Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Pieter Claes"'
Modulation of sleep behavior in zebrafish larvae by pharmacological targeting of the orexin receptor
Autor:
Marie Pardon, Pieter Claes, Sarah Druwé, Murielle Martini, Aleksandra Siekierska, Christel Menet, Peter A. M. de Witte, Daniëlle Copmans
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
New pharmacological approaches that target orexin receptors (OXRs) are being developed to treat sleep disorders such as insomnia and narcolepsy, with fewer side effects than existing treatments. Orexins are neuropeptides that exert excitatory effects
Externí odkaz:
https://doaj.org/article/30dde744214246fa83c94fa1c4cdc927
Autor:
Toon Laeremans, Zara A. Sands, Pieter Claes, Ann De Blieck, Stephane De Cesco, Sarah Triest, Andreas Busch, David Felix, Abhinav Kumar, Veli-Pekka Jaakola, Christel Menet
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
The human genome encodes 850 G protein-coupled receptors (GPCRs), half of which are considered potential drug targets. GPCRs transduce extracellular stimuli into a plethora of vital physiological processes. Consequently, GPCRs are an attractive drug
Externí odkaz:
https://doaj.org/article/ea4599d8f7de44b08618672b548d1833
Autor:
Tatiana Piller, Louis Maes, Pieter Claes, Elena Semina, Davie Cappoen, Paul Cos, Peter Delputte, Freya Cools, Olivier Neyrolles, Francis Holvoet, An Matheeussen, Kevin Van Calster, Norbert De Kimpe, Sven Mangelinckx, Tamara Meiresonne, Guy Caljon, Maíra Bidart de Macedo, Eveline Torfs
Publikováno v:
European journal of medicinal chemistry
Tuberculosis (TB) still has a major impact on public health. In order to efficiently eradicate this life-threatening disease, the exploration of novel anti-TB drugs is of paramount importance. As part of our program to design new 2-azaanthraquinones
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::603f9641960e67fa478fd2d99ec314c1
https://pubmed.ncbi.nlm.nih.gov/31376569
https://pubmed.ncbi.nlm.nih.gov/31376569
Autor:
Luc Verschaeve, Cynthia Uythethofken, Pieter Claes, Davie Cappoen, Jan Jacobs, Norbert De Kimpe, Birgit Mertens, Vanessa Mathys, Kris Huygen
Publikováno v:
European journal of medicinal chemistry
Given the re-emergence of tuberculosis in Europe and beyond, the search for novel bio-active compound classes against this disease is of utmost importance. As a result of a high intrinsic tolerance of the etiological agent, Mycobacterium tuberculosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::952131883a4d933a1c4e301a6f488095
https://doi.org/10.1016/j.ejmech.2014.03.024
https://doi.org/10.1016/j.ejmech.2014.03.024
Autor:
Luc Verschaeve, Davie Cappoen, Jan Jacobs, Pieter Claes, Roel Anthonissen, Kris Huygen, Vanessa Mathys, Norbert De Kimpe
Publikováno v:
Journal of medicinal chemistry
Tuberculosis (TB) continues to be a worldwide health problem with over 1.4 million deaths each year. Despite efforts to develop more effective vaccines, more reliable diagnostics, and chemotherapeutics, tuberculosis remains a threat to global health,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08eb9cafa27988294091f5840cb9bbec
https://doi.org/10.1021/jm401735w
https://doi.org/10.1021/jm401735w
Publikováno v:
Synlett. 25:69-74
Various hexahydropyrazino[1,2-b]isoquinolines were synthesised as simplified saframycin analogues. Construction of this core proceeded through a tetrahydroisoquinoline synthesis followed by acylation/alkylation of the tetrahydroisoquinoline nitrogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::580c94ac48f8daae9fb5d5b77bd56248
https://doi.org/10.1055/s-0033-1340070
https://doi.org/10.1055/s-0033-1340070
Publikováno v:
Synlett. 24:1006-1010
Various ketopiperazines were synthesized as (cyclo)tryprostatin analogues. Construction of the skeleton started with a Pictet–Spengler reaction followed by acylation or alkylation of the piperidine nitrogen and condensation with a primary amine. 2-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0424d3c1a08b0986c83a5cafea8ddd00
https://doi.org/10.1055/s-0032-1316911
https://doi.org/10.1055/s-0032-1316911
Publikováno v:
Tetrahedron. 67:8747-8756
As part of our research on 2-aza analogues of pentalongin, the active principle of Pentas longiflora Oliv., the first synthesis of 2,3-disubstituted benzo[g]isoquinoline-1,5,10(2H)-triones via 3,4-disubstituted 6-hydroxybenzo[g]furo[4,3,2-de]isoquino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0dd210589cd2a2582b13a4a9e2d95efc
https://doi.org/10.1016/j.tet.2011.09.021
https://doi.org/10.1016/j.tet.2011.09.021
Publikováno v:
Tetrahedron. 66:7088-7096
3-Substituted pentalongin derivatives possessing an acetal function at C-1 were synthesized by cyclization of acylmethylnaphthoquinones. The latter naphthoquinones were prepared starting from 2-dioxolanylnaphthoquinone by means of both a stoichiometr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57a14ce976c3b6dcca18208a7e27e59c
https://doi.org/10.1016/j.tet.2010.07.012
https://doi.org/10.1016/j.tet.2010.07.012
Publikováno v:
ChemInform. 45
Various hexahydropyrazino[1,2-b]isoquinolines were synthesised as simplified saframycin analogues. Construction of this core proceeded through a tetrahydroisoquinoline synthesis followed by acylation/alkylation of the tetrahydroisoquinoline nitrogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3984432c1b5476b2500ebe89c95d97dd
https://doi.org/10.1002/chin.201424170
https://doi.org/10.1002/chin.201424170