
Externí odkaz:
https://doaj.org/article/94f1397f83834b83a976b0a1c3fa39dc
Autor:
Wida Razawy, Celso H. Alves, Marijke Koedam, Patrick S. Asmawidjaja, Adriana M. C. Mus, Mohamed Oukka, Pieter J. M. Leenen, Jenny A. Visser, Bram C. J. van der Eerden, Erik Lubberts
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The IL-23 receptor (IL-23R) signaling pathway has pleiotropic effects on the differentiation of osteoclasts and osteoblasts, since it can inhibit or stimulate these processes via different pathways. However, the potential role of this pathwa
Externí odkaz:
https://doaj.org/article/4178bd5619304f8498fcb69ed29bb6bc
Autor:
Daan L. de Frel, Douwe E. Atsma, Hanno Pijl, Jacob C. Seidell, Pieter J. M. Leenen, Willem A. Dik, Elisabeth F. C. van Rossum
Publikováno v:
Frontiers in Nutrition, Vol 7 (2020)
Background: COVID-19 is a global challenge to healthcare. Obesity is common in patients with COVID-19 and seems to aggravate disease prognosis. In this review we explore the link between obesity, chronic disease, lifestyle factors and the immune syst
Externí odkaz:
https://doaj.org/article/62b71c0abfba4d098c77a00d6ad3a82b
Autor:
Behiye Özcan, Pieter J. M. Leenen, Patric J. D. Delhanty, Lucy Y. Baldéon-Rojas, Sebastian J. Neggers, Aart Jan van der Lely
Publikováno v:
Diabetology & Metabolic Syndrome, Vol 9, Iss 1, Pp 1-9 (2017)
Abstract Background Type 2 diabetes (T2D) is associated with reduced numbers and impaired function of circulating angiogenic cells (CAC) which contributes to the progression of atherosclerosis and microvascular disease. Previous studies suggest that
Externí odkaz:
https://doaj.org/article/4ca930cbad894b8daf33962ba2de46f8
Autor:
Joey Riepsaame, Adri van Oudenaren, Berlinda J. H. den Broeder, Wilfred F. J. van IJcken, Joris Pothof, Pieter J. M. Leenen
Publikováno v:
Frontiers in Immunology, Vol 4 (2013)
Dendritic cell (DC) maturation is a tightly regulated process that requires coordinated and timed developmental cues. Here we investigate whether microRNAs are involved in this process. We identify microRNAs in mouse GM-CSF-generated, monocyte-relate
Externí odkaz:
https://doaj.org/article/8e46eb2473b343ad8884e74c245f12a5
Autor:
Dolf Segers, Jonathan A. Lipton, Pieter J. M. Leenen, Caroline Cheng, Dennie Tempel, Gerard Pasterkamp, Frans L. Moll, Rini de Crom, Rob Krams
Publikováno v:
International Journal of Inflammation, Vol 2011 (2011)
Background. The chemokine CXCL10 is specifically upregulated during experimental development of plaque with an unstable phenotype. In this study we evaluated the functional consequences of these findings in mice and humans. Methods and Results. In Ap
Externí odkaz:
https://doaj.org/article/189ad23801294b2d8cf287926e48a89f
Autor:
Willem A. Dik, Monique T. Mulder, Nikita Martens, Roosmarijn F.H. Lemmers, Adrie J.M. Verhoeven, L. C. van Vark-van der Zee, M. van Hoek, Aloysius G Lieverse, Frank P.J. Leijten, Harm R. Haak, Eric J.G. Sijbrands, A.H. Maas, Pieter J. M. Leenen, C.M. Groot-van Ruijven
Publikováno v:
Atherosclerosis Plus, 44, 43-50. Elsevier Ireland Ltd
Atherosclerosis Plus, Vol 44, Iss, Pp 43-50 (2021)
Atherosclerosis Plus, Vol 44, Iss, Pp 43-50 (2021)
Background and aims: High-density lipoproteins (HDL) of patients with type 2 diabetes mellitus (T2DM) have impaired anti-inflammatory activities. The anti-inflammatory activity of HDL has been determined ex vivo after isolation by different methods f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::652f463303f7c95371af0dd4af6a5fe5
https://doi.org/10.1016/j.athplu.2021.08.006
https://doi.org/10.1016/j.athplu.2021.08.006
Autor:
Sandra T. van Tiel, Pieter J. M. Leenen, Jan A N Verhaar, Lizette Utomo, Niamh Fahy, Yvonne M. Bastiaansen-Jenniskens, Nicole Kops, Gerjo J.V.M. van Osch, Jan H. Waarsing
Publikováno v:
Journal of Orthopaedic Research
Journal of Orthopaedic Research, 39(10), 2270-2280. Wiley-Blackwell
Journal of Orthopaedic Research, 39(10), 2270-2280. Wiley-Blackwell
Macrophages play an important role in the development and progression of osteoarthritis (OA). The aim of this study was to identify macrophage phenotypes in synovium and monocyte subsets in peripheral blood in C57BL/6 mice by destabilizing the medial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05ecb0b45bdce5f8ef879a47f08bb045
http://www.scopus.com/inward/record.url?scp=85098140104&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85098140104&partnerID=8YFLogxK