Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Pieter Derdeyn"'
Autor:
Justine Lee, Siwei Chen, Roudabeh Vakil Monfared, Pieter Derdeyn, Kenneth Leong, Tiffany Chang, Kevin Beier, Pierre Baldi, Amal Alachkar
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107810- (2023)
Summary: Research shows that brain circuits controlling vital physiological processes are closely linked with endogenous time-keeping systems. In this study, we aimed to examine oscillatory gene expression patterns of well-characterized neuronal circ
Externí odkaz:
https://doaj.org/article/2db872cfd7c24d7c94adbdc7e116e90f
Autor:
Zhoule Zhu, Elizabeth Hubbard, Xinxia Guo, Daniel A.N. Barbosa, Abdul Malik Popal, Chengwei Cai, Hongjie Jiang, Zhe Zheng, Jingquan Lin, Wei Gao, Jianmin Zhang, Katrina Bartas, Desiree Macchia, Pieter Derdeyn, Casey H. Halpern, Helen S. Mayberg, Kevin T. Beier, Junming Zhu, Hemmings Wu
Publikováno v:
Brain Stimulation, Vol 14, Iss 5, Pp 1226-1233 (2021)
Objective: Deep brain stimulation (DBS) has been used as a treatment of last resort for treatment-resistant depression (TRD) for more than a decade. Many DBS targets have been proposed and tested clinically, but the underlying circuit mechanisms rema
Externí odkaz:
https://doaj.org/article/88dd737210d14c31b63085a96b731ba5
Autor:
Guilian Tian, May Hui, Desiree Macchia, Pieter Derdeyn, Alexandra Rogers, Elizabeth Hubbard, Chengfeng Liu, Jose J. Vasquez, Lara Taniguchi, Katrina Bartas, Sean Carroll, Kevin T. Beier
Publikováno v:
Cell Reports, Vol 39, Iss 5, Pp 110775- (2022)
Summary: Although midbrain dopamine (DA) circuits are central to motivated behaviors, our knowledge of how experience modifies these circuits to facilitate subsequent behavioral adaptations is limited. Here we demonstrate the selective role of a vent
Externí odkaz:
https://doaj.org/article/4fae2babd8674aea9e38cccf0871740e
Publikováno v:
Frontiers in Neural Circuits, Vol 15 (2022)
Decades of research have revealed the remarkable complexity of the midbrain dopamine (DA) system, which comprises cells principally located in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc). Neither homogenous nor serving a
Externí odkaz:
https://doaj.org/article/5e620fd7346b4158a1f73b63680d3f5e
Exposure to drugs of abuse causes long-lasting changes in connectivity to ventral tegmental area dopamine cells that contribute to drug-induced behavioral adaptations. However, it is not known which inputs are altered, largely due to technological li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80c4337e6cd45bbec62b4dce306a8256
https://doi.org/10.1101/2022.12.16.520804
https://doi.org/10.1101/2022.12.16.520804
Autor:
Hongjie Jiang, Xinxia Guo, Abdul Malik Popal, Hemmings Wu, Zhoule Zhu, Casey H. Halpern, Katrina Bartas, Junming Zhu, Zhe Zheng, Wei Gao, Desiree Macchia, Kevin T. Beier, Daniel A N Barbosa, Jianmin Zhang, Helen S. Mayberg, Chengwei Cai, Elizabeth Hubbard, Pieter Derdeyn, Jingquan Lin
Publikováno v:
Brain Stimulation, Vol 14, Iss 5, Pp 1226-1233 (2021)
Objective Deep brain stimulation (DBS) has been used as a treatment of last resort for treatment-resistant depression (TRD) for more than a decade. Many DBS targets have been proposed and tested clinically, but the underlying circuit mechanisms remai
Autor:
Guilian Tian, May Hui, Desiree Macchia, Pieter Derdeyn, Alexandra Rogers, Elizabeth Hubbard, Chengfeng Liu, Katrina Bartas, Sean Carroll, Kevin T. Beier
While midbrain dopamine (DA) neuronal circuits are central to motivated behaviors, much remains unknown about our knowledge of how these circuits are modified over time by experience to facilitate selective aspects of experience-dependent plasticity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cfe1fbd9b6b565a87c7469a7ce604f7
https://doi.org/10.1101/2021.11.05.467532
https://doi.org/10.1101/2021.11.05.467532
Autor:
Pieter Derdeyn, Kendyl Douglas, Daniel D. Von Hoff, Spyro Mousses, Jeff Kiefer, Chris Yoo, Abhishek Kothari, David Schneider
Publikováno v:
Journal of Clinical Oncology. 37:2598-2598
2598 Background: Synthetic lethal targets are proteins that are contextually vulnerable. Inhibitors of PARP1, for example, selectively produce a lethal phenotype in the context of cancer cells which have lost BRCA1 or BRCA2 function. As a high mutati