Zobrazeno 1 - 10
of 218
pro vyhledávání: '"Pieter J de Jong"'
Autor:
David B West, Eric K Engelhard, Michael Adkisson, A J Nava, Julia V Kirov, Andreanna Cipollone, Brandon Willis, Jared Rapp, Pieter J de Jong, Kent C Lloyd
Publikováno v:
PLoS Genetics, Vol 12, Iss 2, p e1005691 (2016)
The unintended consequences of gene targeting in mouse models have not been thoroughly studied and a more systematic analysis is needed to understand the frequency and characteristics of off-target effects. Using RNA-seq, we evaluated targeted and ne
Externí odkaz:
https://doaj.org/article/6496b2606a6943efa0f0187ddd6c8ff0
Autor:
Amy Heidersbach, Chris Saxby, Karen Carver-Moore, Yu Huang, Yen-Sin Ang, Pieter J de Jong, Kathryn N Ivey, Deepak Srivastava
Publikováno v:
eLife, Vol 2 (2013)
microRNA-1 (miR-1) is an evolutionarily conserved, striated muscle-enriched miRNA. Most mammalian genomes contain two copies of miR-1, and in mice, deletion of a single locus, miR-1-2, causes incompletely penetrant lethality and subtle cardiac defect
Externí odkaz:
https://doaj.org/article/7e574b2d00aa47e2b8ec607b379d5148
Autor:
Jeffrey D Wall, Sung K Kim, Francesca Luca, Lucia Carbone, Alan R Mootnick, Pieter J de Jong, Anna Di Rienzo
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53682 (2013)
We sequenced reduced representation libraries by means of Illumina technology to generate over 1.5 Mb of orthologous sequence from a representative of each of the four extant gibbon genera (Nomascus, Hylobates, Symphalangus, and Hoolock). We used the
Externí odkaz:
https://doaj.org/article/840e8416694b434294287fbb23c478c9
Autor:
Mathias Ackermann, Maxim Koriabine, Fabienne Hartmann-Fritsch, Pieter J de Jong, Teresa D Lewis, Nelli Schetle, Thierry M Work, Julie Dagenais, George H Balazs, Jo-Ann C Leong
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46623 (2012)
The Chelonid fibropapilloma-associated herpesvirus (CFPHV; ChHV5) is believed to be the causative agent of fibropapillomatosis (FP), a neoplastic disease of marine turtles. While clinical signs and pathology of FP are well known, research on ChHV5 ha
Externí odkaz:
https://doaj.org/article/526be44d6d2448a2866b49d90236eacb
Autor:
Lucia Carbone, R Alan Harris, Gery M Vessere, Alan R Mootnick, Sean Humphray, Jane Rogers, Sung K Kim, Jeffrey D Wall, David Martin, Jerzy Jurka, Aleksandar Milosavljevic, Pieter J de Jong
Publikováno v:
PLoS Genetics, Vol 5, Iss 6, p e1000538 (2009)
Gibbon species have accumulated an unusually high number of chromosomal changes since diverging from the common hominoid ancestor 15-18 million years ago. The cause of this increased rate of chromosomal rearrangements is not known, nor is it known if
Externí odkaz:
https://doaj.org/article/43c01e1d3c34416d83d0a34a4185c0f2
Autor:
Lucia Carbone, Alan R Mootnick, Tilo Nadler, Pierre Moisson, Oliver Ryder, Christian Roos, Pieter J de Jong
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e4999 (2009)
The gibbon family belongs to the superfamily Hominoidea and includes 15 species divided into four genera. Each genus possesses a distinct karyotype with chromosome numbers varying from 38 to 52. This diversity is the result of numerous chromosomal ch
Externí odkaz:
https://doaj.org/article/e95f9e1c9bca41f78557ac83fb4a658e
Autor:
Lucia Carbone, Gery M Vessere, Boudewijn F H ten Hallers, Baoli Zhu, Kazutoyo Osoegawa, Alan Mootnick, Andrea Kofler, Johannes Wienberg, Jane Rogers, Sean Humphray, Carol Scott, R Alan Harris, Aleksandar Milosavljevic, Pieter J de Jong
Publikováno v:
PLoS Genetics, Vol 2, Iss 12, p e223 (2006)
Gibbons are part of the same superfamily (Hominoidea) as humans and great apes, but their karyotype has diverged faster from the common hominoid ancestor. At least 24 major chromosome rearrangements are required to convert the presumed ancestral kary
Externí odkaz:
https://doaj.org/article/65e92d206e034fbb977ceb1645b453d0
Autor:
James A Traherne, Roger Horton, Anne N Roberts, Marcos M Miretti, Matthew E Hurles, C Andrew Stewart, Jennifer L Ashurst, Alexey M Atrazhev, Penny Coggill, Sophie Palmer, Jeff Almeida, Sarah Sims, Laurens G Wilming, Jane Rogers, Pieter J de Jong, Mary Carrington, John F Elliott, Stephen Sawcer, John A Todd, John Trowsdale, Stephan Beck
Publikováno v:
PLoS Genetics, Vol 2, Iss 1, p e9 (2006)
The major histocompatibility complex (MHC) is recognised as one of the most important genetic regions in relation to common human disease. Advancement in identification of MHC genes that confer susceptibility to disease requires greater knowledge of
Externí odkaz:
https://doaj.org/article/796cf9a120334d6db80fb76c0b3a0310
Autor:
Wenxin Song, Anne P. Beigneux, Anne-Marie L. Winther, Kristian K. Kristensen, Anne L. Grønnemose, Ye Yang, Yiping Tu, Priscilla Munguia, Jazmin Morales, Hyesoo Jung, Pieter J. de Jong, Cris J. Jung, Kazuya Miyashita, Takao Kimura, Katsuyuki Nakajima, Masami Murakami, Gabriel Birrane, Haibo Jiang, Peter Tontonoz, Michael Ploug, Loren G. Fong, Stephen G. Young
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 5 (2022)
GPIHBP1, an endothelial cell (EC) protein, captures lipoprotein lipase (LPL) within the interstitial spaces (where it is secreted by myocytes and adipocytes) and transports it across ECs to its site of action in the capillary lumen. GPIHBP1’s 3-fin
Externí odkaz:
https://doaj.org/article/4780a6e489eb4eb2947f3a57c5c18c7c
Autor:
Patrick J. Heizer, Ye Yang, Yiping Tu, Paul H. Kim, Natalie Y. Chen, Yan Hu, Yuko Yoshinaga, Pieter J. de Jong, Laurent Vergnes, Jazmin E. Morales, Robert L. Li, Nicholas Jackson, Karen Reue, Stephen G. Young, Loren G. Fong
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 3, Pp 413-421 (2020)
Zinc metallopeptidase STE24 (ZMPSTE24) is essential for the conversion of farnesyl–prelamin A to mature lamin A, a key component of the nuclear lamina. In the absence of ZMPSTE24, farnesyl–prelamin A accumulates in the nucleus and exerts toxicity
Externí odkaz:
https://doaj.org/article/13a63de43af34811a3f699cc04d6c57d