Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Pieter B. van Loenen"'
Autor:
Lejla Medzikovic, Hylja Heese, Pieter B. van Loenen, Cindy P. A. A. van Roomen, Ingeborg B. Hooijkaas, Vincent M. Christoffels, Esther E. Creemers, Carlie J. M. de Vries, Vivian de Waard
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4, p 1600 (2021)
Fibrosis is a hallmark of adverse cardiac remodeling, which promotes heart failure, but it is also an essential repair mechanism to prevent cardiac rupture, signifying the importance of appropriate regulation of this process. In the remodeling heart,
Externí odkaz:
https://doaj.org/article/39513847d0d6451e869bd58e23897a43
Autor:
Kondababu Kurakula, Duco S. Koenis, Mark A. Herzik, Yanyun Liu, John W. Craft, Pieter B. van Loenen, Mariska Vos, M. Khang Tran, Henri H. Versteeg, Marie-José T.H. Goumans, Wolfram Ruf, Carlie J.M. de Vries, Mehmet Şen
Publikováno v:
Haematologica, Vol 103, Iss 6 (2018)
Tissue Factor is a cell-surface glycoprotein expressed in various cells of the vasculature and is the principal regulator of the blood coagulation cascade and hemostasis. Notably, aberrant expression of Tissue Factor is associated with cardiovascular
Externí odkaz:
https://doaj.org/article/f24af6fdbd004558a55a651fb28171cf
Autor:
Vincent M. Christoffels, Cindy P. A. A. van Roomen, Esther E. Creemers, Ingeborg B. Hooijkaas, Hylja Heese, Lejla Medzikovic, Vivian de Waard, Pieter B. van Loenen, Carlie J.M. de Vries
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1600, p 1600 (2021)
International journal of molecular sciences, 22(4):1600, 1-16. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences
Volume 22
Issue 4
International journal of molecular sciences, 22(4):1600, 1-16. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences
Volume 22
Issue 4
Fibrosis is a hallmark of adverse cardiac remodeling, which promotes heart failure, but it is also an essential repair mechanism to prevent cardiac rupture, signifying the importance of appropriate regulation of this process. In the remodeling heart,
Autor:
Vivian de Waard, Iker Otermin Rubio, Lejla Medzikovic, Mariska Vos, Anouk A.J. Hamers, Duco S. Koenis, Carlie J.M. de Vries, Claudia M. van Tiel, Pieter B. van Loenen, Thijs J. Beldman
Publikováno v:
Journal of biological chemistry, 293(39), 15070-15083. American Society for Biochemistry and Molecular Biology Inc.
Gene targeting via homologous recombination can occasionally result in incomplete disruption of the targeted gene. Here, we show that a widely used Nur77-deficient transgenic mouse model expresses a truncated protein encoding for part of the N-termin
Autor:
Yongsoo Kim, Duco S. Koenis, Eric Kalkhoven, Carlie J.M. de Vries, Michel van Weeghel, Jan Van den Bossche, Lejla Medzikovic, Ingrid Johanna Evers-van Gogh, Lodewyk F. A. Wessels, Pieter B. van Loenen, Stephan Huveneers, Wilbert Zwart, Mariska Vos, Noam Zelcer, Dave Speijer
Publikováno v:
Cell Reports, 24(8), 2127-2140.e7. Cell Press
Koenis, D S, Medzikovic, L, van Loenen, P B, van Weeghel, M, Huveneers, S, Vos, M, Evers-van Gogh, I J, Van den Bossche, J, Speijer, D, Kim, Y, Wessels, L, Zelcer, N, Zwart, W, Kalkhoven, E & de Vries, C J 2018, ' Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism ', Cell Reports, vol. 24, no. 8, pp. 2127-2140.e7 . https://doi.org/10.1016/j.celrep.2018.07.065
Cell Reports
Cell reports, 24(8), 2127-2140.e7. Cell Press
Koenis, D S, Medzikovic, L, van Loenen, P B, van Weeghel, M, Huveneers, S, Vos, M, Evers-van Gogh, I J, Van den Bossche, J, Speijer, D, Kim, Y, Wessels, L, Zelcer, N, Zwart, W, Kalkhoven, E & de Vries, C J 2018, ' Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism ', Cell Reports, vol. 24, no. 8, pp. 2127-2140.e7 . https://doi.org/10.1016/j.celrep.2018.07.065
Cell Reports
Cell reports, 24(8), 2127-2140.e7. Cell Press
Summary Activation of macrophages by inflammatory stimuli induces reprogramming of mitochondrial metabolism to support the production of pro-inflammatory cytokines and nitric oxide. Hallmarks of this metabolic rewiring are downregulation of α-ketogl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94991f49ac4d34b7f0b2c640621f0f79
