Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Pieter B. Burger"'
Autor:
Thomas M. Kaiser, Pieter B. Burger
Publikováno v:
Molecules, Vol 24, Iss 11, p 2115 (2019)
Machine learning continues to make strident advances in the prediction of desired properties concerning drug development. Problematically, the efficacy of machine learning in these arenas is reliant upon highly accurate and abundant data. These two l
Externí odkaz:
https://doaj.org/article/2edba66ded2d427785a1b29a46a84bd7
Autor:
Megan J. Francis, Jonathan M. Turner, Pieter B. Burger, André S. Bachmann, Catherine M. Mills, Nathan G. Dolloff, Dalan J. Solomon, Patrick M. Woster, Yuri K. Peterson, Thomas Z. Benton
Publikováno v:
RSC Advances. 11:33260-33270
The ectoenzyme CD38 is highly expressed on the surface of mature immune cells, where they are a marker for cell activation, and also on the surface of multiple tumor cells such as multiple myeloma (MM). CD38-targeted monoclonal antibodies (MABs) such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc7194d9f8414174ff8e87f2adf2fbeb
https://doi.org/10.1039/d1ra06266b
https://doi.org/10.1039/d1ra06266b
Autor:
James P. Snyder, Dennis C. Liotta, Zackery W. Dentmon, Pieter B. Burger, Yuhong Du, Thomas M. Kaiser, Haian Fu, Qi Shi
Publikováno v:
Arkivoc. 2021:25-43
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b4c2912671de98a22f394363c53a332
https://doi.org/10.24820/ark.5550190.p011.304
https://doi.org/10.24820/ark.5550190.p011.304
Autor:
Perry W. Bartsch, Julien Sourimant, Thalia Le, Edgars Jecs, Nicole Pribut, Richard K. Plemper, Stephen C. Pelly, Robert Wilson, Zackery W. Dentmon, Savita Sharma, Pieter B. Burger, Jeong-Joong Yoon, Dennis C. Liotta, Thomas M. Kaiser, Soyon S. Hwang
Publikováno v:
ACS Infect Dis
A series of five benzimidazole-based compounds were identified using a machine learning algorithm as potential inhibitors of the respiratory syncytial virus (RSV) fusion protein. These compounds were synthesized, and compound 2 in particular exhibite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4cce3380433cbafe8e4064585046da3
https://doi.org/10.1021/acsinfecdis.9b00524
https://doi.org/10.1021/acsinfecdis.9b00524
Publikováno v:
Journal of Chemical Information and Modeling. 59:4266-4277
Biology encodes hereditary information in DNA and RNA, which are finely tuned to their biological functions and modes of biological production. The central role of nucleic acids in biological information flow makes them key targets of pharmaceutical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2c84c050ed639570dd4be9f110c2964
https://doi.org/10.1021/acs.jcim.9b00632
https://doi.org/10.1021/acs.jcim.9b00632
Autor:
Huan Huan Chen, Yuri K. Peterson, Matthew Dunworth, Patrick M. Woster, Joy E Kirkpatrick, Steven L. Holshouser, Tracy Murray-Stewart, Pieter B. Burger, Robert A. Casero
Publikováno v:
MedChemComm. 10:778-790
We have previously described the synthesis and evaluation of 3,5-diamino-1,2,4-triazole analogues as inhibitors of the flavin-dependent histone demethylase LSD1. These compounds are potent inhibitors of LSD1 without activity against monoamine oxidase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5077ca1f99d63743d7d6ca98438baca
https://doi.org/10.1039/c8md00610e
https://doi.org/10.1039/c8md00610e
Autor:
Jing Zhang, Katie L. Strong, Riley E. Perszyk, Chad R. Camp, Kevin K. Ogden, Timothy J. Wilding, Subhrajit Bhattacharya, Dennis C. Liotta, Miranda J. McDaniel, Stephen F. Traynelis, David S. Menaldino, Pieter B. Burger, Tue G. Banke, Matthew P. Epplin, Hiro Kusumoto, Kasper B. Hansen, James E. Huettner, Phuong Le, Thomas M. Kaiser, Gil Shaulsky
Publikováno v:
ACS Chem Neurosci
N-Methyl-d-aspartate receptors (NMDARs) are ionotropic ligand-gated glutamate receptors that mediate fast excitatory synaptic transmission in the central nervous system (CNS). Several neurological disorders may involve NMDAR hypofunction, which has d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d07e01a657441de0ec746261b2976f2
https://europepmc.org/articles/PMC7967294/
https://europepmc.org/articles/PMC7967294/
Autor:
Miranda J. McDaniel, Stephen F. Traynelis, Dennis C. Liotta, Pieter B. Burger, Kevin K. Ogden, Steven A. Kell
Publikováno v:
The Journal of General Physiology
Mutations in the pre-M1 helix of NMDA receptor subunits are associated with neurological disease. McDaniel et al. reveal that the helix influences channel gating, potentially through interactions with a network of aromatic amino acids within the subu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d477df81c021f0ef688d7891597ce72d
https://doi.org/10.1085/jgp.201912362
https://doi.org/10.1085/jgp.201912362
Autor:
Carly Bess Williams, Lonzie Hedgepeth, Joelle N. Zambrano, Pieter B. Burger, Kent Armeson, Christina J. Williams, Elizabeth G. Hill, Scott T. Eblen, Elizabeth S. Yeh, Tinslee Dilday
Publikováno v:
Oncotarget
HUNK is a protein kinase that is implicated in HER2-positive (HER2+) breast cancer progression and resistance to HER2 inhibitors. Though prior studies suggest there is therapeutic potential for targeting HUNK in HER2+ breast cancer, pharmacological a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7761c08f5d1bd8cd17a0c0696252cd6
https://doi.org/10.18632/oncotarget.26311
https://doi.org/10.18632/oncotarget.26311
Autor:
Christopher J. Butch, Pieter B. Burger, Alasdair J. Gibb, Stephen F. Traynelis, Kevin K. Ogden, Dennis C. Liotta, Miranda J. McDaniel, Steven A. Kell, Katie M. Vance
Publikováno v:
The Journal of Physiology. 596:4057-4089
NMDA receptors (NMDARs) are tetrameric complexes comprising two glycine‐binding GluN1 and two glutamate‐binding GluN2 subunits. Four GluN2 subunits encoded by different genes can produce up to 10 different di‐ and triheteromeric receptors. In a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8f3674fbb36752960d059f87361ef27
https://doi.org/10.1113/jp276093
https://doi.org/10.1113/jp276093