Effects of specific multi-nutrient enriched diets on cerebral metabolism, cognition and neuropathology in AβPPswe-PS1dE9 mice.

Autor: Diane Jansen, Valerio Zerbi, Ilse A C Arnoldussen, Maximilian Wiesmann, Anne Rijpma, Xiaotian T Fang, Pieter J Dederen, Martina P C Mutsaers, Laus M Broersen, Dieter Lütjohann, Malgorzata Miller, Leo A B Joosten, Arend Heerschap, Amanda J Kiliaan

Publikováno v: PLoS ONE, Vol 8, Iss 9, p e75393 (2013)

Recent studies have focused on the use of multi-nutrient dietary interventions in search of alternatives for the treatment and prevention of Alzheimer's disease (AD). In this study we investigated to which extent long-term consumption of two specific

Externí odkaz: https://doaj.org/article/c3efca1f1dcd492ba7e536026746b104

Propionic acid and not caproic acid, attenuates nonalcoholic steatohepatitis and improves (cerebro) vascular functions in obese Ldlr(-/-) .Leiden mice

Autor: Marloes Hoogstad, Maximilian Wiesmann, Martine C. Morrison, Ilse A.C. Arnoldussen, Vivienne Verweij, Eveline Gart, Bram Geenen, Wim van Duyvenvoorde, Tamas Kozicz, Pieter J. Dederen, Robert Kleemann, Amanda J. Kiliaan, Anouk C. Tengeler

Publikováno v: The Faseb Journal, 34, 9575-9593
FASEB Journal 34 (2020) 7
The Faseb Journal, 34, 7, pp. 9575-9593
FASEB Journal, 34(7), 9575-9593

The obesity epidemic increases the interest to elucidate impact of short‐chain fatty acids on metabolism, obesity, and the brain. We investigated the effects of propionic acid (PA) and caproic acid (CA) on metabolic risk factors, liver and adipose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6450c28a41711aa1f25f02f3897798a
http://hdl.handle.net/2066/225913

Early intake of long-chain polyunsaturated fatty acids preserves brain structure and function in diet-induced obesity

Autor: Martina P. C. Mutsaers, Ilse A.C. Arnoldussen, Simone Bolijn, Arend Heerschap, Valerio Zerbi, Teake Kooistra, Amanda J. Kiliaan, Rikko H.J. Noordman, Marieke H. Schoemaker, Eric A.F. van Tol, Peter Y. Wielinga, Gabriele Gross, Maximilian Wiesmann, Robert Kleemann, Pieter J. Dederen

Publikováno v: Journal of Nutritional Biochemistry, 30, 177-88
Journal of Nutritional Biochemistry, 30, 177-188
Journal of Nutritional Biochemistry 30 (2016)
Journal of Nutritional Biochemistry, 30, pp. 177-88

Item does not contain fulltext Worldwide, the incidence of obesity is increasing at an alarming rate, and the number of children with obesity is especially worrisome. These developments raise concerns about the physical, psychosocial and cognitive co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad0e9d680fe019858a4fe0188635976a
https://doi.org/10.1016/j.jnutbio.2015.12.011

The Effect of a High-Fat Diet on Brain Plasticity, Inflammation and Cognition in Female ApoE4-Knockin and ApoE-Knockout Mice

Autor: Carola I.F. Janssen, Bram Geenen, Monique T. Mulder, Martina P. C. Mutsaers, Pieter J. Dederen, Amanda J. Kiliaan, Diane Jansen

Publikováno v: PLoS One (print), 11(5):e0155307. Public Library of Science
PLoS One, 11, 5
PLoS One, 11
PLoS ONE, Vol 11, Iss 5, p e0155307 (2016)
PLoS ONE

Contains fulltext : 167541.PDF (Publisher’s version ) (Open Access) Apolipoprotein E4 (ApoE4), one of three common isoforms of ApoE, is a major risk factor for late-onset Alzheimer disease (AD). ApoE-deficient mice, as well as mice expressing human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6556e9cd4eadd0c9b84a00f6838c33a5
https://pure.eur.nl/en/publications/e213ea7a-5e48-4dce-a7db-80c64c0210c3

DHA and cholesterol containing diets influence Alzheimer-like pathology, cognition and cerebral vasculature in APPswe/PS1dE9 mice

Autor: Arend Heerschap, Y.D. Reijmer, Laus M. Broersen, Katrien M. Brouwer, T. van Groen, Pieter J. Dederen, C.E.E.M. van der Zee, Amanda J. Kiliaan, Carlijn R. Hooijmans, Dieter Lütjohann

Publikováno v: Neurobiology of Disease, Vol 33, Iss 3, Pp 482-498 (2009)
Neurobiology of Disease, 33, 482-98
Neurobiology of Disease, 33, 3, pp. 482-98

Contains fulltext : 79884.pdf (Publisher’s version ) (Closed access) Cholesterol and docosahexenoic acid (DHA) may affect degenerative processes in Alzheimer's Disease (AD) by influencing Abeta metabolism indirectly via the vasculature. We investig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d628ec32c4a57d476bca3789a1c469
https://hdl.handle.net/2066/79884