https://research.vumc.nl/en/publications/7261beb6-504e-4838-9089-5aa1679f05b6
https://research.vumc.nl/en/publications/7261beb6-504e-4838-9089-5aa1679f05b6
Autor:
Erik N. T. P. Bakker, Vivian de Waard, Esther E. Creemers, Antonius Baartscheer, Cindy P. A. A. van Roomen, Duco S. Koenis, Judith de Vos, Amin Damanafshan, Pieter B. van Loenen, Carlie J.M. de Vries, Lejla Medzikovic, E. Karin Arkenbout
Publikováno v:
Cardiovascular research, 114(12), 1617-1628. Oxford University Press
Aims Cardiac remodelling and heart failure are promoted by persistent sympathetic activity. We recently reported that nuclear receptor Nur77 may protect against sympathetic agonist-induced cardiac remodelling in mice. The sympathetic co-transmitter n
Autor:
Milka Sokolović, Carlie J.M. de Vries, Claudia M. van Tiel, Noam Zelcer, Kondababu Kurakula, Pieter B. van Loenen, Duco S. Koenis, Perry D. Moerland, Daniela Sommer, Saskia Scheij
Publikováno v:
Kurakula, K, Sommer, D, Sokolovic, M, Moerland, P D, Scheij, S, van Loenen, P B, Koenis, D S, Zelcer, N, van Tiel, C M & de Vries, C J M 2015, ' LIM-only protein FHL2 is a positive regulator of liver X receptors in smooth muscle cells involved in lipid homeostasis ', Molecular and Cellular Biology, vol. 35, no. 1, pp. 52-62 . https://doi.org/10.1128/MCB.00525-14
Molecular and cellular biology, 35(1), 52-62. American Society for Microbiology
Molecular and Cellular Biology, 35(1), 52-62
Molecular and cellular biology, 35(1), 52-62. American Society for Microbiology
Molecular and Cellular Biology, 35(1), 52-62
The LIM-only protein FHL2 is expressed in smooth muscle cells (SMCs) and inhibits SMC-rich-lesion formation. To further elucidate the role of FHL2 in SMCs, we compared the transcriptomes of SMCs derived from wild-type (WT) and FHL2 knockout (KO) mice
Autor:
Marco Presta, Stefania Nicoli, Simone Buraschi, Chiara Tobia, Stefania Mitola, Patrizia Dell'Era, Paola Chiodelli, Pieter B. van Loenen, Efrem Foglia, Astrid E. Alewijnse
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology, 32(9), E104-E116. Lippincott Williams and Wilkins
Objective— Endothelial sphingosine-1-phosphate (S1P) receptor-1 (S1P 1 ) affects different vascular functions, including blood vessel maturation and permeability. Here, we characterized the role of the zS1P 1 ortholog in vascular development in zeb
Autor:
Didier Rognan, Astrid E. Alewijnse, Dennis Verzijl, Stephan L. M. Peters, Rob Leurs, Pieter B. van Loenen, Chris de Graaf
Publikováno v:
European Journal of Pharmacology, 667(1-3), 105-12. Elsevier
van Loenen, P B, de Graaf, C, Verzijl, D, Leurs, R, Rognan, D, Peters, S L M & Alewijnse, A E 2011, ' Agonist-dependent effects of mutations in the sphingosine-1-phosphate type 1 receptor ', European Journal of Pharmacology, vol. 667, no. 1-3, pp. 105-12 . https://doi.org/10.1016/j.ejphar.2011.05.071
European journal of pharmacology, 667(1-3), 105-112. Elsevier
van Loenen, P B, de Graaf, C, Verzijl, D, Leurs, R, Rognan, D, Peters, S L M & Alewijnse, A E 2011, ' Agonist-dependent effects of mutations in the sphingosine-1-phosphate type 1 receptor ', European Journal of Pharmacology, vol. 667, no. 1-3, pp. 105-12 . https://doi.org/10.1016/j.ejphar.2011.05.071
European journal of pharmacology, 667(1-3), 105-112. Elsevier
The sphingosine-1-phosphate type 1 (S1P(1)) receptor is a new target in the treatment of auto-immune diseases as evidenced by the recent approval of FTY720 (Fingolimod). The ligand-binding pocket of the S1P(1) receptor has been generally characterise
Autor:
Stephan L. M. Peters, Elfaridah P. Frazier, Martin C. Michel, Pieter B. van Loenen, Tim Schneider, Carsten Sand, Martina B. Michel-Reher
Publikováno v:
European journal of pharmacology, 654(1), 86-91. Elsevier
Nebivolol is a selective β 1 -adrenoceptor antagonist which, in addition, displays endothelium-dependent vasodilating properties in humans and other species. β 3 -Adrenoceptors have been proposed to be a molecular target of nebivolol-induced vasodi